Role of estrogens in the mechanism of oxidative impact of cranio-skeletal injury in the late period of traumatic disease

  • A. S. Mashevskyi
Keywords: gonadectomy, estrogen, lipid peroxidation, skeletal trauma, traumatic brain injury.

Abstract

In terms of removing over after 1 month in liver tissue there was observed strengthening of lipid peroxidation, accompanied by an increase in the content of TBA-active products of lipid peroxidation. In brain tissue, these processes almost were not expressed. After application of skeletal injuries in terms of removing more than an increase in the content of secondary products of lipid peroxidation after 1 month post-traumatic period after combined injury and it remains elevated after 2 months, due to the severity of the injury and the depth of systemic disorders. Brain tissue against the backdrop of estrogen deficiency is characterized by greater resistance to oxidative impact injury. Compared with animals without removing bigger intensification of processes of lipid peroxidation was observed only after 1 month of post-traumatic period.

References

Borys, R. M. (2013). Morfolohichni i biokhimichni zminy vnutrishnikh orhaniv pry eksperymentalnii kranioskeletnii travmi. Ternopil. TDMU, 142.

Dziuba, D. A., Malыsh, Y. R., & Zghrzheblovskaia, L. V. (2008). Pokazately aktyvatsyy apoptoza v techenyy polytravmы tiazheloi stepeny. Ukr. zhurn. ekstremal. medytsyny imeni H. O. Mozhaieva, 1, 53–58.

Stefanova, O. V. (2001). Doklinichni doslidzhennia likarskykh zasobiv. K. Avitsenna, 528.

Elskyiy, V. N., & Ziablytsev, S. V. (2008). Modelyrovanye cherepno-mozghovoi travmy. Donetsk. Novyi myr, 140.

Kamyshnykov, V. S., Kovalenko, Yu. D., & Kokhnovych, N N. (2003). Klynyko-laboratornyi monytorynh byokhymycheskykh markerov osteoporoza v eksperymente. Dostyzhenyia medytsynskoi nauky Belarusy. http://med.by/dmn/book.php?book=03-18_10.

Servatovych, A. M. (2015). Dynamika porushen protsesiv lipidnoi peroksydatsii v period piznikh proiaviv travmatychnoi khvoroby pislia kranioskeletnoi travmy ta efektyvnist yii korektsii fitozborom. Visn. nauk. Doslidzh, 4, 106–109.

Kharchenko, V. V. (2007). Pryrodni bioantyoksydanty ta pechinka. Suchasna hastroenterol, 6, 79–85.

Published
2016-11-21
How to Cite
Mashevskyi, A. S. (2016). Role of estrogens in the mechanism of oxidative impact of cranio-skeletal injury in the late period of traumatic disease. Medical and Clinical Chemistry, (3), 92-95. https://doi.org/10.11603/mcch.2410-681X.2016.v0.i3.6952
Section
ORIGINAL INVESTIGATIONS