INVESTIGATION OF THE INFLUENCE OF PHYTOCOMPOSITIONS ON THE PROCESS OF NON-PERMANENT GLYCOSYLATION, ACTIVITY OF CYTOLYTIC PROCESSES, INDICATORS OF LIPID EXCHANGE AND LIPID PEROXIDATION BALANCE IN ANIMAL’S BODY IN EXPERIMENTAL DIABETES
Introduction. Diabetes mellitus is one of the global medical, social and economic problems today. The treatment of diabetes requires a comprehensive approach and is based on the use of oral hypoglycemic agents, diet therapy, insulin therapy and phytotherapy. The risk of negative side effects increased with combination drug therapy of diabetes. It is important to find a new mechanism of action that can reduce the level of glycemia and insulin resistance, promote the restoration of insulin-forming function of the pancreas and eliminate the harmful effects of developing oxidative stress. In this regard, it is promising to study the hypoglycemic action of medicinal plants. Establishing the features of the effect of phytocomposition, which contains extracts of goat's-rue, blueberries and taurine, the pathogenetic links of experimental pathological processes and mechanisms of its hypoglycemic activity are of high priority and topical, and the results obtained will contribute to the development of new herbal preparations with hypoglycemic action.
The aim of the study – to find out the metabolitotropic effects and the feasibility of using a liposomal form of phytocomposition based on goat medicinal, blueberries and taurine to improve the efficiency of metabolic shifts correction in experimental diabetes mellitus.
Research Methods. The experiments were performed on adult male rats, which simulated streptozotocin diabetes mellitus, and used Halevit and Arpha-Kombi for correction.
Results and Discussion. Phytocomposites on the basis of goat's-rue and Halevit under conditions of therapeutic and prophylactic use in experimental type 2 diabetes contribute to the restoration of carbohydrate metabolism, improve the state of lipid metabolism, oxidant-antioxidant balance of the body by correction in liver resuspension of reduced glutathione, improve cell energy supply processes by stabilizing blood succinate dehydrogenase activity, causing anticytolytic and detoxication effects, thereby reducing the level of endogenous intoxication.
Conclusion. The results obtained are the basis for further exploration of the possibilities of combined use of herbal medicine based on goat's-rue to reduce side effects.
Tronko, N.D., Karachentsev, Yu.I., Sokolova, L.K., & Kravchun, N.A. (2016). Aktualnyye aspekty insulinoterapii u patsiyentov s sakharnym diabetom [Actual aspects of insulin therapy in patients with diabetes mellitus]. Endokrinologiya – Endocrinology, 21, 2, 100-107 [in Russian].
Maslova, N.F., Bomko, T.V., & Litvinova, Ye.V. (2017). Farmakologicheskoye deystviye metfonorma na modeli sakharnogo diabeta 2 tipa u krys starogo vozrasta [Pharmacological effect of methonorm on a model of type 2 diabetes mellitus in old rats]. Farmakom – Farmakom, 1, 46-50 [in Russian].
Kharroubi, А.Т. (2015). Diabetes mellitus: The epidemic of the century. World Journal of Diabetes, 6, 850.
Muravlova, O.V. (2015). Terapiia tsukrovoho diabetu 2-ho typu: efektyvnist, yaka dovedena chasom [Type 2 diabetes therapy: time-based efficacy]. Mir meditsyny i biologii – World of Medicine and Biology, 11 (4-1), 53-56 [in Ukrainian].
Ezhned, M.A., Hroshovyi, T.A., & Horoshko, O.M. (2016). Osoblyvosti tsukroznyzhuvalnoi dii sukhoho ekstraktu z koreniv ta korenevyshch kulbaby likarskoi zalezhno vid dozy [Peculiarities of sugar-lowering effect of dry extract from the roots and rhizomes of medicinal dandelion depending on the dose]. Farmatsevtychnyi chasopys – Pharmaceutical Journal, 1, 85-88 [in Ukrainian].
Burda, N.Ye., Klyvniak, B.M., Rozhkovskyi, Ya.V., & Zhuravel, I.O. (2015). Vyznachennia rutynu v syrovyni yakirtsiv slankykh [Determination of routine in raw materials of shale anchors]. Farmkhimiia ta farmakohnoziia – Pharmachemistry and Pharmacognosy, 24 (5), 49-52 [in Ukrainian].
Mykhailenko, O.Yu. (2015). Suchasna terapiia tsukrovoho diabetu 2-ho typu z vykorystanniam predstavnyka hrupy preparativ sulfonilsechovyny – hliklazydu spovilnenoho vyvilnennia vyrobnytstva PAT “Farmak” [Modern therapy of type 2 diabetes with the use of a representative of a group of drugs sulfonylurea – glyclazide delayed release of production of PJSC “Pharmak”]. Mezhdunarodnyy endokrynologicheskyy zhurnal – International Endocrinological Journal, 2 (66), 52-56 [in Ukrainian].
Korsun, V.F., Trumpe, T.Ye., Korsun, Ye.V., Yershov, N.V., & Ogrenich, N.A. (2015). Fitoterapiya protiv diabeta [Phytotherapy against diabetes] Moscow: Tsentrpoligraf [in Russian].
Khokhla, M., Hachkova, H., & Sybirna, N. (2016). Porivnyannia hipohlikemichnoi dii vodnykh ekstraktiv, suspenzii yakona ta bezalkaloidnoi fraktsii ekstraktu halehy likarskoi [Comparison of hypoglycemic action of aqueous extracts, anchors suspensions and non-alkaloid fraction of hollow drug extract]. Visnyk Lvivskoho universytetu – Bulletin of the Lviv University, (73), 421-428 [in Ukrainian].
Zagayko, A.L., Voytenko, Ye.I., & Filimonenko, V.P. (2015). Vliyaniye ekstrakta listyev cherniki na pokazateli razvitiya eksperimentalnogo sakharnogo diabeta 2 tipa [The effect of blueberry leaf extract on the development of experimental type 2 diabetes mellitus]. Ukrainskiy biofarmatsevticheskiy zhurnal – Ukrainian Biopharmaceutical Journal, 1, 43-46 [in Russian].
Ostapiv, R.D., Kystsiv, O.S., & Manko V.V. (2015). Vplyv tryvaloho peroralnoho vvedennia taurynu na fiziolohichni pokaznyky shchuriv [Effect of long-term oral administration of taurine on the physiological parameters of rats]. Visnyk Lvivskoho universytetu – Bulletin of the Lviv University, 69, 247-255.
Islam, S., & Choi, H. (2011). Comparative effects of dietary ginger and garlic investigated in tape 2 diabetes model of rats. Jornal of Medicinal Foods. (1), 152-159.
Islam, S., & Choi, H. (2007). Nongenetic model of type 2 diabetes: a comparative study. Pharmacology, 79, 243-249.
Stefanova, A.V. (2001). Doklinicheskiye issledovaniya lekarstvennykh sredstv [Preclinical studies of drugs]. Kyiv: Avitsena [in Ukrainian].