THE CONTENT OF INTERLEUKIN-1β, PROCALCITONIN IN THE SERUM OF PATIENTS WITH LACTATIONAL MASTITIS

Authors

  • N. R. Demianchuk DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY
  • V. M. Akimova DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY
  • М. М. Shchurko DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY
  • N. Z. Lutsiv DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY
  • L. D. Soyka DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY
  • B. M. Beliavska DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY
  • L. Y. Lapovets DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY
  • O. Y. Buchko DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY
  • S. O. Tkachuk DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY

DOI:

https://doi.org/10.11603/mcch.2410-681X.2023.i2.13972

Keywords:

interleukin-1β, procalcitonin, lactostasis, lactational mastitis

Abstract

Introduction.  Favorable factors for the development of the inflammatory process in the mammary gland are lactostasis, the presence of pathogenic flora, as well as a decrease in the immunobiological reactivity of the woman’s body. The inflammatory process is driven and regulated by a number of mediators. In particular, pro-inflammatory interleukin-1β induces an inflammatory reaction and an acute phase response, and carries out the interaction between nonspecific and specific links of immunity. Procalcitonin is considered the most promising indicator of the septic process, which allows for a differential diagnosis of bacterial and non-bacterial inflammation, for assessing the severity of the patient's condition and the effectiveness of anti-inflammatory therapy.

The aim of the study – to assess the content of interleukin-1β, procalcitonin in the serum of patients with lactational mastitis.

Research Methods. The blood serum of 97 women aged 18 to 36 have been examined (average age: 26±5 years old). The control group consisted of 30 practically healthy lactating women, the first group included 30 women with lactostasis, the second group – 37 women who developed lactational mastitis. The contents of interleukin-1β and procalcitonin were determined by enzyme immunoassay using an automatic STAT FAX 303 plus analyzer.

Results and Discussion. The content of IL-1β in the serum of women of group I ((6.37±0.46) pg/ml) is 3.5 times higher than that of the control group ((1.78±0.11) pg/ml, p<0.05). The average concentration of IL-1β in group II is (8.32±0.38) pg/ml, which is 4.7 times higher than the control values and exceeds the indicator of women in group I by 1.3 times (p<0.05). With the development of lactostasis, the PCT content ((0.07±0.02) ng/ml) is 3.3 times higher than the control value ((0.021±0.004) ng/ml, p<0.05). In the serum of women of group II, the PCT content is (0.81±0.25) ng/ml, which exceeds the value of this marker in the control group and group I by 38.6 and 11.6 times, respectively (p<0.05).

Conclusions. The established concentration of IL-1β confirms the role of this cytokine in the protective reaction and can be used to assess the activity of the inflammatory process in lactostasis and lactational mastitis. Determining procalcitonin as a marker of bacterial infection is appropriate for the prognosis of the septic process in the mammary gland.

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Published

2023-07-11

How to Cite

Demianchuk, N. R., Akimova, V. M., Shchurko М. М., Lutsiv, N. Z., Soyka, L. D., Beliavska, B. M., … Tkachuk, S. O. (2023). THE CONTENT OF INTERLEUKIN-1β, PROCALCITONIN IN THE SERUM OF PATIENTS WITH LACTATIONAL MASTITIS. Medical and Clinical Chemistry, (2), 51–55. https://doi.org/10.11603/mcch.2410-681X.2023.i2.13972

Issue

No. 2 (2023)

Section

ORIGINAL INVESTIGATIONS

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