type 2 diabetes mellitus, hypothyroidism, laboratory data


Introduction. Hypothyroidism is more common in patients with type 2 diabetes than in the general population. These are the two most common endocrine disorders in the world. Comorbidity of type 2 diabetes and hypothyroidism will worsen macro-vascular complications, quality of life and mortality. More and more scientists recommend routine determination of thyroid hormone levels in patients with type 2 diabetes, which will help better control these two conditions.

The aim of the study – to evaluate laboratory parameters in patients with combined course of type 2 diabetes mellitus and hypothyroidism and to identify possible markers of their comorbid course.

Research Methods. A retrospective study of medical records of 538 patients with type 2 diabetes who were treated at the Endocrine Department of Ternopil University Hospital in 2019. Two experimental groups were formed: group 1 (501 patients with type 2 diabetes mellitus (T2DM)) and group 2 (37 patients with comorbid T2DM and hypothyroidism). Laboratory data were evaluated (results of general blood analysis, lipidograms, thyroid hormones, biochemical markers). Statistical analysis was performed by calculating the median (Me), lower (Lq) and upper (Uq) quartiles, Mann-Whitney U-test.

Results and Discussion. The study of general blood tests revealed probably lower Hb and RBC in group 2 (p=<0.001 and p=0.043), the level of ESR was 15.4 % higher than in group 1 (p=0.045). HbA1c values ​​were 10.0 % higher in group 2 (p=0.035) compared with group 1. Evaluating the lipid profile revealed significantly differences in HDL-C, RC, non-HDL-C and TG between experimental groups (p=0.01, p=0.004, p=0.008, p=0.047).

Conclusions. Patients with comorbid type 2 diabetes mellitus and hypothyroidism have significantly lower values ​​of hemoglobin and erythrocytes, significantly higher levels of ESR, HbA1c, and progressing dyslipidemia due to HDL-C, RC, non-HDL-C and TG compered to patients with type 2 diabetes mellitus only.


Cho, N.H., Shaw, J.E., Karuranga, S., Huang, Y., da Rocha Fernandes, J.D., Ohlrogge, A.W., & Malanda, B. (2018). IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res. Clin. Pract., 138, 271-281. DOI:10.1016/j.diabres.2018.02.023

Mahdavi, M., Amouzegar, A., Mehran, L., Madreseh, E., Tohidi, M., & Azizi, F. (2021). Investigating the prevalence of primary thyroid dysfunction in obese and overweight individuals: Tehran thyroid study. BMC Endocr. Disord., 21 (1), 89. DOI:10.1186/s12902-021-00743-4

Ogbonna, S.U., & Ezeani, I.U. (2019). Risk factors of thyroid dysfunction in patients with type 2 diabetes mellitus. Front Endocrinol. (Lausanne), 10, 440. DOI:10.3389/fendo.2019.00440

Diab, N., Daya, N.R., Juraschek, S.P., Martin, S.S., McEvoy, J.W., Schultheiss, U.T., . . . Selvin, E. (2019). Prevalence and risk factors of thyroid dysfunction in older adults in the community. Sci. Rep., 9 (1), 13156. DOI:10.1038/s41598-019-49540-z

Elmenshawi, I.M. (2017). Prevalence of thyroid dysfunction in diabetic patients. Journal of Diabetes, Metabolic Disorders & Control, 4 (2). DOI:10.15406/jdmdc.2017.04.00106

Jali, M.V., Kambar, S., Jali, S.M., Pawar, N., & Nalawade, P. (2017). Prevalence of thyroid dysfunction among type 2 diabetes mellitus patients. Diabetes Metab. Syndr., 11 (1), S105-S108. DOI:10.1016/j.dsx.2016.12.017

Elgazar, E.H., Esheba, N.E., Shalaby, S.A., & Mohamed, W.F. (2019). Thyroid dysfunction prevalence and relation to glycemic control in patients with type 2 diabetes mellitus. Diabetes Metab. Syndr., 13 (4), 2513-2517. DOI:10.1016/j.dsx.2019.07.020

Han, C., He, X., Xia, X., Li, Y., Shi, X., Shan, Z., & Teng, W. (2015). Subclinical hypothyroidism and type 2 diabetes: A systematic review and meta-analysis. PLoS One, 10 (8), e0135233. DOI:10.1371/journal.pone.0135233

Subekti, I., Pramono, L.A., Dewiasty, E., & Harbu­wono, D.S. (2017). Thyroid dysfunction in type 2 diabetes mellitus patients. Acta Med. Indones, 49 (4), 314-323.

Du, W., Wang, F., Zhao, M., Zhang, H., Zhang, X., Zhao, J., & Gao, L. (2019). Prevalence of thyroid disorders and associated risk factors with various glycemic status in North China. Biotechnology & Biotechnological Equipment, 33 (1), 1244-1250. DOI:10.1080/13102818.2019.1656106

Vanderpump, M.P.J. (2018). Epidemiology of thyroid disease. In Encyclopedia of Endocrine Diseases (pp. 486-495).

Al-Geffari, M., Ahmad, N.A., Al-Sharqawi, A.H., Youssef, A.M., Alnaqeb, D., & Al-Rubeaan, K. (2013). Risk factors for thyroid dysfunction among type 2 diabe­tic patients in a highly diabetes mellitus prevalent society. Int. J. Endocrinol., 2013, 417920. DOI:10.1155/2013/417920

Talwalkar, P., Deshmukh, V., & Bhole, M. (2019). Prevalence of hypothyroidism in patients with type 2 diabetes mellitus and hypertension in India: a cross-sectional observational study. Diabetes Metab. Syndr. Obes., 12, 369-376. DOI:10.2147/DMSO.S181470

Barmpari, M.E., Kokkorou, M., Micheli, A., Alexiou, I., Spanou, E., Noutsou, M., & Thanopoulou, A. (2017). Thyroid dysfunction among Greek patients with type 1 and type 2 diabetes mellitus as a disregarded comorbidity. J. Diabetes Res., 2017, 6505814. doi:10.1155/2017/6505814

Qi, Q., Zhang, Q.M., Li, C.J., Dong, R.N., Li, J.J., Shi, J.Y., . . . Zhang, J.Y. (2017). Association of thyroid-stimulating hormone levels with microvascular complications in type 2 diabetes patients. Med. Sci. Monit., 23, 2715-2720. DOI:10.12659/msm.902006

Ahmed, A.A., Mohamed, S., Elmadi, S.A., Abdorabo, A.A., Ismail, I.M., & Ismail, A.M. (2017). Assessment of thyroid dysfunctions in type 2 diabetes mellitus patients in Surman, Western-Libya. International Journal of Clinical and Experimental Medical Sciences, 3 (1), 1-4. DOI:10.11648/j.ijcems.20170301.11

American Diabetes, A. (2019). 10. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes-2019. Diabetes Care, 42 (Suppl. 1), S103-S123. DOI:10.2337/dc19-S010

Okosieme, O., Gilbert, J., Abraham, P., Boe­laert, K., Dayan, C., Gurnell, M., . . . Vanderpump, M. (2016). Mana­gement of primary hypothyroidism: statement by the British Thyroid Association Executive Committee. Clin. Endocrinol. (Oxf), 84 (6), 799-808. DOI:10.1111/cen.12824

Nair, A., Jayakumari, C., Jabbar, P K., Jayaku­mar, R.V., Raizada, N., Gopi, A., . . . Seena, T.P. (2018). Prevalence and associations of hypothyroidism in Indian patients with type 2 diabetes mellitus. J. Thyroid Res., 2018, 5386129. doi:10.1155/2018/5386129

Khassawneh, A.H., Al-Mistarehi, A.H., Zein Alaabdin, A.M., Khasawneh, L., AlQuran, T.M., Kheirallah, K.A., . . . Obeidat, N. (2020). Prevalence and predictors of thyroid dysfunction among type 2 diabetic patients: A case-control study. Int. J. Gen. Med., 13, 803-816. DOI:10.2147/IJGM.S273900



How to Cite

Musiienko, V. A., & Marushchak, M. I. (2021). TYPE 2 DIABETES MELLITUS AND HYPOTHYROIDISM: LABORATORY DATA. Medical and Clinical Chemistry, (3), 74–79. https://doi.org/10.11603/mcch.2410-681X.2021.i3.12448