Investigation of some indices of cellular immunity in patients with common psoriasis
Keywords:, psoriasis, immunity, apoptosis, T-lymphocytes, B-lymphocytes, apoptosis factor FASx, endotheline-1.
Introduction. Immune disorders play an important role in the pathogenesis of psoriasis. So, despite the fact that the data of immunological studies are very numerous, they are sometimes contradictory and not comparable, which is probably connected with the use of different methodological approaches, without taking into account clinical features of the disease, stage of the process, accompanied by a pathology.
The aim of the work – to investigate some parameters of cellular immunity in patients with common psoriasis.
Methods of the research. The following indices: content of T-lymphocytes (CD 3+) T-lymphocytes helper cells (CD4), T cytotoxic cells (CD8), B lymphocytes (CD 19), the factor of apoptosis FASx, endotheline-1 were measured.
Results and Discussion. Analysis of cellular immunity in patients with psoriasis indicates an increase, when compared with healthy patients, T-lymphocytes (BG3+) T-lymphocytes helper cells (CD4), T cytotoxic cells (CD8), with progressive and inpatient stages of the disease. It was found that patients in the progressive stage of cell death significantly increased. In patients with progressive stage of psoriasis revealed an increased content of polypeptide–endothelin that indicates, on the one hand, the violation of vascular endothelium in psoriasis, and on the other, rate of tissue differentiation and apoptosis.
Conclusions. The data obtained indicate significant changes of parameters of cellular immunity in patients with advanced stage.
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