INFLUENCE OF LOWER LIMBS REPERFUSION ON THE DYNAMICS OF CHANGES IN THE INDICATORS OF ENDOGENIC INTOXICATION IN CONDITIONS OF COMBINED ABDOMINAL INJURY AND MASSIVE BLOOD LOOS

  • O. V. Fedoseeva UKRAINIAN SCIENTIFIC AND PRACTICAL CENTER OF EMERGENCY AND DISASTER MEDICINE, MINISTRY OF HEALTH OF UKRAINE, KYIV
Keywords: combined trauma, endogenous intoxication, reperfusion, massive blood loss, experiment, lungs

Abstract

Introduction. The article presents the results of an experimental study that investigated the effect of lower extremity reperfusion on the development of endogenous intoxication with closed trauma of the abdominal organs and massive external blood loss. It is known that endogenous intoxication is a complex multicomponent process, caused by pathological biological activity of endogenous products or dysfunction of natural detoxification systems. The results of the study showed that reperfusion of the lower extremities enhances the development of endogenous intoxication with combined trauma in the experiment.

The aim of the study – to learn the effect of lower extremity reperfusion on changes in endogenous intoxication in a model of combined injury of abdominal organs against the background of massive blood loss.

Materials and Methods. An experiment was conducted on 80 non-linear male rats weighing 190–220 grams. In the experimental groups, reperfusion of the lower extremities in combination with closed trauma of the abdominal organs was simulated against the background of massive blood loss and the content of markers of endogenous intoxication (molecules of the average mass of fractions determined at 254 and 280 nm) and erythrocytic intoxication index were analyzed. The likelihood of differences between the control group and the study group was evaluated using the non-parametric Mann-Whitney test.

Results and Discussion. The imposition of hemostatic strap on the two lower extremities caused a significant increase in endogenous intoxication index in all study groups. The maximum increase in the endogenous intoxication index was in the group where the tourniquet was combined with trauma to the abdominal cavity and massive blood loss. This proved the potentiating effect of reperfusion syndrome on the development of systemic changes in combined trauma. It is also proved that the manifestation of endogenous intoxication during the first 24 hours after the imposition of hemostatic straps is similar to that resulting from the combined injury of the abdominal organs against the background of massive external bleeding.

Conclusion. The imposition of hemostatic bundles on the two lower extremities, within two hours, increases the development of endogenous intoxication in the model of combined injury of the abdominal organs against the background of massive blood loss, which is confirmed by a significant increase in the endogenous intoxication index and dementia molecules.

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Published
2020-02-03
How to Cite
Fedoseeva, O. V. (2020). INFLUENCE OF LOWER LIMBS REPERFUSION ON THE DYNAMICS OF CHANGES IN THE INDICATORS OF ENDOGENIC INTOXICATION IN CONDITIONS OF COMBINED ABDOMINAL INJURY AND MASSIVE BLOOD LOOS. Medical and Clinical Chemistry, (4), 37-43. https://doi.org/10.11603/mcch.2410-681X.2019.v.i4.10826
Section
ORIGINAL INVESTIGATIONS