EFFECTS OF BIOLOGICAL ACTION OF MOLECULAR HYDROGEN
DOI:
https://doi.org/10.11603/mcch.2410-681X.2023.i2.13980Keywords:
molecular hydrogen, hydrogen water, oxidative stress, cancer, antioxidantsAbstract
Introduction. The article presents a review of the scientific literature on the effect of molecular hydrogen depending on the ways of introduction on different levels of the body's organization in various pathological conditions. The history of the discovery of molecular hydrogen as a biological agent and the development of hydrogen biomedicine is briefly presented. The molecular, cellular and systemic aspects of the biological action of molecular hydrogen are characterized. The effect of molecular hydrogen on various cell pools and regeneration processes, antioxidant and antiapoptotic effects of molecular hydrogen are revealed. The anti-inflammatory effect and regulation of pyroptosis by molecular hydrogen are described. In this article, the information was analyzed using PubMed, PubChem, ScienceDirect, European Pharmacopoeia and scientific literature databases.
The aim of the study – to analyze the scientific literature and systematize information about the nature of molecular hydrogen and its ways of entry into the body, as well as about the features and mechanisms of molecular, cellular, organ-tissue and systemic biological effects of molecular hydrogen.
Conclusions. Molecular hydrogen is the lightest and most common medical gas, which has a wide range of biological activity and is characterized by antioxidant, anti-inflammatory and anti-apoptotic effects. It is also involved in regulating the expression of numerous genes, protecting biomacromolecules from oxidative damage, stimulating energy production (ATP), etc. At the same time, despite the sharp increase in the number of studies and publications on the biomedical application of molecular hydrogen, the issue of its use as a pro-regenerative agent requires additional study. The use of this molecule has numerous advantages due to the wide range of molecular reactions it induces. Therefore, targeted research in this field can open new horizons of regenerative medicine and create innovative technology for accelerated body recovery.
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