INFLUENCE OF L-ARGININ DRUGS ON THE CHANGE OF LIPID PEROXIDATION AND ANTIOXIDANT SYSTEMS IN BLOOD UNDER CONDITIONS OF COMBINATION PATHOLOGY – IMMOBILIZATIONAL STRESS AND ADRENALIN DAMAGE OF MYOCARDIUM
Introduction. The activation of adrenergic and hypothalamic-pituitary-adrenal systems leads to the Selye stress triad, the first component of which is argenal gland hypertrophy and increased synthesis of glucocorticoids and catecholamines. Arginine is a necessary component for the synthesis of proteins and number of biologically important molecules, such as ornithine, proline, polyamines, creatine and agmatine. However, the main role of arginine in human body – to be a substrate nitrogen oxide synthesis.
The aimof the study – to learn the effect of L-arginine on changes in the processes of lipid peroxidation and antioxidant system in the blood of white rats under the influence of acute immobilization stress and adrenaline.
Research Methods. The experiment was carried out on white male rats of the Vistar line weighing 180–200 g, which were divided into 3 groups (two experimental and one control, 10 animals in each).
Results and Discussion. It was revealed that under conditions of combined pathology of immobilization stress and adrenal damage of myocardium before treatment with L-arginine, blood activity in the antioxidant system of catalase and superoxide dismutase decreased in the 5th day of the experiment. The increase of the products of LP – diene conjugates and malonic aldehyde was established. 5days administration of L-arginine results in increased activity of CT (107.2 %) and SOD (74.5 %) in comparison with a group of animals with a combined pathology in the experiment (IS + AIM) prior to treatment, indicating the antioxidant effect of the drug. The use of L-arginine for 5 days reduced the content of diene conjugates by 80.16 % (p <0.05) and MDA by 42.26 % (p <0.05), indicating a decrease in lipid peroxidation processes.
Сonclusion. Consequently, L-arginine is expedient in the future and perspective to be studied in the experiment and clinic in order to correct metabolic disorders in the conditions of experimental IC and APM and to develop methodological recommendations.
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