STUDY OF THE DRY EXTRACT FROM REISHI MUSHROOMS APPLICATION EFFICIENCY UNDER THE CONDITIONS OF BENIGN HYPERPLASIA OF THE PROSTATE GLAND IN RATS
DOI:
https://doi.org/10.11603/mcch.2410-681X.2023.i3.14133Keywords:
reishi mushrooms, dry extract, prostate hyperplasia, prostate protective effect, anti-inflammatory effectAbstract
Introduction. Treatment of prostate adenoma is a rather long process, therefore, those drugs that are effective and well tolerated by patients are preferred. These are the drugs of natural origin. Among domestic medicines used for the treatment of chronic prostatitis and benign prostatic hyperplasia, there are not enough drugs of natural origin. Therefore, the development of highly effective, safe and competitive prostate protectors of natural origin is an urgent task today.
The aim of the study – to determine the effect of dry extract from reishi mushrooms on the development of inflammatory processes in rats with testosterone-induced prostate hyperplasia.
Research Methods. The study was conducted on white male rats randomly divided into 7 groups. Testosterone-induced hyperplasia of the prostate gland was modeled by subcutaneously injecting animals with a fixed dose of testosterone propionate for 3 weeks. Reishi mushroom extract was administered intragastrically daily for 21 days at a dose of 100 mg/kg of animal body weight. The comparison drug "Prostatofit" was administered according to the same scheme in a 1:10 dilution at a dose of 1 ml/100 g of rat body weight. The anti-inflammatory effect of dry extract from reishi mushrooms was studied according to the following biochemical indicators: the number of leukocytes, the sedimentation rate of erythrocytes, the content of C-reactive protein, interleukin-6, tumor necrosis factor-α, testosterone and dihydrotestosterone in the blood serum of animals.
Results and Discussion. Subcutaneous administration of testosterone propionate for 21 days causes the development of inflammatory processes in the body of animals, which is confirmed by a probable increase in the number of leukocytes, ESR, the content of C-reactive protein, interleukin-6, tumor necrosis factor-α, testosterone and dihydrotestosterone in blood serum. It was proved in the experiment that the dry extract from reishi mushrooms at a dose of 100 mg/kg of the animal's body weight probably reduced the ESR, the content of leukocytes, C-reactive protein, interleukin-6, tumor necrosis factor-α, testosterone and dihydrotestosterone.
Conclusions. Dry extract from reishi mushrooms under the conditions of testosterone-induced benign prostatic hyperplasia showed a prostate protective effect due to the reduction of inflammatory processes in simulated pathology.
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