Hepatoprotective effect of metadoxine on experimentally induced alcoholic hepatic injury in rats
DOI:
https://doi.org/10.11603/mcch.2410-681X.2015.v17.i4.5685Keywords:
metadoxine, alcoholic hepatitis, hepatic protector.Abstract
It was developed the model of alcoholic hepatitis by intragastric administration of 40 % ethanol at a dose of 7 ml/kg body weight in Wistar rats for 7 days. As blood biochemical markers of animals were used values of total protein, total bilirubin, total cholesterol, triglycerides, glucose, creatinine, urea and ceruloplasmin. It was shown that metadoxine (ionic salt of pyridoxine and pyroglutamic acid) in a dose of 90 mg/kg stabilized only rates of total protein, total bilirubin, triglycerides, creatinine, urea and ceruloplasmin. It was indicated that mechanisms for alcoholic hepatitis and its flow are different. It was assumed that the hepatoprotective effect of the drug is realized through antioxidant and anti-steatoticmechanisms.
References
Vonghia, L., Leggio, L., & Ferrulli, A. (2008). Acute alcohol intoxication European Journal of Internal Medicine.,19(8), 561–567.
Sukhareva, H. V.(2003). Alkoholnaia bolezn pecheny. Consilium medicum. Hastroэnterolohyia, 3 (5), 26–27.
Addolorato, G., Ancona, C., Capristo, E., & Gasbarrini, G. (2003). Metadoxine in the treatment of acute and chronic alcoholism: a review. International Journal of Immunopathology and Pharmacology, 16 (3), 207–214.
Díaz Martínez, M.C., Díaz Martínez, A., Villamil Salcedo, V., & Cruz Fuentes, C. (2002). Efficacy of metadoxine in the management of acute alcohol intoxication. Journal of International Medical Research, 30 (1), 44–51.
Nawasurit P., Ward, T. H., & Dodd, N.J.F. (2000). Ethanol-induced free radicals and hepatic DNA strand breaks are prevented in vivo by antioxidants. Carcinigenesis, 21, 93–99.
Corsetti, G., Stacchiotti, A., & Tedesco, L. (2011). Essential amino acid supplementation decreases liver damage induced by chronic ethanol consumption in rats. International Journal of Immunopathology and Pharmacology, 24 (3), 611-619.
USA. Center for Drug Evaluation and Research (CDER). Food and Drug Administration. Guidance for Industry: Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers. US. Department of Health and Human Services; 2005.
Stefanova, O. V. (2001). Doklinichni doslidzhennia likarskykh zasobiv. metod. K. Avitsena, 528.
Ravin, H. A. (1956). Rapid test for hepatolenticular degeneration. Lancet, 1, 7267–7271.
Burov, Iu. V., & Zhukov, V. N. (1984). Byolohycheskye modely khronycheskoho alkoholyzma. Toksykolohyia, 13, 57–92.
Petrov, A. N., Shevchuk, M. K., & Heorhyanova, E. K. (2015). Razrabotka эksperymentalnukh modelei alkoholnoho hepatyta razlychnoi stepeny tiazhesty. Byomed. zhurn., 16, 187–202.
Yvashkyna, V. T. (2005). Bolezny pecheny y zhelchevuvodiashchykh putei. rukovod. dlia vrachei, M., 2, 36.
Nadynskaia, M. Iu. (2001). Zabolevanyia pecheny, protekaiushchye s syndromom vnutrypechenochnoho kholestaza. Consilium medicum. 6 (4), 286–292.
Kullak-Ublick, G. A., Beuers, U., & Paumgartner, G. (2000). Hepatobiliary transport. Journal of Hepatology, 32 (1), 3–18.
Paumgartner, G. (2006). Medical treatment of cholestatic liver diseases. From pathobiology to pharmacological targets. World Journal of Gastroenterology, 12(28), 4445–4451.
Virit, O., Selek, S., & Bulut, M. (2008). High ceruloplasmin levels are associated with obsessive compulsive disorder: a case control study. Behavioral and Brain Functions, 18 (4), 52–58.
Parola, M., & Robino, G. (2001). Oxidative stress-related molecules and liver fibrosis. Journal of Hepatology, 35 (2), 297–306.
Weltman, M.D., Farrell, G.C., & Hall, P. (1998). Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis. Hepatology, 27 (1), 128–133.
Takeyama, Y., Kamimura, & Kuroiwa, A. (1996). Role of Kupfer cell-derived reactive oxygen intermediates in alcoholic liver disease in rats in vivo. Alcoholism: Clinical and Experimental Research, 20 (9), 335А–339А.
Shpilenya, L.S., Muzychenko, A.P., Gasbarrini, G., & Addolorato, G. (2002). Metadoxine in acute alcohol intoxication: a double-blind, randomized, placebo-controlled study. Alcoholism. Clinical and Experimental Research, 26 (3), 340–346.
