MARKERS OF BONE TURNOVER IN THE TREATMENT AND CONTROL OF COMPLEX THERAPY OF GENERALIZED PERIODONTITIS
DOI:
https://doi.org/10.11603/1811-2471.2023.v.i4.14111Keywords:
generalized periodontitis, treatment, osteoporosis, biochemical markersAbstract
SUMMARY. The search and justification for the use of pathogenetic therapy, differentiated prescription of drugs in accordance with the clinic of periodontitis, dental status and general somatic condition of patients is the main direction of modern periodontology. It is known that one of the main indicators of the effectiveness of treatment of generalized periodontitis is considered to be long-term results after treatment, which provide objective information about quantitative and qualitative changes in clinical and paraclinical signs of the condition of periodontal tissues, allowing one to judge the presence or absence of clinical and radiological stabilization.
The aim – to evaluate the effectiveness of treatment of generalized periodontitis in women after oophorectomy based on the state of bone tissue remodeling processes.
Material and Methods. Clinical and radiological periodontal tissues and laboratory studies of bone metabolism markers were carried out in 60 women who had undergone oophorectomy and suffered from generalized periodontitis.
Results. In the long term after treatment, a decrease in the osteoporosis activity index was observed in all observation groups. Positive dynamics of the osteoporotic process index in the alveolar process meant inhibition of increased resorptive processes and increased osteogenesis. The normalization of bone metabolism was evidenced by a decrease in hydroxyproline levels and an increase in osteocalcin levels in patients of the first and second observation groups.
Conclusion. The results of the study confirm the need to identify three forms of activity of the osteoporotic process in the alveolar bone for a further differentiated approach in the complex treatment of generalized periodontitis. For women with inactive foci of osteoporosis in the alveolar process, it is advisable to use Calcium-D3 Nycomed. In the presence of moderately active and active foci of osteoporosis in the bone structures of the periodontium, it is more advisable to prescribe calcium supplements and antiresorptive agents in combination with drugs that normalize hormonal levels. Taking into account the established features, a complex pathogenetically substantiated method of treating generalized periodontitis in this group of patients has been developed and tested. It provides, along with basic therapy, the prescription of Calcium-D3 Nycomed, Fosamax and Proginova.
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