Сучасні погляди на біосинтез і механізм дії тиреоїдних гормонів
DOI:
https://doi.org/10.11603/mcch.2410-681X.2015.v17.i2.4879Анотація
З усіх відомих гормонів, що синтезуються в організмі, гормони щитоподібної залози проявляють
найширший спектр дії. Їх вплив спрямований не на певні органи-мішені, а поширюється на всі клітини
організму та субклітинні органели (ядра, мітохондрії, рибосоми, клітинні мембрани). Вони впливають
на експресію певних генів та здійснюють регуляцію швидкості обміну речовин. Захворювання, пов’язані з
функцією щитоподібної залози, належать до найбільш поширених у клінічній практиці ендокринних розладів,
що надає їм загальномедичного і соціального значення. У цьому огляді літератури наведено сучасні дані
досліджень механізмів регуляції функції щитоподібної залози, а також біосинтезу, секреції і механізмів дії
тиреоїдних гормонів.
Посилання
Activation and inactivation of thyroid hormone by
deiodinases: local action with general consequences /
B. Gereben, A. Zeöld, M. Dentice [et al.] // Cell Mol. Life
Sci. – 2008. – 65, № 4. – P. 570–590.
Alternate pathways of thyroid hormone metabolism
/ S. Y. Wu, W. L. Green, W. S. Huang [et al.] // Thyroid.
– 2005. – 15, № 8. – P. 943–958.
Cellular and molecular basis of deiodinaseregulated
thyroid hormone signaling / B. Gereben,
A. M. Zavacki, S. Ribich [et al.] // Endocr. Rev. – 2008. –
, № 7. – P. 898–938.
Cheng Sheue-Yann. Molecular Aspects of Thyroid
Hormone Actions / Cheng Sheue-Yann, L. Jack Leonard, J. Paul Davis // Endocr Rev. – 2010. – 31, № 2. –
P. 139–170.
Committee of the Clinical Society of London.
Report of a committee of the Clinical Society of London
nominated December 1883, to investigate the subject
of myxoedema // Trans. Clin. Soc. Lond. – 1883. – 21
Suppl. – P. 1888.
Coordinated regulation of transcription and alternative
splicing by the thyroid hormone receptor and
its associating coregulators / T. Satoh, A. Katano-Toki,
T. Tomaru [et al.] // Biochem. Biophys. Res. Commun. –
– 451, № 1. – P. 24–29.
CREB Binding Protein (CBP) Activation Is Required
for Luteinizing Hormone Beta Expression and
Normal Fertility in Mice / S. Ryan Miller, Andrew Wolfe,
Ling He [et al.] // Mol Cell Biol. – 2012. – 32, № 13. –
P. 2349–2358.
Crystal structure of iodotyrosine deiodinase,
a novel flavoprotein responsible for iodide salvage
in thyroid glands / S. R. Thomas, P. M. McTamney,
J. M. Adler [et al.] // Biol. Chem. – 2009. – 284, № 29. –
P. 19659–19667.
Decreased Expression of Thyroglobulin and Sodium
Iodide Symporter Genes in Hashimoto’s Thyroiditis /
A. Popławska-Kita, B. Telejko, K. Siewko [et al.] // Int. J.
Endocrinol. – 2014. – P. 690–704.
Effects of Clofibrate on Salt Loading-Induced
Hypertension in Rats / Antonio Cruz, Isabel Rodríguez-
Gómez, Rocío Pérez-Abud, Miguel Ángel Vargas // J.
Biomed. Biotechnol. – 2011. – P. 469–481.
Effects of iodothyronines on the hepatic outer-ring
deiodinating pathway in killifish / G. C. Garcia, M. C. Jeziorski,
R. C. Valverde [et al.] // General and Comparative
Endocrinology. – 2004. – 135. – P. 201–209.
European thyroid association guidelines for the
management of familial and persistent sporadic non-autoimmune
hyperthyroidism caused by thyroid-stimulating
hormone receptor germline mutations / R. Paschke,
M. Niedziela, B. Vaidya [et al.] // J. Eur. Thyroid. J. –
– 1, № 3. – P. 142–147.
Evidence for site-specific occupancy of the
mitochondrial genome by nuclear transcription factors /
G. K. Marinov, Y. E. Wang, D. Chan, B. J. Wold // PLoS
One. – 2014. – 9, № 1. – P. 84713.
Expression, purification and preliminary crystallographic
analysis of human thyroid hormone responsive
protein / Wenzheng Zhang, Wei Peng, Mingzhuo Zhao
[et al.] // Acta Crystallogr. Sect. F. Struct. Biol. Cryst.
Commun. – 2011. – 67, № 8. – P. 941–946.
Grani G. Thyroglobulin in Lymph Node Fine-
Needle Aspiration Washout: A Systematic Review
and Meta-analysis of Diagnostic Accuracy / G. Grani,
A. Fumarola // The Journal of clinical endocrinology and
metabolism. – 2014. – 99, № 6. – P. 1970–1982.
Gross J. Triiodothyronine in relation to thyroid
physiology / J. Gross, R. Pitt-Rivers // Rec. Prog. Horm.
Res. – 1959. – 10. – P. 109–128.
Haack Karla K. V. NF-κB and CREB Are Required
for Angiotensin II Type 1 Receptor Upregulation in Neurons
/ Karla K. V. Haack, Amit K. Mitra, Irving H. Zucker //
PLoS One. – 2013. – 8, № 11. – P. 786–795.
Heuer H. Minireview: Pathophysiological importance
of thyroid hormone transporters / H. Heuer, T. J. Visser
// Endocrinology. – 2009. – 150. – P. 1078.
Hyperthyroidism and human chorionic gonadotrophin
production in gestational trophoblastic disease /
L. Walkington, J. Webster, B. W. Hancock [et al.] // Br. J.
Cancer. – 2011. – 104, № 11. – P. 1665–1669.
Hypothalamic effects of thyroid hormones
on metabolism / N. Martínez-Sánchez, C. V. Alvarez,
J. Fernø [et al.] // Best Pract. Res. Clin. Endocrinol.
Metab. – 2014. – 28, № 5. – P. 703–712.
Iodine deficiency in 2007: global progress since
/ B. de Benoist, E. McLean, M. Andersson [et al.] //
Food Nutr Bull. – 2008. – 29, № 3. – P. 195–202.
Kendall E. C. The isolation in crystalline form
of the compound containing iodine which occurs in the
thyroid: its chemical nature and physiological activity /
E. C. Kendall // Trans. Assoc. Am. Physicians. – 1915. –
– P. 420–449.
Khandelwal D. Overt and subclinical hypothyroidism:
who to treat and how / D. Khandelwal,
N. Tandon // Drugs. – 2012. – 72, № 1. – P. 17–33.
Ligand binding shifts highly mobile retinoid X
receptor to the chromatin-bound state in a coactivatordependent
manner, as revealed by single-cell imaging /
P. Brazda, J. Krieger, B. Daniel [et al.] // Mol. Cell Biol. –
– 34, № 7. – P. 1234–1245.
Mitochondrial calcium uniporter MCU supports
cytoplasmic Ca2+ oscillations, store-operated Ca2+ entry
and Ca2+-dependent gene expression in response
to receptor stimulation / K. Samanta, S. Douglas,
A. B. Parekh [et al.] // PLoS. One. – 2014. – 9, № 7. –
P. 101–188.
Molecular and genetic studies suggest that
thyroid hormone receptor is both necessary and sufficient
to mediate the developmental effects of thyroid hormone /
B. Das, H. Matsuda, K. Fujimoto [et al.] // Gen. Comp.
Endocrinol. – 2010. – 168, № 2. – P. 174–180.
Molecular mechanisms of corticosteroid synergy
with thyroid hormone during tadpole metamorphosis /
Ronald M. Bonett, Eric D. Hoopfer, Robert J. Denver
[et al.] // Gen. Comp. Endocrinol. – 2010. – 168, № 2. –
P. 209–219.
Non-classic thyroid hormone signalling involved
in hepatic lipid metabolism / A. Cordeiro, L. L. Souza,
M. Einicker-Lamas [et al.] // J. Endocrinol. – 2013. – 216,
№ 3. – P. 47–57.
Paul Yen M. Physiological and Molecular Basis
of Thyroid Hormone Action / M. Paul Yen // Physiological
Reviews. – 2001. – 81, № 3. – Р. 1097–1142.
Physiopathological aspects of the subclinical
alterations of thyroid function associated with acute
coronary syndromes / C. S. Stamate, A. M. Andronescu,
A. C. Nechita [et al.] // J. Med. Life. – 2013. – 6, № 4. –
P. 409–413.
Pitting type of pretibial edema in a patient with
silent thyroiditis successfully treated by angiotensin
ii receptor blockade / I. Kazama, Y. Mori, A. Baba,
T. Nakajima // Am. J. Case. Rep. – 2014. – 15. – P. 111– 114.
Pituitary-thyroid setpoint and thyrotropin receptor
expression in consomic rats / L. C. Moeller, M. Alonso,
X. Liao [et al.] // Endocrinology. – 2007. – 148, № 10. –
P. 4727–4733.
Plasma membrane transport of thyroid hormones
and its role in thyroid hormone metabolism and
bioavailability / G. Hennemann, R. Docter, E. C. Friesema
[et al.] // Endocr. Rev. – 2001. – 22, № 4. – Р. З451–
Saaresranta T. Hormones and breathing /
T. Saaresranta, O. Polo // Chest. – 2002. – 122, № 6. –
Р. 2165–2182.
Selective estrogen receptor modulators: tissue
specificity and clinical utility / S. Martinkovich, D. Shah,
S. L. Planey [et al.] // Clin. Interv. Aging. – 2014. – 28,
№ 9. – P. 1437–1452.36. Simonides W. S. Hypoxia-inducible factor
induces local thyroid hormone inactivation during
hypoxic-ischemic disease in rats / W. S. Simonides,
M. A. Mulcahey, E. M. Redout // J. Clin. Invest. – 2008. –
, № 3. – P. 975–983.
Stable isotope labeling with amino acids in cell
culture (SILAC)-based quantitative proteomics study
of a thyroid hormone-regulated secretome in human
hepatoma cells / C. Y. Chen, L. M. Chi, H. C. Chi [et al.] //
Mol. Cell Proteomics. – 2012. – 11, № 4. – P. 111–127.
Tao Y. X. Constitutive activation of G proteincoupled
receptors and diseases: insights into mechanisms
of activation and therapeutics / Y. X. Tao // Pharmacol.
Ther. – 2008. – 120, № 2. – P. 129–148.
Tata J. R. Ribonucleic acid synthesis during the
early action of thyroid hormones / J. R. Tata, C. C. Widnell //
Biochem. J. – 1966. – 98. – P. 604–629.
The c-erbA protein is a high affinity receptor for
thyroid hormone / B. Vennstrom, J. Sap, A. Munoz [et al.] //
Nature. – 1986. – 324. – P. 635–640.
The Trifunctional Protein Mediates Thyroid
Hormone Receptor-Dependent Stimulation of Mitochondria
Metabolism / Sandra Chocron, Naomi L. Sayre, Deborah
Holstein [et al.] // Mol. Endocrinol. – 2012. – 26, № 7. –
P. 1117–1128.
Thyroid function during critical illness / F. Economidou,
E. Douka, M. Tzanela [et al.] // Hormones
(Athens). – 2011. – 10, № 2. – P. 117–124.
Thyroid hormones and thyroid hormone
receptors: effects of thyromimetics on reverse cholesterol
transport / M. Pedrelli, C. Pramfalk, P. Parini [et al.] //
Gastroenterol. – 2010. – 16, № 47. – P. 5958–5964.
Thyroid stimulating hormone levels rise after
assisted reproductive technology / S. Reinblatt, B. Herrero,
J. A. Correa [et al.] // J. Assist. Reprod. Genet. – 2013. –
, № 10. – P. 1347–1352.
