DISORDERS OF CONNECTIVE TISSUE METABOLISM AND THE STATE OF THE REDOX-SYSTEM IN PREGNANT WOMEN WITH UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA SYNDROME IN PREMATURE BIRTH
DOI:
https://doi.org/10.11603/mcch.2410-681X.2021.i2.12241Keywords:
undifferentiated connective tissue dysplasia, premature birth, lipid peroxidation, oxyproline, transforming growth factorAbstract
Introduction. Undifferentiated connective tissue dysplasia syndrome in pregnant women is a common cause of perinatal complications, including premature birth.
The aim of the study – to learn the dynamics of connective tissue metabolism, the state of lipid peroxidation and antioxidant system and to develop additional criteria for predicting and diagnosing pregnancy complications, premature birth in women with undifferentiated connective tissue dysplasia.
Research Methods. 38 pregnant women with UCTD in different stages of gestation (I–III trimesters) and 24 healthy pregnant women of the control group were examined. In addition to general clinical and obstetric examinations, questionnaires were conducted to identify phenotypic markers of connective tissue dysplasia, determine the activity of lipid peroxidation and antioxidant defense systems and the state of connective tissue metabolism by blood levels of transforming growth factor β1 and oxyproline.
Results and Discussion. In pregnant women the frequency of signs of UCTD was determined in 29.3 %, the frequency of premature birth was 11.1 % in the experimental group against 5.2 % in the control. At the same time in pregnant women with signs of UCTD already in the first trimester of gestation there was a significantly higher activity of oxidative processes (the level of MDA increased by 66.5 %) against the background of reduced enzymatic (11–15 %) and non-enzymatic (30 %) antioxidant protection, and catabolic processes prevailed in the connective tissue, as evidenced by the increase in daily excretion of oxyproline. In the II-III trimesters of gestation, these changes increased significantly, which became a trigger for premature birth.
Conclusions. In pregnant women with UCTD syndrome there is a pronounced progressive activation of lipid peroxidation and antioxidant system insufficient, which is a threat of perinatal complications. When critical levels are reached against the background of the predominance of catabolic processes in connective tissue becomes a trigger for premature birth.
References
Nazarenko, L.H., & Neyelova, O.V. (2015). Vahitnist i polohy za naiavnosti spoluchno-tkanynnykh dysplazii: perynatalnyi kontekst [Pregnancy and childbirth in the presence of connective tissue dysplasia: perinatal context]. Zdorovye zhenshchiny – Women's Health, 7, 83-85 [in Ukrainian].
Nechayeva, G.I., & Martynov, A.I. (2018). Klinicheskiye rekomendatsii Rossiyskogo nauchnogo meditsinskogo obshchestva terapevtov po diagnostike, lecheniyu i reabilitatsii patsiyentov s displaziyami soyedinitelnoy tkani (pervyy peresmotr) [Clinical guidelines of the Russian Scientific Medical Society of Physicians for the diagnosis, treatment and rehabilitation of patients with connective tissue dysplasia (first revision)]. Meditsinskiy vestnik Severnogo Kavkaza – Medical Bulletin of the North Caucasus, 13, 1, 2, 137-209 [in Russian].
Kerimkulova, N.V., Nikiforova, N.V., Vladimirova, I.S., Torshin, I.Y., & Gromova, O.A. (2013). Vliyaniye nedifferentsirovannoy displazii soyedinitelnoy tkani na iskhody beremennosti i rodov. Kompleksnoye obsledovaniye beremennykh s displaziyey soyedinitelnoy tkani s ispolzovaniyem metodov intellektualnogo analiza dannykh [Effects of undifferentiated connective tissue dysplasia on the outcomes of pregnancy and childbirth: a comprehensive survey of pregnant women with connecti ve ti ssue dysplasia using data mining techniques]. Zemskiy vrach – Zemsky Doctor, 2, 19, 34-38 [in Russian].
Castellino, G., Capucci, R., Bernardi, S., Padovan, M., Giacuzzo, S., Pivato, E., …, & Govoni, M. (2011). Pregnancy in patients with undifferentiated connective tissue disease: a prospective case-control study. Lupus, 20, 12, 1305-1311.
Savelyeva, I.V. (2002). Techeniye beremennosti i iskhod rodov dlya materi i ploda pri displazii soyedinitelnoy tkani [The course of pregnancy and the outcome of childbirth for the mother and fetus in connective tissue dysplasia]. Candidate᾽s thesis. Omsk [in Russian].
Kozinova, O.V. (2009). Nedifferentsrovannaya displaziya soyedinitelnoy tkani i beremennost [Undifferentiated connective tissue dysplasia and pregnancy]. Doctor᾽s thesis. Moscow [in Russian].
Smirnova, T.L., Gerasimova, L.I., Sidorov, A.E., Chernyshov, V.V., & Gubanova, E.A. (2018). Osobennosti techeniya beremennosti i rodov u zhenshchin s sindromom nedifferentsirovannoy displazii soyedinitelnoy tkani [Features of the course of pregnancy and childbirth in women with syndrome of undifferentiated connective tissue dysplasia]. Prakticheskaya meditsina – Practical medicine, 16, 6, 39-44 [in Russian].
Gurbanova, S.R. (2010). Kliniko-patogeneticheskiye obosnovaniya akusherskoy taktiki vedeniya beremennykh s istmiko-tservikalnoy nedostatochnostyu i nedifferentsirovannoy displaziyey soyedinitelnoy tkani [Clinical and pathogenetic substantiation of obstetric tactics of management of pregnant women with isthmic-cervical insufficiency and undifferentiated connective tissue dysplasia]. Candidate᾽s thesis. Moscow [in Russian].
Senkevich, О.А., Komarova, Z.A., Kowalski, J.G., Golubkina, N.A, & Puchkova, J.L. (2011). Soderzhaniye v platsente medi, tsinka, selena kak prediktor neblagopriyatnogo iskhoda beremennosti [Content of copper, zinc, selenium in placenta as a predictor of unfavorable pregnancy outcome]. Dalnevostochnyy meditsinskiy zhurnal – Far Eastern Medical Journal, 1, 47-50 [in Russian].
Pareishvili, V.V., Vakhromeev, A.P., Sitnikova, O.G., Kuzmenko, G.N., Popova, I.G., Saryeva, O.P., & Nazarov, S.B. (2018). Issledovaniye soderzhaniya N-terminalnogo propeptida prokollagena III tipa dlya diagnostiki nedifferentsirovannoy displazii soyedinitelnoy tkani u beremennykh zhenshchin [A study of the content of the n-terminal propeptide of procollagen type III for the diagnosis of undifferentiated connective tissue dysplasia in pregnant women]. Tavricheskiy mediko-biologicheskiy vestnik – Tavrida Medical and Biological Bulletin, 21, 1, 110-115 [in Russian].
Kharchenko, D.K., Tyutyunnik, N.V., Astashkin, Ye.I., Orekhova, Ns., & Novikova, A.N. (2017). Spontannoye obrazovaniye radikalov kisloroda v probakh tselnoy krovi pri preeklampsii [Spontaneous formation of oxygen radicals in whole blood samples with preeclampsia]. Proceedings of the Conference X Yubileynogo regionalnogo nauchno-obrazovatelnogo foruma “Mat i ditya” – X Anniversary Regional Scientific and Educational Forum "Mother and Child". (pp. 118-120). Moscow [in Russian].
Pristrom, A.M., & Benkhamed, M. (2012). Oksidativnyy stress i serdechno-sosudistyye zabolevaniya [Oxidative stress and cardiovascular diseases]. Lechebnoye delo – J. General Medicine, 1, 21-28 [in Russian].
Zabłocka, A., & Janusz, M. (2008). The two faces of reactive oxygen species. Postery Hig. Med. Dosw., 62, 118-124.
Shekhtman, M.M. (2008). Rukovodstvo po ekstragenitalnoy patologii u beremennykh [Guide to extragenital pathology in pregnant women]. Moscow: Triada-KH [in Russian].
Fomina, L.N. (2001). Klinicheskiye formy soyedinitelnotkannoy displazii u detey: uchebnoye posobiye [Clinical forms of connective tissue dysplasia in children: textbook]. PetrSI, Petrozavodsk [in Russian].
Korobeynikova, E.N. (1989). Modifikatsiya opredeleniya produktov perekisnogo okisleniya lipidov v reaktsii s tiobarbiturovoy kislotoy [Modification of the determination of lipid peroxidation products in the reaction with thiobarbituric acid]. Laborat. delo. – Lab. Work., 7, 8-10 [in Russian].
Honskyi, Ya.I. (Ed.). (2001). Biolohichna khimiia: laboratornyi praktykum [Biological chemistry: laboratory workshop]. Ternopil: Ukrmedknyha [in Ukrainian].
Sharaev, P.N., Ivanov, V.G., & Gavrilov, A.L. (2003). Metody laboratornogo issledovaniya pokazateley obmena kollagena v biologicheskikh zhidkostyakh: Informatsionnoye pismo dlya vrachey klinicheskoy laboratornoy diagnostiki [Methods of laboratory research of indicators of collagen metabolism in biological fluids: Information letter for doctors of clinical laboratory diagnostics]. Izhevsk [in Russian].
Kostyuk, A.L. (2018). Vahitnist i polohy u zhinok z NDST: diahnostyka i profilaktyka hestatsiynykh uskladnen. Zdorovye zhenshchyny – Women's Health, 5 (131), 53-57 [in Russian].
Sitnikova, O.G., Parejshvili, V.V., Nazarov, S.B., Vahromeev, A.P., Kusmenko, G.N., & Popova, I.G. (2015). Svobodnoradikalnoye okisleniye lipidov i antioksidantnaya aktivnost u beremennykh s nedifferentsirovannoy displaziyey soyedinitelnoy tkani pri nedonoshennoy beremennosti [Free radical oxidation of lipids and antioxidant activity in pregnant women with undifferentiated connective tissue dysplasia in premature pregnancy]. Tavricheskiy mediko-biologicheskiy vestnik – Tavrida Medical and Biological Bulletin, 1 (69), 120-122 [in Russian].
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Medical and Clinical Chemistry
This work is licensed under a Creative Commons Attribution 4.0 International License.
