CORRECTION BY B VITAMINS OF METABOLIC DISORDERS OF SULFUR-CONTAINING AMINO ACIDS IN HYPER- AND HYPOFUNCTION OF THE THYROID GLAND
DOI:
https://doi.org/10.11603/mcch.2410-681X.2019.v.i4.10850Keywords:
hyperthyroidism, hypothyroidism, cysteine, homocysteine, hydrogen sulfide, vitamins B6, B9, B12, betaineAbstract
Introduction. Hyperhomocysteinemia is a known risk factor for diseases of the cardiovascular system and a key factor in enhancing inflammation of autoimmune diseases. It is known that Hashimoto's disease is the main cause of hypothyroidism, which in itself is associated with a high level of homocysteine and an increased risk of diseases of the cardiovascular system of the human body. We have previously showed that the experimental hyperthyroidism by administration of L-thyroxine to animals is accompanied by a decrease blood levels of homocysteine, an increase in the level of hydrogen sulfide and changes in the activity of enzymes of the metabolism of homocysteine and cysteine.
The aim of the study – to evaluate the effect of vitamins B6, B9, B12 and betaine at levels of cysteine, homocysteine, hydrogen sulfide, and sulfhydryl groups with extended hyper- and hypothyroidism.
Research Methods. The state of extended hyper- and hypothyroidism in experimental rats was modeled by administration to animals of L-thyroxine and mercazolyle, respectively, on the 21st day.
Results and Discussion. It was determined that hyperthyroidism led to a decrease in the blood serum levels of homocysteine and sulfhydryl groups, an increase in the value of “hydrogen sulfide/homocysteine”. Extended hypothyroidism led to an increase in serum levels of cysteine, homocysteine and sulfhydryl groups, a decrease in the level of hydrogen sulfide and the value of “hydrogen sulfide/homocysteine”.
Conclusions. Folic acid, cyanocobalamin, pyridoxine and betaine, when administered in parallel with L-thyroxine, partially prevented a disturbance in the metabolic processes of homocysteine and cysteine and led to an increase in the concentration of hydrogen sulfide and a decrease in the concentration of homocysteine in the blood. At the same time, with hypothyroidism, correction with folic acid, cyanocobalamin, pyridoxine and betaine led to the following changes, the level of homocysteine was significantly reduced, the concentration of cysteine, hydrogen sulfide, sulfhydryl groups and the value of “hydrogen sulfide/homocysteine” increased.
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