Keywords: chronic obstructive pulmonary disease, oxidative stress, mechanisms


Introduction. The prevalence of chronic obstructive pulmonary disease (COPD) continues to grow steadily and according to researchers, by 2030 this disease will be the third most significant cause of death. The pathophysiology of COPD is complicated and largely unexplored. Most researchers in patients with COPD determine local and systemic changes that include oxidative stress, changes in levels of acute phase proteins and inflammatory mediators, although there is no single point of view regarding their role in this disease.

We used general scientific research methods.

Researchers noted that peroxide oxidation of proteins is not only a trigger mechanism for pathological stress, but also one of the earliest markers of oxidative stress and reflects the degree of oxidative cell damage and reserve adaptive capacity of the body in case of COPD. Oxidative stress leads to the oxidation of arachidonic acid and the formation of a new generation of prostanoic mediators, the so-called isoprostants, which can exhibit pronounced functional effects, including bronchoconstriction and plasma exudation.

To counteract the negative effects of oxidative stress in the body, there are an enzyme and non-zinc levels of the antioxidant defense system. High antioxidant efficacy is manifested by copper-zinc-containing SOD, gem-containing catalase, selenium-containing glutathione peroxidase. Analysis of literary sources suggests that the internal antioxidant glutathione is a loud protective system in the epithelium of the lungs. The protective effects of a related antioxidant system, established in the epithelium, are surprisingly regulated by the genes. This can be one of the reasons why only 10 % of people who smoke has COPD.

The aim of the study – to analyze modern literary sources about the role of free radical processes in the mechanisms of development of chronic obstructive pulmonary disease.

Conclusion. The analysis of literature data showed that oxidative stress plays an important role in the pathogenesis of chronic obstructive pulmonary disease, but the mechanisms of its influence require a more detailed and in-depth study.


Khrystych, M., Fediv, O.I., Teleki, Ya.M., & Olinyk, O.Yu. (2011) Rol tsytokinovoho dysbalansu v rozvytku ta prohresuvanni khronichnoho obstruktyvnoho zakhvoriuvannia lehen iz suputnim khronichnym pankreatytom [The role of cytokine imbalance in the development and progression of chronic obstructive pulmonary disease with concomitant chronic pancreatitis]. Novosti meditsyny i farmatsyi. Hastroenterologiya. – Medicine and Pharmacy News. Gastroentherology, 382 [in Ukrainian].

Bhandari, R., & Sharma, R. (2012). Epidemiology of chronic obstructive pulmonary disease: a descriptive study in the mid-western region of Nepal. International Journal of COPD, 7, 253-257.

Pertseva, T.A. (2011). Epidemiologiya i diagnostika khronicheskogo obstruktivnogo zabolevaniya legkikh [Epidemiology and diagnosis of chronic obstructive pulmonary disease]. Ukr. pulm. zhurn. – Ukrainian Pulmonology Journal, 2, 20 [in Russian].

Alwan, A. (2010) . Global Status Report on Non-Communicable Diseases. Global status report on noncommunicable diseases, 176.

Bigna, J., Kenne, A.M., Asangbeh, S.L., & Sibetcheu, A.T. (2018). Prevalence of chronic obstructive pulmonary disease in the global population with HIV: a systematic review and meta-analysis. Lancet Glob Health, 6, 193–202.

Stone, H., Nab, G.M., & Wood, A.M. (2012). Variability of sputum inflammatory mediators in COPD and α1-antitrypsin deficiency Eur. Respir. J., 40, 561-569.

Marushchak, M., Krynytska, I., Petrenko, N., & Klishch, I. (2016). The determination of correlation linkages between level of reactive oxygen species, contents of neutrophiles and blood gas composition in experimental acute lung injury Georgian Med. News, 253, 98-103.

Tuder, M.R., & Petrache, I. (2012). Pathogenesis of chronic obstructive pulmonary disease. J. Clin. Invest., 122 (8), 2749-2755.

Kohen, R., & Nyska, A. (2002). Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicol. Pathol., 30(6), 620-650.

Shishko, G.A., Sapotnitskiy, A.V., & Ustinovich, Yu.A. (2011). Rol oksidativnogo stressa v patogeneze zabolevaniy novorozhdennykh detey [The role of oxidative stress in the pathogenesis of diseases of newborns]. Belorusskaya meditsinskaya akademiya poslediplomnogo obrazovaniya – Belarusian Medical Academy of Postgraduate Education, 6, 22-24 [in Russian].

Mishra, O. P., & Papadopoulos, M.D. (1999). Cellular mechanisms of hypoxic injury in the developing brain. Brain Res.. Bull., 48, 233-238.

Li, X., Fang, P., & Mai, J. (2013). Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers. J. Hematol. Oncol., 6, 1-19.

West, A. P., Shadel, G.S., & Ghosh, S. (2011). Mitochondria in innate immune responses. Nat. Rev. Immunol., 11(6), 389-402.

Dada, L.A., & Sznajder, J.L. (2011). Mitochondrial Ca2+ and ROS take center stage to orchestrate TNF-α–mediated inflammatory responses. J. Clin. Invest, 121 (5), 1683-1685.

Balabolkin, M.I., Kreminskaya, V.M., & Klebanova, E.M. (2005). Rol okislitelnogo stressa v patogeneze diabeticheskoy neyropatii i vozmozhnost yego korrektsii preparatimi a-lipoyevoy kisloty [The role of oxidative stress in the pathogenesis of diabetic neuropathy and the possibility of its correction by preparations of α-lipoic acid]. Problemy endokrinologii – Problems of Endocrinology, 51 (3), 22-33 [in Russian].

Klymenko, M.O., Subota, N.P., & Netiukhailo, L.H. (2006). Nefermentatyvna lanka antyoksydantnoi systemy v rizni stadii eksperymentalnoi opikovoi khvoroby pry vykorystanni preparatu Kriokhor [Non-enzymatic link of antioxidant system at different stages of experimental burn disease with the use of the drug Cryochorus]. Eksperymentalna i klinichna medytsyna – Experimental and Clinical Medicine, 1, 13-17 [in Ukrainian].

Imaizumi, Y., Eguchi, K., & Kario, K. (2015). Lung disease and hypertension. Pulse, 2 (1-4), 103-112.

Romero, P.V., Rodríguez, B., & Martínez, S. (2006). Analysis of oxidative stress in exhaled breath condensate from patients with severe pulmonary infections. Archivos de Bronconeumologia, 42 (3), 113-119.

Zhang, W., Wei, H., & Frei, B. (2009). Genetic deficiency of NADPH oxidase does not diminish, but rather enhances, LPS-induced acute inflammatory responses in vivo. Free Radical Biology and Medicine, 46 (6), 791-798.

Mills, M.C., Marchese, M.E., & Valencia, H.A. (2011). Vascular cell adhesion molecule-1 expression and signaling during disease: regulation by reactive oxygen species and antioxidants. Antioxidants & Redox Signaling, 15 (6), 1607-1638.

Bhoite, G.M., Pawar, S.M., Bankar, M.P., & Momin, A.A. (2011). Level of antioxidant vitamins in children suffering from pneumonia, 15(1). Retrieved from:

Netiukhailo, L.H., & Kharchenko, S.V. (2014). Aktyvni formy kysniu (ohliad literatury) [Active forms of oxygen (review of literature)]. Young Scientist, 9 (12), 131-135 [in Ukrainian].

Vaidya, N.A., & Bulakh, P.M. (2013). Antioxidant enzymes and antioxidants in children with. IOSR Journal of Dental and Medical Sciences, 8(6), 01-05.

Churchill Livingstone. (2005). Principles and practice of infectious diseases. Young EJ, 2669-2672.

Klymenko, M.O., & Netiukhailo, L.H. (2009). Opikova khvoroba (patohenez i likuvannia) [Burn disease (pathogenesis and treatment)]. Monohrafiia – Monograph [in Ukrainian].

Montuschi, P., Barnes, P.J., & Roberts, L.J. (2004). Isoprostanes: markers and mediators of oxidative stress. FASEB J, 18, 1791-800.

Rezaeetalab, F., Alamdari, D.H., & Dalili, A. (2017). Prooxidant - Antioxidant balance in COPD patients. Pneumologia, 66 (2), 90-93.

Rogers, D.F., Chadwick, D., & Goode, J.A. (2001). Mucus hypersecretion in chronic obstructive pulmonary disease. Chronic obstructive pulmonary disease: pathogenesis to treatment, 65-83.

Nadel, J.A. (2001). Role of epidermal growth factor receptor activation in regulating mucin synthesis. Respir. Res., 2, 85-89.

Rezaeetalab, F., Alamdari, D.H., & Dalili, A. (2014). Oxidative stress in COPD, pathogenesis and therapeutic views. Treat Respir. Med., 1(3), 115-124.

Higgins, M., & Thom, T. (1990). Incidence, prevalence, and mortality: intra- and inter-county differences. Clinical epidemiology of chronic obstructive pulmonary disease, 23-43.

Malhotra, D., Casamar, E.P., & Singh, A. (2010). Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network. Nucleic Acids Res, 38 (17), 5718-5734.

Tuder, R.M., & Petrache, I. (2012). Pathogenesis of chronic obstructive pulmonary. J. Clin. Invest., 122 (8), 2749-2755.

How to Cite
Maksiv, C., & Marushchak, M. (2019). THE ROLE OF OXIDATIVE STRESS IN THE DEVELOPMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASES. Medical and Clinical Chemistry, (1), 120-125.