АКТУАЛЬНІ ПИТАННЯ ХВОРОБИ ЛАЙМА У ДІТЕЙ

С. О. Никитюк; С. І. Климнюк

doi:10.11603/1811-2471.2021.v.i3.12505

Автор(и)

С. О. Никитюк Тернопільський національний медичний університет імені І. Я. Горбачевського МОЗ України
С. І. Климнюк Тернопільський національний медичний університет імені І. Я. Горбачевського МОЗ України

DOI:

https://doi.org/10.11603/1811-2471.2021.v.i3.12505

Ключові слова:

діти, Лайм-бореліоз, діагностика, лікування, кліщі

Анотація

Хвороба Лайма має різні клінічні прояви, її слід виключити у всіх пацієнтів з укусом кліща. Хвороба Лайма викликається Borrelia burgdorferi senso lato, збудником гетерогенної групи, з якої три гени систематично асоціюються із хворобою Лайма: B. burgdorferi senso stricto, B. afzelii і B. garinii, і є ендемічною хворобою в Україні.

Ранні клінічні маркери Лайм-бореліозу та інші прогностичні фактори, що загрожують життю дитини, ускладнення бореліозної інфекції, все ще перебувають на початку активного дослідження вченими.

Висновки. Клініцисти, включаючи сімейних лікарів, ревматологів, імунологів та молекулярних кардіологів, повинні брати участь у розробці нових критеріїв, що включають клінічну картину та результати лабораторного дослідження.

Посилання

Hsieh, Y.F., Liu, H.W., Hsu, T.C., Wei, J.C., Shih, C.M., Krause, P.J., & Tsay, G.J. (2007). Serum reactivity against Borrelia burgdorferi OspA in patients with rheumatoid arthritis. Clin. Vaccine Immunol., 14 (11), 1437-1441. DOI: 10.1128/CVI.00151-07.

Dryden, M.S., Saeed, K., Ogborn, S., & Swales, P. (2015). Lyme borreliosis in southern United Kingdom and a case for a new syndrome, chronic arthropod-borne neuropathy. Epidemiol. Infect., 143 (3), 561-572. DOI: 10.1017/S0950268814001071.

Böhmer, M.M., Ens, K., Böhm, S., Heinzinger, S., & Fingerle, V. (2021). Epidemiological surveillance of Lyme borreliosis in Bavaria, Germany, 2013–2020. Microorganisms, 9 (9), 1872. DOI: 10.3390/microorganisms9091872.

Stanek, G., & Reiter, M. (2011). The expanding Lyme Borrelia complex – clinical significance of genomic species? Clin. Microbiol. Infect., 17 (4), 487-493. DOI: 10.1111/ j.1469-0691.2011.03492.x.

Strle, F., & Stanek, G. (2009). Clinical manifestations and diagnosis of Lyme borreliosis. Curr. Probl. Dermatol., 37, 51-110. DOI: 10.1159/000213070.

Shkilna, M.I. (2016). Laym-borelioz u pratsivnykiv lisovykh hospodarstv Ternopilskoi oblasti [Lyme borreliosis in forestry workers of Ternopil region]. Infektsiini khvoroby – Infect. Dis., 1 (83), 36-40. DOI: https://doi.org/10.11603/1681-2727.2016.1.5957 [in Ukrainian].

Nykytyuk, S.O., Kostyk, M.M., Kizan, S.V., & Borys, Z. Ya. (2018). Vypadok hostroho neiroboreliozu u khlopchyka shkilnoho viku [Case report of acute neuroborreliosis in a school-age boy]. Aktualna infektolohiia – Actual Infectology, 6, 4, 53-54. DOI: 0.22141/2312-413x.6.4.2018.142475 [in Ukrainian].

Norman, G.L., Antig, J.M., Bigaignon, G., & Hogrefe, W.R. (1996). Serodiagnosis of Lyme borreliosis by Borrelia burgdorferi sensu stricto, B. garinii, and B. afzelii western blots (immunoblots). J. Clin. Microbiol., 34 (7), 1732-1738. DOI: 10.1128/JCM.34.7.1732-1738.1996.

Centers for disease control and prevention (2012). Reported cases of Lyme disease by year, United States, 2002–2011. Retrieved from: http://www.cdc.gov/lyme/stats/chartstables/casesbyyear.html.

Andreichyn, M.A., Shkilna, M.I., & Nykytiuk, S.O. (2017). Chastota vyiavlennia borelii i anaplazmy u klishchiv, vyluchenykh vid meshkantsiv Ternopilskoi oblasti [Frequency of detection of Borellia and anaplasma at the tick extracted from the residents of Ternopil region]. Epidemiolohichni ta klinichni uskladnennia infektsiinykh i parazytarnykh khvorob u suchasnykh umovakh – Epidemiological and clinical harmonization of infectious and parasitic diseases in modern conditions. Proceedings of the All-Ukrainian scientific-practical conference of infectious disease specialists and plenum of the All-Ukrainian Association of Infectious Diseases NGOs (pp. 9-11). Ternopil: Ukrmedknyha [in Ukrainian].

Nykytyuk, S., & Klymnyuk, S. (2021). Clinical and immunological status of children with lyme disease. Health Problems of Civilization. DOI: https://doi.org/10.5114/hpc.2021.108379.

Yoon, E.C., Vail, E., Kleinman, G., Lento, P.A., Li, S., Wang, G., ..., & Fallon, J.T. (2015). Lyme disease: a case report of a 17-year-old male with fatal Lyme carditis. Cardiovasc. Pathol., 24 (5), 317-321. DOI: 10.1016/j.carpath.2015.03.003.

Tsentr hromadskoho zdorovia Ukrainy [Center for Public Health of Ukraine]. MOZ (phc.org.ua). Retrieved from: https://phc.org.ua [in Ukrainian].

Steere, A.C. (2001). Lyme disease. N. Engl. J. Med., 345 (2), 115-125. DOI: 10.1056/nejm200107123450207.

Philip, S.S. (2013). Current medical diagnosis and treatment. Spirochetal Infections. New York: Mc-Graw-Hill. Retrieved from: http://www.accessmedicine.com.eres.library.manoa.hawaii.edu/content.aspx?aID=18802&searchStr=lyme+disease.

Caulfield, A.J., & Pritt, B.S. (2015). Lyme disease coinfections in the United States. Clin. Lab. Med., 35 (4), 827-846.

Wilking, H. (2014). Trends in surveillance data of human Lyme borreliosis from six federal states in eastern Germany. Ticks Tick Borne Dis., 5 (3), 219-224.

Krause, P.J., McKay, K., Thompson, C.A., Sikand, V.K., Lentz, R., Lepore, T., …, & Spielman, A. (2002). Disease-specific diagnosis of co-infecting tick-borne zoonoses: Babesiosis, human granulocytic ehrlichiosis, and Lyme disease. Clin. Infect. Dis., 34 (9), 11841191. DOI: 10.1086/339813.

Krause, P.J., Fish, D., Narasimhan, S., & Barbour, A.G. (2015). Borrelia miyamatoi infection in nature and in humans. Clin. Microbiol. Infect., 21 (17), 631-639. DOI: 10.1016/j.cmi.2015.02.006.

Cutler, S.J., Rudenko, N., Golovchenko, M., Cramaro, W.J., Kirpach, J., Savic, S., Christova, I., & Amaro, A. (2017). Diagnosing borreliosis. Vector-Borne Zoonotic Dis., 17, 2-11. DOI: 10.1089/vbz.2016.1962.

Nyman, D., & Wahlberg, P. (2017). Lyme borreliosis (LB). EBM Guidelines. Retrieved from: https://www.ebmguidelines.com/dtk/ebmaz/avaa?p_artikkeli=ebm00031.

Steer, A.C. (2010). Lyme borreliosis. Harrison’s infectious diseases. Casper, D.L., & Fauci, A.S. eds. 17th edn. New York: the McGraw-Hill Companies.

Murina, Е.А., Goleva, O.V., Osipova, Z.A., & Mukomolova, A.L. (2018). Problemy serologicheskoy diagnostiki iksodovogo kleshchevogo borrelioza u detey [The problems of serologicl diagnostics of tick-borne borreliosis in children]. Laboratoriya LPU. Spetsvypusk – LPU laboratory. Special Issue, 13, 38-40. Retrieved from: http://www.poliklin.ru/imagearticle/20184(1)/38.pdf [in Russian].

Stanek, G., Wormser, G.P., Gray, J., & Strle, F. (2012). Lyme borreliosis. Lancet, 379, 461-473. DOI: 10.1016/S0140-6736(11)60103-7.

Bartosik, K., Kubrak, T., Olszewski, T., Jung, M., & Buczek, A. (2008). Prevention of tick bites and protection against tick-borne diseases in south-eastern Poland. Ann. Agric. Environ. Med., 15 (2), 181-185.

Perelik osoblyvo nebezpechnykh, nebezpechnykh infektsiinykh ta parazytarnykh khvorob liudyny ta nosiiv zbudnykiv tsykh khvorob [List of especially dangerous, dangerous infectious and parasitic human diseases and carriers of pathogens of these diseases]. Nakaz Ministerstva okhorony zdorovia Ukrainy vid 19.07.1995 r. № 133 – Order of the Ministry of Health of Ukraine dated 19.07.1995. No. 133 [in Ukrainian].

(2017). Centers for Disease Control and Prevention. Lyme disease (Borrelia burgdorferi): 2017 case definition. Retrieved from: https://wwwn.cdc.gov/nndss/conditions/ lyme-disease/case-definition/2017.

Stanek, G., Fingerle, V., Hunfeld, K.P., Jaulhac, B., Kaiser, R., Krause, A., …, & Gray, J. (2011). Lyme borreliosis: clinical case definitions for diagnosis and management in Europe. Clin. Microbiol. Infect., 17 (1), 69-79. DOI: 10.1111/ j.1469-0691.2010.03175.x.

Kramarov, S.O., & Holubovska, O.A. (2019). Infektsiini khvoroby: entsyklopedychnyi dovidnyk [Infectious diseases: encyclopedic reference book]. 2nd edn., revised and suppl. Kyiv: TOV “Harmoniia” 712 p. [in Ukrainian].

Sigal, L.H. (1995). Early disseminated Lyme disease: cardiac manifestations. Am. J. Med., 98 (4A), 25S-28S, discussion 28S-29S. DOI: 10.1016/S0002-9343(99)80041-2.

Karavayev, V.S., Oleynikova, Ye.S., Azayev, M.Sh., & Beklemishev, A.B. (2016). Immunokhimicheskiy analiz rekombinantnogokhimernogo polipeptida OspC [gar+afz] izolyatov b. garini i b. afzelli [Immunochemical analysis of the recombinant chimeric OspC polypeptide [gar + afz] b. garini and b. afzelli]. Zhurnal mikrobiologii, epidemiologii i immunobiologii – J. Microbiol., Epidemiol. Immunobiol., 3, 37-44 [in Russian].

Smiyan, S., Galaychuk, I., Zhulkevych, I., Nykolyuk, V., Komorovsky, R., Gusak, S., Bilozetsky, I. (2019). Sjögren’s syndrome and lymphadenopathy unraveling the diagnosis of Lyme diseas. Reumatologia, 57 (1), 59-62. Retrieved from: https://doi.org/10.5114/reum.2019.83242.

Dahl, V., Wisell, K.T., Giske, C.G., Tegnell, A., & Wallensten, A. (2019). Lyme neuroborreliosis epidemiology in Sweden 2010 to 2014: clinical microbiology laboratories are a better data source than the hospital discharge diagnosis register separator commenting unavailable. Euro. Surveill, 24 (20). DOI: 10.2807/1560-7917.ES.2019.24.20.1800453.

[Electronic resource]. Retrieved from: https://guidelines.moz.gov.ua/documents/2959.

Bacon, R.M., Kugeler, K.J., & Mead, P.S. (2008). Centers for Disease Control and Prevention (CDC) Surveillance for Lyme disease-United States, 1992-2006. MMWR Surveill Summ., 57 (10), 1-9.

Nyman, D., & Wahlberg, P. (2017). Lyme borreliosis (LB) EBM Guidelines. Retrieved from: https://www.ebm-guidelines.com/dtk/ebmaz/avaa?p_artikkeli=ebm00031.

Steere, A.C., McHugh, G., Suarez, C., Hoitt, J., Damle, N., & Sikand, V.K. (2003). Prospective study of coinfection in patients with erythema migrans. Clin. Infect. Dis., 36 (8), 1078-1081. DOI: 10.1086/368187.

Weber, K. (2001). Aspects of Lyme borreliosis in Europe. Eur. J. Clin. Microbiol. Infect. Dis., 20 (1), 6-13. DOI: 10.1007/s100960000412.

(2019). Tsentralizovannaya informatsionnaya sistema po infektsionnym zabolevaniyam Yevropeyskogo regionarnogo byuro VOZ [Centralized Information System for Infectious Diseases of the WHO European Regional Bureau]. Retrieved from: http://www.euro.who.int/en/search?q=lyme+disease+in+ukraine.

Karan, L., Makenov, M., Kolyasnikova, N., Stukolova, O., Toporkova, M., Olenkova, O., …, & Olenkova, O. (2018). Dynamics of spirochetemia and early PCR detection of Borrelia miyamotoi. Emerg. Infect. Dis., 24 (5), 860-867. DOI: 10.3201/eid2405.170829.

Klymniuk, S.I., Romaniuk, L.B., & Shkilna, M.I. (2017). Suchasni uiavlennia pro hranulotsytarnyi anaplazmoz liudyny [Modern views about the granulocytic anaplasmosis of a man]. Infektsiini khvoroby – Infect. Dis., 3, 4-9. DOI: 10.11603/1681-2727.2017.3.8220.

Steere, A.C., Coburn J., & Glickstein L. (2004). The emergence of Lyme disease. J. Clin. Invest., 113 (8), 1093-1101. DOI: 10.1172/JCI21681.

Penevskaya, N.A., Rudakov, N.V., Abramova, N.V., Rudakova, S.A., & Kolomensky, A.P. (2009). Kliniko-epidemiologicheskiy analiz rezultatov vyyavleniya antitel k razlichnym vidam rikketsiy u bolnykh s podozreniyem na kleshchevuyu neyroinfektsiyu v severnykh rayonakh Omskoy oblasti [Clinical and epidemiological analysis of the results of detecting antibodies to various types of rickettsia in patients with suspected tick-borne neuroinfection in the northern regions of the Omsk region]. Sibirskiy meditsinskiy zhurnal – Siberian Med. J., 8, 48-53 [in Russian].

Logigian, E.L., Kaplan, R.F., & Steere, A.C. (1990). Neurologic manifestations of Lyme disease. N. Engl. J. Med., 323 (21), 1438. DOI: 10.1056/NEJM199011223232102.

Nau, R., Christen, H.J., & Eiffert, H. (2009). Lyme disease: current state of knowledge. Dtsch. Arztebl. Int., 106 (95), 72-81. DOI: 10.3238/arztebl.2009.0072.

Drakina, S.A., Anisko, L.A., Shcherba, V.V., Samoylova, T.I., & Krasko, A.G (2018). Mikst-infektsiya: kleshchevoy entsefalit i granulotsitarniy anaplazmoz cheloveka [Mixed infection: tick-borne encephalitis and human granulocytic anaplasmosis]. Klinicheskaya infektologiya i parazitologiya – Clinical Infectology and Parasitology, 1, 21-26 [in Russian].

Halperin, J.J. (2010). Nervous system Lyme disease. J. R. Coll. Physicians Edinb., 40 (3), 248-255. DOI: 10.4997/JRCPE.2010.314.

Södermark, L., Sigurdsson, V., Näs, W., Wall, P., & Trollfors, B. (2017). Neuroborreliosis in Swedish children: A Population-based study on incidence and clinical characteristics. Pediatr. Infect. Dis. J., 36 (11), 1052-1056. DOI: 10.1097/INF.0000000000001653.

Mygland, A., Ljøstad, U., Fingerle, V., Rupprecht, T., Schmutzhard, E., & Steiner, I. (2010). EFNS guidelines on the diagnosis and managementof European Lyme neuroborreliosis. Eur. J. Neurology, 17, 8-16. DOI: 10.1111/j.1468- 1331.2009.02862.x.

Remiker, A., Haslam, D., & Kalfa, T.A. (2020). A painless erythematous swelling of the external ear as a manifestation of Lyme disease. J. Med. Case Rep., 14 (48), 48. DOI: 10.1186/s13256-020-02377-x.

Dressler, F., Ackermann, R., & Steere, A.C. (1994). Antibody responses to the three genomic groups of Borrelia burgdorferi in European Lyme borreliosis. J. Infect. Dis., 169 (2), 313-318. DOI: 10.1093/infdis/169.2.313.

Henningsson, A.J., Christiansson, M., Tjernberg, I., & Löfgren, S. (2014). Laboratory diagnosis of Lyme neuroborreliosis: acomparison of three CSF anti-Borrelia antibody assays. Eur. J. Clin. Microbial Infect. Dis., 33 (5), 797-803. DOI: 10.1007/s10096-013-2014-6.

Galaychuk, I.Y., Zhulkevych, I.V., Smiyan, S.I., Nykolyuk, V.D., & Komorovsky, R.R. (2019). Boreliozna limfadenopatiia u praktytsi onkoloha (klinichni sposterezhennia) [Borrelious lymphadenopathy in oncology practice (clinical observations)]. Onkolohiia – Oncology, 21 (3), 250-253. DOI: 10.32471/oncology.2663-7928.t-21-3-2019-7896 [in Ukrainian].

Lobzin, Yu.V., Rakhmanova, A.G., & Antonov, V.S. (2000). Rekomendatsii dlya vrachey [Recommendations for doctors]. Saint Petersburg [in Russian].

Volokha, A.P. (2016). Khvoroba Laima (klishchovyi borelioz). Infektsiini khvoroby u ditei [Lyme disease (tick-borne borreliosis). Infectious diseases in children]. Chernyshova L.I., ed. Kyiv: VSV «Medytsyna» [in Ukrainian].

Steere, A.C., Malawista, S.E., Snydman, D.R., Shope, R.E., Andiman, W.A., Ross, M.R., & Steele, F.M. (1977). Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three Connecticut communities. Arthritis Rheum., 20 (1), 7-17. DOI: 10.1002/art.1780200102.

Steere, A.C., & Angelis, S.M. (2006). Therapy for Lyme arthritis: strategies for the treatment of antibiotic-refractory arthritis. Arthritis Rheum., 54 (10), 3079-3086. DOI: 10.1002/art.22131.

Stanek, G., Wormser, G.P., Gray, J., & Strle, F. (2012). Lyme borreliosis. Lancet, 379 (9814), 461-473. DOI: 10.1016/S0140-6736(11)60103-7.

Arvikar, S.L., & Steere, A.C. (2015). Diagnosis and treatment of Lyme arthritis. Infect. Dis. Clin. North. Am., 29 (2), 269-280. DOI: 10.1016/j.idc.2015.02.004

Wormser, G.P., Brisson, D., & Liveris, D. (2008). Borrelia burgdorferi genotype predicts the capacity for hematogenous dissemination during early lyme disease. J. Infect. Dis., 198 (9), 1358-1364. DOI: 10.1086/592279.

Caforio, A.L., Pankuweit, S., Arbustini, E., Basso, C., Gimeno-Blanes, J., Felix, S.B., …, & Elliott, P.M. (2013). Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Disease. Eur. Heart J., 34 (33), 2634-2648. DOI: 10.1093/eurheart/eht210

Nelson, C.A., Saha, S., Kugeler, K.J., Delorey, M.J., Shankar, M.B., Hinckley, A.F., & Mead, P.S. (2015). Incidence of clinician-diagnosed Lyme disease, United States, 2005–2010. Emerging Infect. Dis., 21 (9), 1625-1631. DOI: 10.3201/eid2109.150417.

Yeung, C., & Baranchuk, A. (2019). Diagnosis and treatment of Lyme carditis: JACC review topic of the week. J. Am. Coll. Cardiol., 73 (6), 717-726. DOI: 10.1016/j.jacc.2018.11.035.

Torbey, E., Nalluri, N., Karam, B., Agarwal, V., & Bekheit, S. (2015). Conduction riddles of Lyme carditis: a case series. J. Innov. Card. Rhythm. Manag., 6 (5), 2004-2007. DOI: 10.7759/cureus.5554.

Nassar-Sheikh Rashid, A., Boele van Hensbroek, M., Kolader, M., Hovius, J.W., & Pajkrt, D. (2018). Lyme borreliosis in children: a tertiary referral hospital–based retrospectiveanalysis. Pediatr. Infect. Dis. J., 37 (2), e45-e47. DOI: 10.1097/INF.0000000000001735.

Shah, S.S., Zaoutis, T.E., Turnquist, J., Hodinka, R.L., & Coffin, S.E. (2005). Early differentiation of Lyme from enteroviral meningitis. Pediatr. Infect. Dis. J., 24 (6), 542-545. DOI: 10.1097/01.inf.0000164767.73746.6e.

Thompson, A.D., Cohn, K.A., Shah, S.S., Lyons, T., Welsh, E.J., Hines, E.M., & Nigrovic, L.E. (2012). Treatment complications in children with Lyme meningitis. Pediatr. Infect. Dis. J., 31 (10), 1032-1035. DOI: 10.1097/INF.0b013e31825eb3c7.

Cruickshank, M., O'Flynn, N., & Faust, S.N. (2018). Lyme disease: summary of NICE guidance. Br. Med. J., 361, k1261. DOI: https://doi.org/10.1136/bmj.k1261.

Garro, A.C., Rutman, M.S., Simonsen, K., Jaeger, J.L., Chapin, K., & Lockhart, G. (2011). Prevalence of Lyme meningitis in children with aseptic meningitis in a Lyme disease-endemic region. Pediatr. Infect. Dis. J., 30 (11), 990-992. DOI: 10.1097/INF.0b013e31822e8e68.

Peltomaa, M., Saxen, H., Seppälä, I., Viljanen, M., & Pyykkö, I. (1998). Paediatric facial paralysis caused by Lyme borreliosis: a prospective and retrospective analysis. Scand. J. Infect. Dis., 30 (3), 269-275. DOI: 10.1080/00365549850160927.

Nykytyuk, S., Boyarchuk, O., Klymnyuk, S., & Levenets, S. (2020). The Jarisch-Herxheimer reaction associated with doxycycline in a patient with Lyme arthritis. Reumatologia, 58 (5). 335-338. DOI: 10.5114/reum.2020.99143.

Weber, K. (1988). Jarish-Herxheimer-Reaktion bei erythema migrans-Krankheit. Hautarzt, 35, 588-590.

Ljøstad, U., & Mygland, Å. (2012). The phenomenon of ‘chronic Lyme’; an observational study. Eur. J. Neurol., 19 (8), 1128-1135. DOI: 10.1111/j.1468-1331.2012.03691.x.