DETERMINATION OF EXPECTORANT ACTIVITY OF TABLETS BASED ON THE WILD MALLOW FLOWERS AND PLANTAIN LANCEOLATE EXTRACTS
Introduction. According to recent WHO data, today the disease of the respiratory system is the leading cause of death and disability in the world. In accordance with the formular system of Ukraine (2009), the treatment of acute broncho-pulmonary diseases of an infectious origin begins with etiotropic agents, which are joined by pathogenetic monotherapy. This group includes herbal preparations and preparations with resorptive action.
The aim of the study – to learn the expectorant properties of tablets, which include extracts of wild mallow flowers and plantain lanceolate.
Materials and Methods. Healthy male mice BALB/c (20-25 g) were used for the experiment. After 10 days of adaptation, the animals were randomly divided into groups of 6 mice in each, and appropriate preparations were introduced to animals with an atraumatic probe intragastrally: group 1 – distilled water, group 2 – a solution of ammonium chloride (1.0 g/kg body weight), group 3, 4, 5 – dissolved extracts of wild mallow flowers 0.062 g/kg, plantain lanceolate 0.062 g/kg and the test tablets .4819 g/kg, respectively. The intraperitoneal solution of phenol red (5 % in physiological saline, 0.1 ml/10 g body weight) was injected into the mice after 30 minutes from the last injection. After ultrasound treatment of isolated organs 0.1 ml of 1 M sodium hydroxide solution was added to these organs for 10 minutes. A spectrophotometer Lambda 25 (Perkin Elmer, USA) was used to measure the optical density of the resulting solution at a wavelength of 546 nm.
Results and Discussion. The results of studies have shown that the administration of ammonium chloride, extracts of wild mallow flowers and plantain lanceolate, tablets to experimental animals stimulated the secretory function of the bronchi. This experimental model made it possible to characterize the expectorant properties of the studied drug and determine its effect on the secretory function of the bronchi: the expectorant capacity of the test substance was 40.16 % higher than the expectorant capacity of the comparison preparation (ammonium chloride).
Conclusions. Therefore, based on the above data, the studied tablets have a high ability to secrete sputum, a good therapeutic activity and may be recommended for further research as a potential drug with expectorant properties.
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