CLINICAL AND LABORATORY CHARACTERISTICS OF COMORBID COURSE TYPE 2 DIABETES MELLITUS WITH OVERWEIGHT/OBESITY AND ARTERIAL HYPERTENSION
Keywords:type 2 diabetes mellitus
Introduction. Arterial hypertension (AH) is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM), which is associated with cardiovascular disease.
The aim of the study – to analyze the main clinical and laboratory factors of comorbid type 2 diabetes mellitus with overweight/obesity and hypertension.
Research Methods. A retrospective analysis of medical records was performed in 579 patients with type 2 diabetes mellitus (T2DM). The concentration of glucose and other biochemical parameters were determined using a standard kit on an automatic biochemical analyzer "COBAS INTEGRA® 400" (Roche Diagnostics). General blood counts were determined on an automatic hematology analyzer "Yumizen H500 CT".
Results and Discussion. The analysis of Kraskel-Wallis rank variations did not reveal the diagnostic value of general blood and urine tests in the diagnosis of comorbid course of diabetes mellitus, overweight/obesity and hypertension. The analysis of biochemical parameters revealed the highest levels of urea and uric acid in patients with diabetes mellitus, obesity and hypertension. Analysis of carbohydrate metabolism showed that the level of glucose, insulin and HOMA-index in the blood of patients from different experimental groups probably differed when analyzing the rank variations of Kraskel-Wallis.
Conclusions. The analysis of sexual dimorphism revealed a predominance of females with comorbid type 2 diabetes, overweight/obesity and hypertension. At the same time, among patients with type 2 diabetes mellitus with comorbid arterial hypertension, a significantly higher percentage of sick men with normal body weight was found. In the analysis of anthropometric parameters of patients of different groups, it was found that in patients of group 6 the growth was probably lower than in patients with T2DM with normal body weight and in combination with AH. BMI was likely to be higher in overweight/obese patients. Patients with comorbid type 2 diabetes, overweight/obesity, and arterial hypertension had significantly higher levels of urea (24.4 %) and uric acid (93.0 %) compared to patients with diabetes mellitus type 2 and normal body weight.
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