ANALYTICAL METHODS FOR THE DETERMINATION OF VALSARTAN IN MEDICINAL PRODUCTS
(LITERATURE REVIEW)
DOI:
https://doi.org/10.11603/mcch.2410-681X.2023.i1.13746Keywords:
Valsartan, high performance liquid chromatography with UV detection, absorption spectrophotometry, quantification, tablets, capsules, dosage formsAbstract
Introduction. Valsartan belongs to the group of antihypertensive drugs, an angiotensin II receptor blocker. It is used to treat hypertension, post-infarction conditions and chronic heart failure. Valsatran has been available on the pharmaceutical market for more than 25 years and, despite such a long time, has not lost its clinical efficacy compared to more modern representatives of this group of drugs. Cardiologists note the effectiveness of Valsartan in the treatment of hypertension both as monotherapy and in combination with other antihypertensive drugs.
The aim of the study – to analyze the scientific literature on the development and validation of analytical methods for the determination of valsatrite in substances and medicinal products, to summarize the information obtained, to identify the advantages and disadvantages of existing methods of analysis.
Research Methods. The information was analyzed using PubMed, PubChem, ScienceDirect, the State Pharmacopoeia of Ukraine, the European Pharmacopoeia and scientific literature.
Results and Discussion. Information on the goals, objectives, features of the study, complications arising during the development and validation of analytical methods for the determination of Valsartan in medicines is summarized. The study is of practical importance for modern pharmaceutical analysis, if the task is to develop analytical methods for the determination of valsartan in mono-formulations, the analyst can use UV-visible spectrophotometry and HPLC. If the objective is to develop analytical methods for the determination of Valsartan in binary combinations, the analyst should consider the effects of the other APIs in the combination. When the analysis shows that the other APIs do not interfere with the analysis, UV-visible spectrophotometry and HPLC should be preferred. When other APIs do interfere with the results, HPLC should be used to develop new methods for analysis.
Conclusions. The analysis of existing methods for the determination of Valsartan showed that the most commonly used methods are HPLC and UV-visible spectrophotometry. In most cases, methods for the identification and quantification of Valsartan in mono preparations and binary combinations with other APIs are described. However, these methods have a number of disadvantages: the need to use a large amount of organic solvents, as well as the length and cost of HPLC analysis; insufficient selectivity of UV and visible spectrophotometry. Peleshok K. et al. have developed simple, accurate, rapid, economical, accessible and validated spectrophotometric and chromatographic methods for the determination of Valsartan in binary combinations, substances and drugs. All methods have been developed in compliance with the principles of “green chemistry” and can be used for quality analysis in drug quality control laboratories and are recommended for inclusion in SPU monographs.
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