FEATURES OF PURINE METABOLISM DEPENDINGON THE CONSTITUTIONAL AND METABOLIC PHENOTYPE
DOI:
https://doi.org/10.11603/mcch.2410-681X.2024.i1.14397Keywords:
uric acid, hyperuricemia, obesity, purine metabolism, body mass indexAbstract
Introduction. The presented article shows changes in uric acid indicators depending on the body mass index. About 85–90 % of patients with hyperuricemia have no clinical signs. Long-term high levels of uric acid in the serum can cause many complications. In particular, an increase in the level of uric acid in the blood leads to the formation and deposition of urate crystals, which lead to an inflammatory reaction and damage to tissues, damage to many organs, such as joints, kidneys, blood vessels and the heart. The trend of spreading hyperuricemia is increasing significantly. It is pathogenetically associated with an increase in body mass index (BMI), unhealthy nutrition, in particular, rich in purines. Given that uric acid is the final metabolite of purine metabolism, there are 2 main pathophysiological mechanisms for increasing its level in the blood: reduced excretion, increased formation of uric acid, or a combination of the above two mechanisms.
The aim of the study – research the peculiarities of the exchange of uric acid level depending on gender and constitutional features.
Research Methods. 40 patients were examined, including 20 patients with BMI <24.9 (Group 1) and 20 patients with BMI >25 (Group 2). The average age of patients is (45±5) years. The control group is 20 practically healthy persons of the appropriate age.
Results and Discussion. Studies have shown that weight gain is accompanied by a high level of uric acid, which deepens insulin resistance and is the background for the development of cardiovascular diseases, diseases of the kidneys, joints, blood vessels, etc.
Conclusions. Disorders of purine metabolism play a significant role in the progression of diseases that are associated with hyperuricemia, but also indicate that they can be used as therapeutic targets. The obtained data indicate a greater tendency to hyperuricemia in men, in particular, with excessive body weight.
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