RESEARCH THE HYPOGLICEMIC ACTIVITY OF THE HERBAL REMEDY THAT CONTAIN DRY EXTRACTS OF WHITE MULBERRY LEAVES, COMMON BEAN SHELLS AND BLUEBERRY SPROUTS

  • А. І. Dub I. HORBACHEVSKY TERNOPIL STATE MEDICAL UNIVERSITY
  • І. М. lishch I. HORBACHEVSKY TERNOPIL STATE MEDICAL UNIVERSITY
  • L. V. Vronska I. HORBACHEVSKY TERNOPIL STATE MEDICAL UNIVERSITY
  • I. P. Stechyshyn I. HORBACHEVSKY TERNOPIL STATE MEDICAL UNIVERSITY
Keywords: diabetes mellitus, dry extract; mulberry white, blackberry common, bean common, oral glucose tolerance test

Abstract

Introduction. Diabetes mellitus is a social catastrophe that deprives life of millions of people and the worst trend is that two-thirds of them are employable population. The search for new hypoglycemic agents is an actual problem task of modern pharmacy, despite the fact that the modern pharmaceutical market is represented by a broad drugs arsenal of used for the prevention and treatment of diabetes mellitus patients with. Due to a complex of biologically active substances in plants, herbal remedies manifest a multifaceted action on the human body, thus ensuring the influence on various stages of development of diabetes and its specific and non-specific complications, with a minimal risk of toxic or allergic influence and can be like an alternative for synthetic hypoglycaemic drugs.

The aim of the study – to research the hypoglycemic action of the herbal remedy (a combination of dry extracts of white mulberry (Morus alba L.) leaves, common bean (Phaseolus vulgaris L.) shells and blueberry (Vaccinium myrtillus L.) sprouts.

Research Methods. The research was conducted on Wistar male rats, which received intragastrically phyto remedies preventively during 7 days in different doses. An infusion of “Arphazetin”, a suspension of tablets “Metformin” were used as reference substances. The determination of glucose concentration in the blood of animals was initiated (before and after usage of the appropriate extracts), as well as during the condition of the oral glucose tolerance test.

Results and Discussion. There was a decrease of basal glycemia after seven days of prophylactic administration, as well as a decrease of glycemia in the condition of an oral glucose tolerance test, in all experimental groups that received phyto remedies. The hypoglycemic action of a phyto remedies in a dosage of 100 mg/kg of dry extract of leaves of mulberry white is comparable to the effect of the drug “Metformin” and significantly exceeds the effect of infusion from the medicinal collection of "Arphasitin".

Conclusions. The obtained results of the study indicate the expressed hypoglycemic effect of phyto remedies, containing dry extracts of leaves of mulberry, leaflets of common bean and sprouts of blackberry common. Further study of the hypoglycemic effect of the investigated phyto remedies will be carried out in the chosen dosage at the rate of 100 mg/kg of dry extract leaves of mulberry white.

Author Biographies

А. І. Dub, I. HORBACHEVSKY TERNOPIL STATE MEDICAL UNIVERSITY

кафедра управління та економіки фармації з технологією ліків

I. P. Stechyshyn, I. HORBACHEVSKY TERNOPIL STATE MEDICAL UNIVERSITY

Тернопільський державний медичний університет імені І. Я. Горбачевського

References

International Diabetes Federation (2017). IDF Dia­betes Atlas. Retrieved from: http://www.diabetesatlas.org/.

MOZ Ukrainy, DU “UISD MOZ Ukrainy”. (2017). Shchorichna dopovid pro stan zdorovia naselennia, sanitarno-epidemichnu sytuatsiiu ta rezultaty diialnosti systemy okhorony zdorovia Ukrainy. 2016 rik [Annual report on the health status of the population, the sanitary and epidemiological situation and the results of the health care system of Ukraine. 2016 year]. Kyiv [in Ukrainian].

Nakaz MOZ Ukrainy “Pro zatverdzhennia ta vprovadzhennia medyko-tekhnolohichnykh dokumentiv zi standartyzatsii medychnoi dopomohy pry tsukrovomu diabeti 2 typu” [Order of the Ministry of Health of Ukraine "On Approval and implementation of medical-technolo­gical documents for the standardization of medical aid in type 2 diabetes" No. 1118] [in Ukrainian].

Ezhned, M.A., Hroshovyi, T.A., & Horoshko, O.M. (2015). Osoblyvosti tsukroznyzhuvalnoi dii sukhoho ekstraktu z koreniv i korenevyshch omanu vysokoho zalezhno vid dozy [Features of hypoglycemic effect of dry extract from the elecampane roots and rhizomes depending on the dose]. Farmatsevtychnyi chasopys – Pharmaceutical Journal, (3), 63-65 [in Ukrainian].

Savych, A.O. (2017). Farmakolohichne ta fitokhimichne obhruntuvannia vykorystannia antydiabetychnoho roslynnoho zboru v terapii tsukrovoho diabetu [Pharmacological and phytochemical justification for the use of antidiabetic herbal collection in the treatment of diabetes]. Candidate’s thesis. National University of Pharmacy, Kharkiv [in Ukrainian].

Horbulinska, O. V. (2017). Biokhimichni zminy v klitynakh krovi shchuriv za umov vvedennia ekstraktiv ta suspenzii yakona (Smallanthus sonchifolius Poepp. & Endl.) za tsukrovoho diabetu 1-ho typu [Biochemical changes in rats peripheral blood cells under yacon (Smallanthus Sonchifolius Poepp. & Endl.) water extracts and suspensions administration and under diabetes mellitus type 1]. Candidate’s thesis. I. Franko Lviv Naional University [in Ukrainian].

Stefanov, A.V. (Ed.). (2002). Doklinicheskie issledovaniya lekarstvennykh sredstv [Preclinical studies of medicinal products]. Kiev: Avitsenna [in Russian].

Published
2018-11-07
How to Cite
DubА., lishchІ., Vronska, L., & Stechyshyn, I. (2018). RESEARCH THE HYPOGLICEMIC ACTIVITY OF THE HERBAL REMEDY THAT CONTAIN DRY EXTRACTS OF WHITE MULBERRY LEAVES, COMMON BEAN SHELLS AND BLUEBERRY SPROUTS. Medical and Clinical Chemistry, (3), 44-49. https://doi.org/10.11603/mcch.2410-681X.2018.v0.i3.9313
Section
ORIGINAL INVESTIGATIONS