THE EFFECT OF PEPTIDES ON THE STATE OF IMMUNE SYSTEM OF THE BODY AND CONTENT OF PROTEIN FRACTIONS IN BLOOD OF RATS AFFLICTED BY SALTS OF HEAVY METALS AND ROUNDUP

  • M. M. Korda I. HORBACHEVSKY TERNOPIL STATE MEDICAL UNIVERSITY
  • Ye. B. Dumukhalska I. HORBACHEVSKY TERNOPIL STATE MEDICAL UNIVERSITY
  • T. Ya. Yaroshenko I. HORBACHEVSKY TERNOPIL STATE MEDICAL UNIVERSITY
Keywords: immune system, immunoglobulins, protein’s fractions, Plumbum acetate, Cuprum sulfate, glyphosate

Abstract

Introduction. Lead is a protoplasmic poison and has detrimental effects on the nervous, cardiovascular system and blood as all heavy metals. It violates enzymatic reactions, depress the immunobiological resistance of the body. Lead affects humoral immune response, that is impairment of antibody production, inhibits the production of M, E and A immunoglobulins classes and increases respiratory diseases frequency in people affected by Plumbum compounds.

The aim of the study to reseach the effect of cystile-histidyl-tyrosyl-histidil-isoleucine peptide on the immune system state and content of protein fractions in blood serum in all ages rats with chronic toxicosis, heavy metals and glyphosate.

Research Methods.Experiments were carried out on laboratory nonlinear white male rats of three age groups: puberty, mature and old animals, which were injected intragastrically for 30 days with Plumbum acetate, Cuprum sulfate, glyphosate (in the form of a herbicide roundup). For the purpose of correction for 21 days 6 hours after the administration of the toxicants for 10 days, the cystile-hystidyl-tyrosyl-histidil-isoleucine peptide was injected. The state of the immune system was assessed by the level of A, M, G immunoglobulins and circulating immune complexes in the blood serum of rats.

Results and Discussion.It was established that in intact rats when combined action of Plumbum acetate, Cuprum sulfate, glyphosate (in the form of a herbicide roundup), the concentration of circulating immune complexes (CIC) and immunoglobulins in the blood serum of animals increased with age. The introduction of the peptide leads to partial restoration of the ratio of protein fractions in blood serum of rats and the content of immunoglobulins.

Conclusion. The use of the peptide as a correction factor partially normalizes the state of the immune system and the ratio of protein fractions in blood serum of rats with toxicosiscaused by Plumbum acetate, Cuprum sulfate and the roundup.

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Published
2018-11-08
How to Cite
Korda, M., Dumukhalska, Y., & Yaroshenko, T. (2018). THE EFFECT OF PEPTIDES ON THE STATE OF IMMUNE SYSTEM OF THE BODY AND CONTENT OF PROTEIN FRACTIONS IN BLOOD OF RATS AFFLICTED BY SALTS OF HEAVY METALS AND ROUNDUP. Medical and Clinical Chemistry, (3), 70-75. https://doi.org/10.11603/mcch.2410-681X.2018.v0.i3.9568
Section
ORIGINAL INVESTIGATIONS