CHANGES IN INDICATORS OF THE LIPID PROFILE AND ADIPOKINES DEPENDING ON A1166C-GENE POLYMORPHISM OF ANGITENSIN II TYPE I AS A PREDICTOR OF THE DEVELOPMENT OF ARTERIAL HYPERTENSION
DOI:
https://doi.org/10.11603/mcch.2410-681X.2023.i4.14377Keywords:
gene polymorphism, arterial hypertension, dyslipidemiaAbstract
Introduction. As evidenced by the results of research in recent years, genetic factors play an important role in the development and course of arterial hypertension. The study of the renin-angiotensin-aldosterone system gene polymorphism is a promising direction for assessing the relationship between heredity, arterial hypertension and dyslipidemia.
The aim of the study – to investigate the parameters of the lipid profile and adipokines depending on the polymorphism A1166C of the angiotensin II receptor type 1 gene as a predictor of the development of arterial hypertension.
Research Methods. 86 patients with arterial hypertension took part in the study. The control group consisted of 30 practically healthy people. Indicators of lipid metabolism in the blood serum of the studied patients were determined with the help of “Lachema” kits on the analyzer. The study of the allelic polymorphism A1166C of the angiotensin II receptor gene of the first type was carried out by the method of polymerase chain reaction with electrophoretic detection of the results.
Results and Discussion. The level of total cholesterol when replacing carriers of the CC genotype turned out to be significantly higher by 49.9 % compared to carriers of the AA genotype. The indicators of LDL and VLDL in carriers of the CC genotype were 1.4 and 3.2 times higher than in homozygotes for the A allele. The content of triglycerides in blood serum was significantly 2.48 times higher in carriers of the CC genotype than in patients with the AA genotype. HDL values are lower in homozygotes for the C allele in patients with the AA genotype by 60.4 %. Carriers of the CC genotype are characterized by significantly higher levels of resistin, leptin, and adiponectin compared to carriers of the AA genotype, but the level of ghrelin is lower in carriers of the CC genotype.
Conclusions. The presence of the CC genotype of the angiotensin II type 1 receptor gene contributes to the development of dyslipidemia. In patients with arterial hypertension, the presence of the C allele of the angiotensin II type 1 gene contributes to a significant increase in serum adipokines and a decrease in the level of ghrelin.
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