Reactive arthritis imunopathogenesis
Introduction. It is known, that reactive arthritis is one of the widespread joints pathology. In recent years an increase in the number of patients with this pathology has been observed. Causative factors of reactive arthritis are completely unexplored today, the question of pathogenesis of reactive arthritis remains for discussions. Inflamatory diseases of joins, wich are developing due to immune disorders after urogenital, intestinal or respiratory infection belong to reactive arthritis.
The aim of the study – to learn the functional activity of cells of phagocytic system (monocytes and neutrophils of peripheral blood) and detection of diagnostic value of phagocytic reactions in cases of reactive arthritis.
Research Methods. The investigations were conducted on blood samples, of patients with reactive arthritis (n=20) and healthy donors (n=12). The phagocytic activity of neutrophils was determined using method based on endocytosis latex particles by phagocytes, which are visualized in cytoplasm of cells in form of round granules with blue color. Test with nitro blue tetrazolium (NBT-test) was carried out according to the change of color NBT in presents of reactive oxygen species. The counting of neutrophils with blue color granules allows to determine fraction of neutrophils with reactive oxygen species.
Results and Discussion. Trigger factor causing development of reactive arthritis mostly is Chlamidia trachomatis (36 %). Patients with this pathology have statistically significant changes of functional metabolic activity of neutrophils and monocytes of blood. By such indicators as amount of white blood cells, monocytes and neutrophils in peripheral blood and phagocytic activity in cases of reactive arthritis signs of inflammation have been detected.
Conclusion. Received data testify about decreased phagocytic activity of neutrophils and monocytes of blood with the development of reactive arthritis.
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