The effect of silicon dioxide nanoparticles on the lead hepatotoxicity
DOI:
https://doi.org/10.11603/mcch.2410-681X.2016.v0.i2.6665Keywords:
nanoparticles, silicon dioxide, lead, rats, hepatotoxicity.Abstract
Nanoparticles are known to facilitate transport of chemicals and medications through membrane barriers into cells. This results in the raising of toxic effect when two contaminants act on the body at the same time. The aim of this study was to determine how silicon dioxide (SiO2) nanoparticles affect the hepatotoxic properties of lead. Alanine and aspartate transaminases, alkaline phosphatase activities, as well as total protein, total bilirubin, creatinine and urea contents were measured in rat blood plasma. It has been shown that SiO2 nanoparticles did not significantly affect the above listed markers. Administration of lead acetate to the animals caused cytolysis of hepatocytes, as evidenced by significant increase of alanine and aspartate transaminases, alkaline phosphatase activities, along with significant decrease of total plasma protein and increase of total bilirubin levels. The increase of aminotransferases and alkaline phosphatase activities in animals that received both SiO2 nanoparticles and lead acetate was significant compared to the animals that received only lead acetate. This suggests that SiO2 nanoparticles, which are normally present in the environment and food products as contaminants, can enhance the negative hepatotoxic effects of lead.
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