THE INFLUENCE OF HEAVY METAL S, ORGANOPHOSPHATE PESTICIDES AND PEPTIDES ON THE ENZYME ACTIVITY OF GLUTATHIONE SYSTEM

Authors

  • Ye. B. Dmukhalska
  • Ya. I. Honsky

DOI:

https://doi.org/10.11603/mcch.2410-681X.2016.v0.i1.6187

Abstract

The reduced glutathione content and the glutathione metabolism enzymes activity in organs and blood plasma of rats under conditions of lead acetate, copper sulphate and glyphosate in Roundup form were studied. The glutathioneperoxidase, the glutathionereductase activity and the concentration of glutathione decreases during action of heavy metals and glyphosate. It was found out that peptide exhibits antioxidant activity, the correction of the peptide and glutathione content.

References

Aksenova ME Heavy metals: Mechanisms nefrotoksichnosti (review of literature) / ME Aksenova // Nephrology and dyalyz. - 2000 - 2, № 1-2. - S. 56-58.

Hygienic classification of pesticides by degree hazard / STATE STANDARDS 8.87.1.002. - K., 1998. - 181 p. 73 The original study

ISSN 2410-681X. Medical and clinical chemistry. 2016. T. 18. number 1

Huberuk VA lipid peroxidation and antioxidant defense system (review Literature) / VA Huberuk // Science. Visn. Lviv NUVMBT them. SZ Gzhytsky. - 2008 - 10, number 3 (38) h. 1. - P. 51-55.

Danchuk V. peroxidation in agriculture livestock and poultry / VV Danchuk. - Cam ' Kamyanets-Podolsky: ABC, 2006. - 192 p.

Horyachkovskyy A. Clinical biochemistry / AM Horyachkovskyy. - Odessa: Astroprint, 1998. - 608 p.

Amendment to the list of pesticides and agrochemicals approved for use in Ukraine / Ministry of Environmental Protection. - K., 2009. - 304 p.

Zavorotnaya RM oxygen at Synhletnыy Treatment rjada patolohycheskyh protsesov: physical and Chemical aspects / RM Zavorotnaya // Ukr. revmatol. Zh. - 2002. - № 1. - P. 35-37.

Scientific and practical advice maintenance laboratory animals and work with them / YM Kozhem ' Yakin, A. Khromov, MA Filonenko, GA Sayfetdinova. - K., Avicenna, 2002. - 156 p.

Kopytov TV Okyslytelnaya modyfykatsyya olyhopeptydov and proteins in chronic patients dermatoses s syndrome эndohennoy intoxication / TV Kopytov, O. Dmitrieva, LN // Hymkyna Funda-. study. - 2009. - № 6. - S. 25-29.

Lead ego and act in the organism (overview References) / AI Korbakova, NS Sorokin, N. Molodkyna [et al.] // Labor and Industrial Medicine ecology. - 2001. - № 5. - P. 29-34.

Korzhov VI Role of glutathione system in the process detoxification and antioxidant protection / VI Korzhov, VN Zhadan, MV Korzhov // J. Academy of Medical Sciences of Ukraine. - 2007 - 13, № 1. - S. 3-20.

Kuznetsova EM glyphosate, behavior in okruzhayuschey Levels ostatkov environment and / EM Kuznetsova, VD Chmyl // sovr. problems. Toxicological. - 2010. - № 1. - S. 87-95.

Lakyn GF Biometrics / ed. GF Lakyna. - Moscow: Higher School, 1990. - 352 p.

Mahynko VI Constants growth and funktsyonalnыe peryodы development in postnatal life belыh rat / VI Mahynko, VN Nikitin // Molekulyarnыe Mechanisms and fyzyolohycheskye vozrastnoho development. - K., 1975. - P. 308-326.

Effect of carnosine and N-acetyl ego proyzvodnoho red blood cells in patients stabylnost STATUS alcoholism in abstynentsyy / VD Prokopeva,

A. Bohan, P. Johnson, A. Boldyreva // Vopr. honey. chemistry. - 1998. - № 5. - P. 474-478.

Prokhorov MI biochemically Methods of research (Lipid exchange and power machinery): Textbook. posob. / Ed. MI Prohorovoy. - Leningrad: Izd Leningrad. University Press, 1982. - 272 p.

Old Man LI Antioxidant System: nature, composition, homeostasis mechanisms (literature review) / LI // Old Man of Science. Visn. Lviv NAVM them. SZ Gzhytsky. - 2007 - 9, number 3 (34), p. 2. - P. 172-177.

Frei B. Content of antioxidants, preformed lipid hydroperoxids and cholesterol as predictors of the susceptibility of human LDL to metalion-dependent and independent oxidation / B. Frei, J. M. Gaziano // J. Lipid

Res. - 1993. - 34 - R. 2135-2145.

Howard S. A. The relative effectiveness of human plasma glutathione peroxidase as a catalyst for the reduction of hydroperoxides by glutathione / S. A. Howard, W. C. Hawkes // Biol. Trace Element Res. 1998. - 61 - P. 127-136.

Downloads

Published

2016-05-12

How to Cite

Dmukhalska, Y. B., & Honsky, Y. I. (2016). THE INFLUENCE OF HEAVY METAL S, ORGANOPHOSPHATE PESTICIDES AND PEPTIDES ON THE ENZYME ACTIVITY OF GLUTATHIONE SYSTEM. Medical and Clinical Chemistry, (1), 70–74. https://doi.org/10.11603/mcch.2410-681X.2016.v0.i1.6187

Issue

Section

ORIGINAL INVESTIGATIONS