INFLUENCE OF GLYCEMIA LEVELS IN PATIENTS WITH DIABETES ON THE STATUS OF THE MICROBIOME OF DIFFERENT BIOTOPES
Keywords:glycated hemoglobin, diabetes, microbiota
Introduction. The incidence of diabetes mellitus, which is steadily increasing in the human population, and the complications that occur in such patients, caused by representatives of the autochthonous microflora, prompt the study of the reasons that contribute to such processes, in particular, the influence of glycated hemoglobin levels and changes in the pathogenic properties of microorganisms in patients with diabetes.
The aim of the study – to investigate literature data on changes in the structure and properties of the microbiome of certain biotopes, patients with diabetes, and to find out the influence of glycated hemoglobin levels on the properties of representatives of the microflora.
Research Methods. To carry out this review, we analyzed articles published in scientific journals. For the search, we used databases of leading foreign publications. Those articles containing information about the course of diabetes and the state of the microbiome of certain areas were chosen as the selection criteria.
Results and Discussion. The review presents and analyzes the results of domestic and foreign research, with references to primary sources, on changes in the structure and certain properties of microorganisms – representatives of the autochthonous microflora of the oral cavity, stomach, intestines, conjunctiva, the frequency of detection of pathogenic and conditionally pathogenic microorganisms in the above biotopes. Their impact on glucose metabolism, the impact of glycemic levels on biodiversity and virulence properties of microbiota, in particular S. aureus, Helicobacter pylori, Staphylococcus epidermidis and others, changes in the ratio of aerobic and anaerobic intestinal microbiota in patients with diabetes and when it is combined with other nosological forms and in experimental conditions.
Conclusions. Summarizing the results of the studied literature data, it can be stated that the level of glycated hemoglobin directly or indirectly affects the frequency of bacterial complications in patients with DM, namely by increasing the virulence properties of representatives of the normal flora of different biotopes, increasing the colonization of specific areas of the mucous membranes or skin by a certain microbe, and disrupting the relationship between different representatives of a separate biotope.
Tsitovsky, M.N. (2017). Statistical, clinical and morphological aspects of the influence of diabetes on the state of the cardiovascular system. Scientific Bulletin of Uzhhorod University., 1 (55), 168-177.
Lindblom, R., Ververis, K., Tortorella, SM., Karagiannis, T.C. (2015). The early life origin theory in the development of cardiovascular disease and type 2 diabetes. Molecular Biology Reports., 42 (4): 791-797. Epub 2014/10/02. pmid:25270249.
Walker, A.W. (2011). Dominant and diet-responsive groups of bacteria within the human colonic microbiota. ISME J., 5, 220-230.
Bengmark, S. (2012). Gut microbiota, immune development and function. Pharmacol. Res., 7, 1023-1029.
Cunningham-Rundles, S., Ahrne, S., JohannLiang, R. (2011). Effect of probiotic bacteria on microbial host defense, growth, and immune function in human immunodeficiency virus type-1 infection. Nutrients, 3, 1042-1070.
Tap, J., Mondot, S., Levenez, F., Pelletier, E., Caron, C. et al. (2009). Towards the human intestinal microbiota phylogenetic core. Environ Microbiol., 11, 2574-2584.
Shim, E., Babu, J.P. (2015). Glycated albumin produced in diabetic hyperglycemia promotes monocyte secretion of inflammatory cytokines and bacterial adherence to epithelial cells. J. Periodontal. Res., 50, 197-204
Han, X., Li ,Y., Wang, J., Liu, B., Hu, H., Li , X., et al. (2016). Helicobacter pylori infection is associated with type 2 diabetes among a middle- and old-age Chinese population. Diabetes Metab. Res. Rev., 32, 95-101. DOI: 10.1002/dmrr.2677
Louis, P., Young, P., Holtrop, G., Flint, H.J . (2010). Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-CoA:acetate CoA transferase gene. Environ. Microbiol., 12, 304-331.
Maluf, S., Salgado, J.V., Cysne, D.N., Camelo, D.M.F., Nascimento, J.R. et al. (2020). Increased glycated hemoglobin levels in patients with Helicobacter pylori infection are associated with the grading of chronic gastritis. Front. Immunol., DOI: 10.3389/fimmu.2020.02121
Htun, NSN., Odermatt, P., Müller, I., Yap, P., Steinmann, P., Schindler, C. et al. (2018). Association between gastrointestinal tract infections and glycated hemoglobin in school children of poor neighborhoods in Port Elizabeth, South Africa. PLoS Negl. Trop. Dis., 12, e0006332. DOI: 10.1371/journal.pntd.0006332
Horikawa, C., Kodama, S., Fujihara, K., Yachi, Y., Tanaka, S., Suzuki, A. et al. (2014). Association of Helicobacter pylori infection with glycemic control in patients with diabetes: a meta-analysis. J. Diabetes Res., 2014, 50620. DOI: 10.1155/2014/250620
Chen, Y., Blaser, M.J. (2012). Association between gastric Helicobacter pylori colonization and glycated hemoglobin levels. J. Infect. Dis., 205, 1195-202. DOI: 10.1093/infdis/jis106
Weyer, C., Hanson, R.L., Tataranni, P.A., Bogardus, C., Pratley, R.E. (2000). A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia. Diabetes, 49:2094–101. DOI: 10.2337/diabetes.49.12.2094
Acharya, A.B., Thakur, S., Muddapur, M.V. (2015). Evaluation of serum interleukin-10 levels as a predictor of glycemic alteration in chronic periodontitis and type 2 diabetes mellitus. J. Indian Soc. Periodontol., 19, 388-392. DOI: 10.4103/0972-124X.150876
Moreno, N.P., Moreno, R.D., Sousa, L. B. (2014). Aerobic bacterial microbiota of the conjunctiva in diabetic patients with normal and altered glycated hemoglobin levels in two regions in Brazil. Arq. Bras. Oftalmol., 77 (6), 351-354. ISSN 0004-2749. https://doi.org/10.5935/ 0004-2749.20140088.
Hays, R., Esterman, A., Giacomin, P., Loukas, A., McDermott, R. (2015). Does Strongyloides stercoralis infection protect against type 2 diabetes in humans? Evidence from Australian Aboriginal adults. Diabetes Research and Clinical Practice., 107 (3), 355-361. Epub 2015/02/07. pmid:25656764.
World Health Organization. Preventive chemotherapy in human helminthiasis Geneva, Switzerland; 2006.
Howard, B.V., Best, L., Comuzzie, A. (2008). C-reactive protein, insulin resistance, and metabolic syndrome in a population with a high burden of subclinical infection: insights from the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study. Diabetes Care , 31, 2312-2314.
Demmer, R.T., Jacobs, DR.Jr., Desvarieux, M.(2008). Periodontal disease and incident type 2 diabetes: results from the First National Health and Nutrition Examination Survey and its epidemiologic follow-up study. Diabetes Care, 31, 1373-1379
Grellmann, A.P., Sfreddo, C.S., Maier, J., Lenzi, T.L., Zanatta, F.B. (2016). Systemic antimicrobials adjuvant to periodontal therapy in diabetic subjects: a meta-analysis. J. Clin. Periodontol., 43, 250-260
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