GENDER FEATURES OF THE FATTY ACIDS AND LIPID SPECTRUM OF PLASMA IN TRANSCARPATHIAN PLAIN DWELLERS WITH DIFFERENT TROPHOLOGICAL STATUS
Introduction. In the human body, about half of all energy is formed by oxidation of higher fatty acids. At present, the number of studies that are studying changes in the fatty acid and lipid plasma spectrum, depending on altitude of living and body mass index (BMI), is limited.
The aim of the study – to identify the gender characteristics of the fatty acid and lipid plasma spectrum in the inhabitants of flat inhabited areas of the Transcarpathian region with overweight and obesity.
Research Methods. 107 persons with different trophological status, inhabitants of Uzhhorod district of Zakarpattia region (plain settlements) were investigated, in which indicators of fatty acid and lipid spectrum were determined.
Results and Discussion. Lipid spectrum levels in women were worse than in men due to the higher level of TC and LDL cholesterol. Women showed higher levels of saturated fatty acid due to palmitic ((765.00±30.60) μg/ml versus (644.50±40.00) μg/ml among men, p=0.02) and stearinic fatty acid (214.80±10.30) μg/ml versus (175.70±9.00) μg/ml for men, p=0.01). In addition, women had significantly higher total polyunsaturated fatty acid levels compared to men (1546.40±39.90) μg/ml versus (1214.00±53.10) μg/ml, p<0.01), primarily due to a higher level of ω6- polyunsaturated fatty acid (1446.60±37.20) μg/ml versus (1132.90±49.10); p<0.01).
Conclusions. Women had the worst lipid plasma parameters, higher levels of individual saturated fatty acids, higher total polyunsaturated fatty acid levels, and higher levels of ω6-polyunsaturated fatty acid, indicating a higher predisposition for atherogenesis and development of proinflammatory vascular changes. Such results can be partially explained by premenopausal and early menopause in the examined women.
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