Study of inhibitors for nitric oxide synthase its synthesis in tissues of rats with toxic liver damage

T. Ya. Yaroshenko


There were studied the changes of content of NO-synthase and metabolism products of nitrogen oxide in experimental hepatitis during treatment with inhibitors of its synthesis. According to the results of our research, the use of non-selective inhibitor L-NAME and selective one (1400W) eed to decrease of total activity of NO-synthase and content of nitrates and nitrites in the blood and liver of rats, but it’s significantly increased as a result of intoxication by allyl alcohol. It was determined that intensive iNOS expression and NO hyper production in toxic hepatitis, plays a negative role, whereas NO, is synthesized with constitutional NOS (generally concentrated in the endothelium of the capillaries) displayed a protective function, by improving microcirculation in the parenchyma and minimizing a toxic hepatitis.


nitric oxide; inducible NO-synthase; N-nitro-L-arginine; N- (3- (amynomethyl) benzyl) acetamidine.


Iwakiri Y. Nitric oxide in liver diseases / Y. Iwakiri, M. Y. Kim / Trends Pharmacol. Sci. – 2015. – 36. P. 524–536.[PMC free article] [PubMed]

Regulation of the expression of inducible nitric oxide synthase / A. Pautz, J. Art, S. Hahn [et al.] // Nitric Oxide. – 2010. – 23. – P. 75–93. [PubMed]

The role of iNOS in cholesterol-induced liver fibrosis / S. Anavi, M. Eisenberg-Bord, M. Hahn-Obercyger [et al.] // Lab. Invest. – 2015. – 95. – P. 914–924. [PubMed]

Korda M. M. Vplyv inhibitora indutsybelnoi syntazy oksydu azotu N-(3-(Aminometyl)benzyl)atsetamidynu na hepatotoksychnist alilovoho spyrtu / M. M. Korda, T. Ia. Yaroshenko // Med. khimiia. – 2004. – 6, № 3. – S. 114–116.

Yaroshenko T. Role of nitric oxide in chemically induced hepatotoxicity / T. Yaroshenko, M. Korda // Ann. Univers. Mariae Curie-Sklodowska. – 2006. – 19, Nо. 3. – P. 143–146.

Yaroshenko T. Ia. Korektsiia vyklykanoho alilovym spyrtom urazhennia pechinky za dopomohoiu poiednanoho zastosuvannia inhibitora indutsybelnoi syntazy oksydu azotu 1400W i substratu syntazy oksydu azotu L-arhininu / T. Ia. Yaroshenko, M. M. Korda // Med. ximiia. – 2007. – 9, № 4. – S. 24–27.

Malinski T., Taha Z. Nitric oxide release from a single cell measured in situ by a porphyrinic based microsensor // Nature. – 1992. – № 358. – P. 676–678.

Kiselyk I. O. Osoblyvosti vyznachennia nitrativ ta nitrytiv v peryferychnii krovi u khvorykh na virusni hepatyty ta pry syndromi zhovtianytsi inshoi etiolohii / I. O. Kiselyk, M. D. Lutsyk, L. Iu. Shevchenko // Lab. diahnostyka. – 2001. – № 3. – S. 43–45.



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