PECULIARITIES OF MICROELEMENT COMPOSITION OF TEMPORAL BONE AND LOWER JAW IN THE CONDITIONS OF DIABETIC ARTHROPATHY OF TEMPOROMANDIBULAR JOINT
DOI:
https://doi.org/10.11603/mcch.2410-681X.2021.i2.12235Keywords:
temporomandibular joint, diabetic arthropathy, microelements, temporal bone, lower jawAbstract
Introduction. Joint damage in patients with diabetes is a fairly common complication. Peculiarities of the microelement composition of the temporal bone and mandible and structural changes of the temporomandibular joint in diabetes have been insufficiently studied.
The aim of the study – to learn the features of the microelement composition of the temporal bone and mandible in diabetic arthropathy of the temporomandibular joint.
Research Methods. Atomic absorption spectral analysis examined the content of trace elements (iron, cuprum, zinc, magnesium, manganese, lead) in the temporal bone of the mandible of 45 laboratory mature white male rats, which were divided into 3 groups. Group 1 consisted of 15 intact practically healthy animals, group 2 – 15 rats with monthly diabetic arthropathy of the temporomandibular joint, group 3 – 15 animals with two-month specified pathology. Histological micropreparations were also made from the temporal bone and mandible. Diabetes mellitus was simulated by a single intraperitoneal injection of streptozotocin by Sigma at a dose of 50 mg/kg. Quantitative indicators were processed statistically.
Results and Discussion. It was established that in diabetic arthropathy of the temporomandibular joint the content of iron, cuprum, zinc, magnesium, manganese, lead in the bone tissue of the temporal bone and mandible decreases disproportionately and unevenly. It was found that the iron content in the temporal bone in monthly diabetic arthropathy decreased by 3.4 %, and in the lower jaw – by 4.8 %, in two-month arthropathy, the studied indicators changed by 4.8 % and 13.7 %, respectively (p<0.001). The cuprum content in temporal diabetic arthropathy of the temporomandibular joint in the temporal bone decreased by 3.4 %, in the lower jaw – by 3.8 %, with a two-month course of simulated pathology – by 3.8 % and 11.9 %, respectively (p<0.001). The content of zinc, magnesium, manganese, lead in the temporal bone and mandible in the studied experimental conditions decreased similarly. Changes in the content of the studied microelements depend on the duration of diabetic arthropathy and dominate in the lower jaw.
Conclusions. Diabetic arthropathy of the temporomandibular joint leads to an uneven, disproportionate decrease in the content of microelements in the temporal bone and lower jaw. The most pronounced imbalance between the content of the studied microelements was found in two-month diabetic arthropathy of the temporomandibular joint and in the lower jaw.
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