FEATURES OF LIPOPEROXIDATION PROCESSES IN THE PROSTATE AT CHRONIC ALCOHOL INTOXICATION
Keywords:prostate, lipoperoxidation, chronic alcohol intoxication
Introduction. Chronic alcohol intoxication leads to damage to almost all organs and systems, the degree of structural and functional disorders of which in this pathology is different and depends on the duration and severity of intoxication.
The aim of the study – to learn the features of lipoperoxidation processes in the prostate gland during chronic alcohol intoxication.
Research Methods. Biochemical and morphometric methods investigated the structures of the prostate of 60 laboratory adult white male rats, which were divided into 2 groups. Group 1 included 30 intact experimental animals, group 2 included 30 rats that were at chronic alcohol intoxication. A month after the start of the experiment, the experimental animals were euthanized by bloodletting under thiopental anesthesia. The content of diene conjugates, active products of thiobarbituric acid, was determined in prostate homogenates. Correlation analysis was carried out between biochemical and studied histostereometric parameters with determination of correlation coefficient (r). Quantitative indicators were processed statistically.
Results and Discussion. It was established that in conditions of chronic ethanol intoxication, the processes of lipoperoxidation in the tissues of the prostate significantly increase. The level of diene conjugates increased by 2.3 times (p<0.001), the concentration of active products of thiobarbituric acid by 2.4 times (p<0.001). Stromal-parenchymatous relation in chronic ethanol intoxication in the studied organ increased by 1.57 times, nuclear-cytoplasmic ratios in endotheliocytes – by 7.6 %, epitheliocytes of glands – by 9.6 % (р<0.001), the relative volume of damaged endotheliocytes – 11.66 times, gland epitheliocytes – 19.7 times (p<0.001). Strong positive correlations between biochemical and morphometric indicators were revealed.
Conclusions. Chronic alcohol intoxication leads to a marked increase in peroxide oxidation of lipids in prostate tissues and damage to the endotheliocytes of arteries and epithelial cells of glands, infiltrative and sclerotic processes. The degree of lipoperoxydation disorders in simulated pathology correlates with the severity of changes in structural homeostasis, the relative volumes of damaged endotheliocytes, glandular epitheliocytes, and stromal-parenchymal relations in the organ under study.
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