TYPE 2 DIABETES MELLITUS AND HYPOTHYROIDISM: LABORATORY DATA
Keywords:type 2 diabetes mellitus, hypothyroidism, laboratory data
Introduction. Hypothyroidism is more common in patients with type 2 diabetes than in the general population. These are the two most common endocrine disorders in the world. Comorbidity of type 2 diabetes and hypothyroidism will worsen macro-vascular complications, quality of life and mortality. More and more scientists recommend routine determination of thyroid hormone levels in patients with type 2 diabetes, which will help better control these two conditions.
The aim of the study – to evaluate laboratory parameters in patients with combined course of type 2 diabetes mellitus and hypothyroidism and to identify possible markers of their comorbid course.
Research Methods. A retrospective study of medical records of 538 patients with type 2 diabetes who were treated at the Endocrine Department of Ternopil University Hospital in 2019. Two experimental groups were formed: group 1 (501 patients with type 2 diabetes mellitus (T2DM)) and group 2 (37 patients with comorbid T2DM and hypothyroidism). Laboratory data were evaluated (results of general blood analysis, lipidograms, thyroid hormones, biochemical markers). Statistical analysis was performed by calculating the median (Me), lower (Lq) and upper (Uq) quartiles, Mann-Whitney U-test.
Results and Discussion. The study of general blood tests revealed probably lower Hb and RBC in group 2 (p=<0.001 and p=0.043), the level of ESR was 15.4 % higher than in group 1 (p=0.045). HbA1c values were 10.0 % higher in group 2 (p=0.035) compared with group 1. Evaluating the lipid profile revealed significantly differences in HDL-C, RC, non-HDL-C and TG between experimental groups (p=0.01, p=0.004, p=0.008, p=0.047).
Conclusions. Patients with comorbid type 2 diabetes mellitus and hypothyroidism have significantly lower values of hemoglobin and erythrocytes, significantly higher levels of ESR, HbA1c, and progressing dyslipidemia due to HDL-C, RC, non-HDL-C and TG compered to patients with type 2 diabetes mellitus only.
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