A COMPARATIVE ANALYSIS OF THE CARDIOPROTECTIVE PROPERTIES OF CORVITIN AND DRY EXTRACT FROM THE LANCEOLATE HOSTA LEAVES AT ADRENALINE HEART INJURY
DOI:
https://doi.org/10.11603/mcch.2410-681X.2019.v.i4.10838Keywords:
adrenaline, hosta leaf dry extract, corvitin, white ratsAbstract
Introduction. In modern conditions, psycho-emotional stress complicates the course and prognosis of major diseases of the cardiovascular system (coronary heart disease, myocardial infarction, hypertension, atherosclerosis) and can lead to the development of necrotic damage to the myocardium. Studies conducted in recent years by pharmacologists, pharmacists and physicians aimed at finding new herbal remedies with cardioprotective properties with greater efficacy and less toxicity than those currently available in the pharmaceutical market.
The aim of the study – to learn the membrane-protective properties of the dry extract of the hosta lanceolate leaves and indicators of the functioning of the heart in a model of toxic heart damage by adrenaline.
Research Methods. The experiments were performed on 42 white male rats 6 months old of 180–200 g. Necrotic myocardial damage was modeled by a single intramuscular injection of 0.18 % adrenaline hydrotartrate solution at the rate of 0.5 mg/kg. For the purpose of correction, a dry extract was injected daily from the hosta of the lanceolate leaves at a dose of 100 mg/kg body weight and corvitin at a dose of 42 mg/kg daily during the experiment. The study was performed 24 and 48 hours after the administration of adrenaline. Electrocardiograms were recorded and analyzed, and the activity of aspartate aminotransferase and creatine phosphokinase was determined in blood serum and heart.
Results and Discussion. The activity of aspartate aminotransferase and creatine phosphofokinase in the blood serum of rats treated with adrenaline increased throughout the duration of the experiment. The activity of creatine phosphokinase in the blood serum of animals after administration of adrenaline increased: after 24 hours – 2.2 times, after 48 hours – 2.5 times. In the heart of rats, an inverse tendency to a decrease in these indicators was observed. 24 hours after the administration of adrenaline, Corvitin had a positive effect on the activity of enzymes. At the end of the experiment, both corrective factors were effective. Electrocardiograms confirmed the development of myocardial dystrophy in rats that received a toxic dose of adrenaline. By the end of the experiment, both the extract and corvitin showed a positive effect on the electrocardiogram indices in animals, which confirmed their cardioprotective properties.
Conclusions. A cardiotoxic dose of adrenaline leads to cytolysis of cardiocytes and a change in the permeability of plasma membranes, as indicated by an increase in the activity of aspartate aminotransferase and creatine phosphokinase in blood serum and its decrease in the heart. The dry extract of the hosta of the lanceolate leaves and corvitin have a pronounced protective effect on the activity of enzymes. The extract and corvitin, which are introduced against the background of adrenaline damage to the heart, reduce the excitability of the sinus node and decrease the conduction of impulses in the atria and ventricles.
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