INVESTIGATION OF THE INFLUENCE OF PHYTOCOMPOSITIONS ON THE PROCESS OF NON-PERMANENT GLYCOSYLATION, ACTIVITY OF CYTOLYTIC PROCESSES, INDICATORS OF LIPID EXCHANGE AND LIPID PEROXIDATION BALANCE IN ANIMAL’S BODY IN EXPERIMENTAL DIABETES

  • Kh. I. Kurylo I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY
  • I. M. Klishch I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY
  • A. S. Volska I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY
  • Ya. V. Rozhkovskyi ODESA NATIONAL MEDICAL UNIVERSITY
Keywords: experimental type 2 diabetes mellitus, goat's-rue, blueberry and taurine phytopreparations

Abstract

Introduction. Diabetes mellitus is one of the global medical, social and economic problems today. The treatment of diabetes requires a comprehensive approach and is based on the use of oral hypoglycemic agents, diet therapy, insulin therapy and phytotherapy. The risk of negative side effects increased with combination drug therapy of diabetes. It is important to find a new mechanism of action that can reduce the level of glycemia and insulin resistance, promote the restoration of insulin-forming function of the pancreas and eliminate the harmful effects of developing oxidative stress. In this regard, it is promising to study the hypoglycemic action of medicinal plants. Establishing the features of the effect of phytocomposition, which contains extracts of goat's-rue, blueberries and taurine, the pathogenetic links of experimental pathological processes and mechanisms of its hypoglycemic activity are of high priority and topical, and the results obtained will contribute to the development of new herbal preparations with hypoglycemic action.

The aim of the study – to find out the metabolitotropic effects and the feasibility of using a liposomal form of phytocomposition based on goat medicinal, blueberries and taurine to improve the efficiency of metabolic shifts correction in experimental diabetes mellitus.

Research Methods. The experiments were performed on adult male rats, which simulated streptozotocin diabetes mellitus, and used Halevit and Arpha-Kombi for correction.

Results and Discussion. Phytocomposites on the basis of goat's-rue and Halevit under conditions of therapeutic and prophylactic use in experimental type 2 diabetes contribute to the restoration of carbohydrate metabolism, improve the state of lipid metabolism, oxidant-antioxidant balance of the body by correction in liver resuspension of reduced glutathione, improve cell energy supply processes by stabilizing blood succinate dehydrogenase activity, causing anticytolytic and detoxication effects, thereby reducing the level of endogenous intoxication.

Conclusion. The results obtained are the basis for further exploration of the possibilities of combined use of herbal medicine based on goat's-rue to reduce side effects.

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Published
2020-02-05
How to Cite
Kurylo, K. I., Klishch, I. M., Volska, A. S., & Rozhkovskyi, Y. V. (2020). INVESTIGATION OF THE INFLUENCE OF PHYTOCOMPOSITIONS ON THE PROCESS OF NON-PERMANENT GLYCOSYLATION, ACTIVITY OF CYTOLYTIC PROCESSES, INDICATORS OF LIPID EXCHANGE AND LIPID PEROXIDATION BALANCE IN ANIMAL’S BODY IN EXPERIMENTAL DIABETES. Medical and Clinical Chemistry, (4), 162-168. https://doi.org/10.11603/mcch.2410-681X.2019.v.i4.10854
Section
ORIGINAL INVESTIGATIONS