EVALUATION OF INFLAMMATORY PROCESS LEVEL IN RATS AT EXPERIMENTAL CARCINOGENESIS AND EFFECT OF ENTESORPTION ON THEM
DOI:
https://doi.org/10.11603/mcch.2410-681X.2019.v.i2.10290Keywords:
inflammatory processes, proinflammatory interleukins, anti-inflammatory interleukins, sorbent AUTAbstract
Introduction. The problem of increasing malignant tumors of the colon is one of the most urgent in the field of medicine. The object of attention in the study of carcinogenesis of the large intestine is the state of the immune system of the organism and the activation of inflammatory processes in experimental animals. For the normalization of indicators of inflammation, methods of detoxification therapy are promising, namely enterosorption.
The aim of the study – to evaluate changes in the level of markers of inflammation in the blood of experimental animals with chemically induced carcinogenesis and the dynamics of their changes when introducing a carbon enterosorbent AUT.
Research Methods. The studies were conducted on white male rats. Animals were modeled colon cancer by administering 1,2=dimethylhydrazine hydrochloride at a dose of 7.2 mg/kg of body weight for 30 weeks. Enterosorbent AUT was injected intragastrally daily for 21 days after the carcinogenesis modeling in a dose of 1 ml of curd (corresponding to 0.2 g of pure weight of the drug) per 100 g of animal body weight. The activity of inflammatory processes was assessed by concentration of proinflammatory interleukin-6, interleukin 4 and C-reactive protein in the blood serum of experimental animals.
Results and Discussion. It was established that the administration of 1.2 dimethylhydrazine hydrochloride to animals is accompanied by a change in the cytokine profile and the content of C-reactive protein. There was an increase in pro-inflammatory interleukin 6, a decrease in anti-inflammatory interleukin 4 and an increase in the content of C-reactive protein in all terms of the study. The use of an enterosorbent AUT improved the results.
Conclusion. The obtained results confirm the positive dynamics of the use of detoxification therapy with sorbent AUT during the progressive development of inflammatory processes in conditions of simulated carcinogenesis.
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