THE INFLUENCE OF THYROID HORMONES ON PROTEIN OXIDATIVE MODIFICATION IN CASE OF EXPERIMENTAL PERIODONTITIS

  • V. V. Shcherba I. HORBACHEVSKY TERNOPIL STATE MEDICAL UNIVERSITY
  • T. Ya. Yaroshenko I. HORBACHEVSKY TERNOPIL STATE MEDICAL UNIVERSITY
  • R. M. Kubant TORONTO UNIVERSITY
  • M. M. Korda I. HORBACHEVSKY TERNOPIL STATE MEDICAL UNIVERSITY
Keywords: periodontitis, thyroid hormones, protein oxidative modification

Abstract

Introduction. The inflammatory-dystrophic process in periodontium is accompanied by its hypoxia, which causes the activation of free radical oxidation processes. Tissue destruction in periodontal diseases is considered to be the result of an altered inflammatory/immune response to microbial plaque and involves massive release of neutrophils, reactive oxygen species and enzymes.

The aim of the study to establish the protein oxidative modification in blood and periodontium in case of periodontitis combined with hyper- and hypothyroidism in rats.

Research Methods. Experimental studies were carry out on 48 mature male, nonliner, white rats, which were divided into the following groups: І – control animals; ІІ – animals with periodontitis; ІІІ – animals with periodontitis combined with hyperthyroidism; IV – animals with periodontitis combined with hypothyroidism. Protein oxidative modification (POM) was determined in blood serum and periodontium homogenate by the method of I.F. Meschyshyn.

Results and Discussion. The results of our studies showed that the intensity of the processes of protein oxidative modification was significantly increased in animals of all experimental groups vs control group. The content of aldehyde- and ketone derivatives of the alkali nature changed more pronounced than the content of aldehyde and ketone derivatives of neutral nature.

Conclusions. Thus, the experimental periodontitis is accompanied by a marked increase in the intensity of the protein oxidative modifications both in the homogenate of periodontal tissues and in the blood serum. Imbalance of thyroid hormones increases oxidative stress in experimental periodontitis, especially pronounced in hyperthyroidism.

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Published
2019-01-31
How to Cite
Shcherba, V., Yaroshenko, T., Kubant, R., & Korda, M. (2019). THE INFLUENCE OF THYROID HORMONES ON PROTEIN OXIDATIVE MODIFICATION IN CASE OF EXPERIMENTAL PERIODONTITIS. Medical and Clinical Chemistry, (4), 52-59. https://doi.org/10.11603/mcch.2410-681X.2018.v0.i4.9791
Section
ORIGINAL INVESTIGATIONS