THE OXIDATION PROCESSES IN DIFFERENT AGE RATS UNDER THE CONDITIONS OF COMPLEX PERSISTENT EFFECT OF HEAVY METAL SALTS AND PHOSPHORORGANIC PESTICIDES
DOI:
https://doi.org/10.11603/mcch.2410-681X.2019.v.i2.10301Keywords:
oxidative stress, oxidation modification of proteins, lead acetate, copper sulfate, glyphosate, chronic effects, ratsAbstract
Introduction. Lead poisoning is a major public health risk. Lead is an immunotoxicant, it has reproductive toxicity, liver toxicity. Lead, copper and their compounds exhibit cumulative, cytotoxic effects on the body, cause the activation of oxidative stress.
The aim of the study – to research the correction effect of the peptide on the oxidative processes in different age groups of animals by the lead acetate, the copper sulfate, the glyphosate (in herbicide Roundup) poisoning.
Research Methods. Experiments were performed on lab nonlinear white male rats of three age periods: puberty (young, 70–90 g of body weight and aged 2 to 3 months); mature (adult, weighing 170–210 g and aged 5–8 months) and old rats (body weight 250–300 g and aged 20–24 months), which were injected intragastrically for 30 days with the lead acetate, the copper sulfate, the glyphosate (in herbicide Roundup) and underwent the correction of violations of free radical oxidation of lipids and proteins with peptide cysteyl-histidyl-tyrosyl-histidyl-isoleucine. We studied free radical oxidation processes by the content of TBA-active products (TBA-AP), diene conjugates (DC), and oxidation-modified proteins in blood serum (OMP370 and OMP430).
Results and Discussion. The combined effect of lead acetate, copper sulfate and glyphosate on the oxidative modification of proteins and lipids in rats of different age groups was studied. It was established that the studied xenobiotics increase the concentration of TBA-active products, diene conjugates, and oxidative modification of proteins.
Conclusion. It was established that the effect of the lead acetate, the copper sulfate, the glyphosate (in herbicide Roundup) caused oxidative stress in rats, which was accompanied by an increase in the content of free radical oxidation products of lipids and proteins.
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