FEATURES OF THE STRUCTURAL AND FUNCTIONAL CONDITION OF THE MYOCARDIUM DEPENDING ON ST2 AND TROPONINE I PLASMA LEVELS IN NSTEMI PATIENTS
DOI:
https://doi.org/10.11603/mcch.2410-681X.2022.i1.12678Keywords:
NSTEMI, ST2, troponin I, structural remodelingAbstract
Introduction. The prevalence of myocardial infarction without ST-segment elevation and the risk of adverse events in the long term encourage the search for and study of non-invasive predictors of destabilization of the disease. ST2 is considered as one of such markers.
The aim of the study – to determine the features of the structural and functional condition of the myocardium depending on the levels of ST2 and troponin I in plasma in patients with NSTEMI.
Research Methods. The study involved 200 patients with NSTEMI aged 38 to 80 years. All patients were examined according to the current treatment protocol for patients with acute myocardial infarction without ST segment elevation, plasma levels of ST2 and troponin I were determined.
Results and Discussion. The dependence of ST2 level and the absence of such for troponin I level in plasma with the value of the left ventricular myocardial mass index was established. The results of the analysis show that the value of the left ventricular myocardial mass index >115 g/m2 in patients with NSTEMI is associated with a higher level of ST2 in plasma (median – 43.7 ng/ml). Analysis of the level of ST2 and troponin I in plasma in NSTEMI patients depending on the value of the relative myocardial wall thickness showed no statistically significant dependence of factors on its value. However, there was a tendency in the frequency of registration of cases of relative myocardial wall thickness of different sizes in the case of associations of relatively high levels of ST2 and troponin I. The data show that in the case of relatively high levels of ST2 parallel change in plasma with different values of the relative myocardial wall thickness.
Conclusions. ST2 levels, regardless of troponin I levels, are associated with an increase in left ventricular myocardial mass index as opposed to relative myocardial wall thickness. Determination of elevated ST2 levels in the early period tends to electrical instability of the myocardium, which requires appropriate preventive measures in this category of patients.
References
Richardson, W.J., Clarke, S.A., Quinn, T.A., & Holmes, J.W. (2015). Physiological implications of myocardial scar structure. Compr. Physiol., 5 (4), 1877-1909. DOI: 10.1002/cphy.c140067.
Shrivastava, A., Haase, T., Zeller, T., & Schulte, C. (2020). Biomarkers for heart failure prognosis: proteins, genetic scores and non-coding RNAs. Front. Cardiovasc. Med., 7, 601364. DOI: 10.3389/fcvm.2020.601364.
Collet, J.P., Thiele, H., Barbato, E., Barthélémy, O., Bauersachs, J., Bhatt, D.L., …, & Sibbing, D. (2021). 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur. Heart J., 42 (14), 1289-1367. DOI: 10.1093/eurheartj/ehaa575.
Mueller, T., & Dieplinger, B. (2013). The Presage®ST2 Assay: analytical considerations and clinical applications for a high-sensitivity assay for measurement of soluble ST2. Expert Rev. Mol. Diagn., 13, (1), 13-30. DOI: 10.1586/erm.12.128.
Mezhiievska, I., Ivanov, V., & Maslovskyi, V. (2020). ST2 plasma level in patients with acute myocardial infarction without st elevation and different clinical characteristics. EUREKA: Health Sci., 1, 47-54. DOI: 10.21303/2504-5679.2020.001098.
Kercheva, M., Ryabova, T., Gusakova, A., Suslova, T.E., Ryabov, V., & Karpov, R.S. (2019). Serum soluble ST2 and adverse left ventricular remodeling in patients with ST-Segment elevation myocardial infarction. Clin. Med. Insights Cardiol., 13, 1179546819842804. DOI: 10.1177/1179546819842804.
Monteiro, L.M., Vasques-Nóvoa, F., Ferreira, L., Pinto-do-Ó, P., & Nascimento, D.S. (2017). Restoring heart function and electrical integrity: closing the circuit. NPJ Regen. Med., 2, 9. DOI: 10.1038/s41536-017-0015-2.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Medical and Clinical Chemistry
This work is licensed under a Creative Commons Attribution 4.0 International License.
