Modern views on the biosynthesis and mechanism of action of thyroid hormones
DOI:
https://doi.org/10.11603/mcch.2410-681X.2015.v17.i2.4879Abstract
Among all hormones, which are synthesized in the human body, thyroid hormones have the widest spectrum of
activity. Their effect is not directed at specific target organs but applies to all body's cells and subcellular organelles
(nucleus, mitochondria, ribosomes, cell membranes). They affect the expression of certain genes and regulation
of metabolic rate. Diseases associated with thyroid function are among the most common in clinical practice of
endocrine disorders. At this review the modern data of studies of thyroid function mechanisms regulation, as well
as biosynthesis, secretion and the mechanisms of action of thyroid hormones are shown.
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