COMBORBIDITY OF CHRONIC OBSTRUCTIVE LUNG DISEASE WITH ARTERIAL HYPERTENSION: THE STATE OF THE ANTIOXIDANT DEFENSE SYSTEM
DOI:
https://doi.org/10.11603/bmbr.2706-6290.2019.1.10517Keywords:
chronic obstructive pulmonary disease, arterial hypertension, comorbidity, antioxidant defense systemAbstract
The aim of the work. Evaluating the status of the antioxidant protection system in patients with a comorbid course of chronic obstructive pulmonary disease and hypertension.
Materials and Methods. The research included 53 patients with COPD, 28 of them had arterial hypertension and were at inpatient treatment. The condition of antioxidant protection system (AOP) was evaluated for the activity of primary protection enzymes – superoxide dismutases (SOD) and catalase, as well as the content of ceruloplasmin (CP).
Results and Discussion. In the analysis of indicators of the antioxidant protection system was noted the violation of antioxidant reserves in patients with COPD and with comorbidity COPD and AH. So, the activity SOD at comorbidity course COPD and AH decreased by 31.4 %, while catalase activity was twice lower against control data. The contents of CP in patients with COPD and AH was higher by 94.3 %, in relation to control values.
Conclusions. The common risk factors of COPD and AH, intensification of systemic inflammation at aggravation COPD are accompanied by a cascade of pathophysiological mechanisms, one of them is oxidative stress, which is related to depletion of antioxidant reserves (likely decrease in activity of superoxide dismutases and catalase, increasing the content of ceruloplasmin).
References
WHO global report on trends in prevalence of tobacco smoking. 2015.
Gordon SB, Bruce NG, Grigg J, Hibberd PL, Kurmi OP, Lam KB, Mortimer K. Respiratory risks from household air pollution in low and middle income countries. Lancet Respir Med. 2014; 2(10): 823-60. DOI: https://doi.org/10.1016/S2213-2600(14)70168-7
Chronic obstructive pulmonary disease (COPD). Available at: https://www.who.int/news-room/fact-sheets/detail/chronic-obstructive-pulmonary-disease-(copd).
Pock M, Czypionka T, Reiss M, Röhrling G. Economic burden of chronic respiratory diseases in Austria and Slovenia Results of a life-cycle model. 2018. Available at: http://irihs.ihs.ac.at/4663/1/2018-ihs-report-pock-czypionka-reiss-copd-chronic-respiratory-diseases-austria-slovenia.pdf.
Burney P, Jithoo A, Kato B, Janson C, Mannino D, Nizankowska-Mogilnicka E, Studnicka M, et al. Chronic obstructive pulmonary disease mortality and prevalence: the associations with smoking and poverty – a BOLD analysis. Thorax. 2014; 69: 465-73. DOI: https://doi.org/10.1136/thoraxjnl-2013-204460
Ciapponi A, Alison L, Agustina M, Demián G, Silvana C, Edgardo S. The epidemiology and burden of COPD in Latin America and the Caribbean: systematic review and meta-analysis. COPD. 2014;11: 339-50.
Diaz-Guzman E, Mannino DM. Epidemiology and prevalence of chronic obstructive pulmonary disease. Clin Chest Med. 2014;35: 7-16. DOI: https://doi.org/10.1016/j.ccm.2013.10.002
Fukuchi Y, Nishimura M, Ichinose M, Adachi M, Nagai A, Kuriyama T, Takahashi K et al. COPD in Japan: the Nippon COPD epidemiology study. Respirology. 2004;9: 458-65. DOI: https://doi.org/10.1111/j.1440-1843.2004.00637.x
Canadian Chronic Disease Surveillance System (CCDSS). Available at: https://infobase.phac-aspc.gc.ca/ccdss-scsmc/data-tool/.
India State-Level Disease Burden Initiative CRD Collaborators. The burden of chronic respiratory diseases and their heterogeneity across the states of India: the Global Burden of Disease Study 1990–2016. Lancet Glob Health. 2018;6: e1363–74.
Adeloye D, Chua S, Lee C, Basquill C, Papana A, Theodoratou E, Nair H, et al. Global and regional estimates of COPD prevalence: systematic review and meta-analysis. J Glob Health. 2015; 5:020415. DOI: https://doi.org/10.7189/jogh.05.020415
Work-related chronic obstructive pulmonary di-sease (COPD) in Great Britain, 2018; http://www.hse.gov.uk/statistics/causdis/copd.pdf
Kotsiou OS, Zouridis S, Kosmopoulos M, Gourgoulianis KI. Impact of the financial crisis on COPD burden: Greece as a case study. European Respiratory Review Mar. 2018; 27(147): 170106. DOI: https://doi.org/10.1183/16000617.0106-2017
Nugmanova D, Feshchenko Y, Iashyna L, Gyrina O, Malynovska K, Mammadbayov E, Akhundova I, et al. The prevalence, burden and risk factors associated with chronic obstructive pulmonary disease in Commonwealth of Independent States (Ukraine, Kazakhstan and Azerbaijan): results of the CORE study. BMC Pulm Med. 2018;18(1): 26. doi: 10.1186/s12890-018-0589-5. DOI: https://doi.org/10.1186/s12890-018-0589-5
Calverley PM, Scott S. Is airway inflammation in chronic obstructive pulmonary disease (COPD) a risk factor for cardiovascular events? COPD. 2006;3(4): 233-42. doi: 10.1080/15412550600977544. DOI: https://doi.org/10.1080/15412550600977544
Caram LM, Ferrari R, Naves CR, Coelho LS, Vale SA, Tanni SE, GodoyI. Risk factors for cardiovascular disease in patients with COPD: mild-to-moderate COPD versus severe-to-very severe COPD. J Bras Pneumol. 2016;4 2(3): 179-84. DOI: https://doi.org/10.1590/S1806-37562015000000121
Prevent Cardiology and Rehabilitation Association [authored by: VM Kovalenko and others]. Preventive cardiology: implementation of international recommendations in Ukraine. [Превентивна кардіологія: імплементація міжнародних рекомендацій в Україні] Kyiv: MORION; 2015. Ukrainian.
Yin H, Yin S, Lin Q, Xu Y, Xu H, Liu T. Prevalence of comorbidities in chronic obstructive pulmonary disease patients: A meta-analysis. Medicine (Baltimore). 2017;96(19): e6836. DOI: https://doi.org/10.1097/MD.0000000000006836
Cavaillès A, Brinchault-Rabin G, Dixmier A, Goupil F, Gut-Gobert C, Marchand-Adam S, Meurice JC, et al. Comorbidities of COPD. European Respiratory Review. 2013;22: 454-75. DOI: https://doi.org/10.1183/09059180.00008612
Marushchak MI. [The role of reactive oxygen species in the development and progression of acute lung injury in experiment]. Med khim. 2012;1(50): 104-08. Ukrainian.
Wijnhoven HA, Kriegsman DM, Hesselink AE, de Haan M, Schellevis FG. The influence of co-morbidity on health-related quality of life in asthma and COPD patients. Respir Med. 2003;97(5): 468-75. DOI: https://doi.org/10.1053/rmed.2002.1463
Global Initiative for Chronic Obstructive Lung Disease (COLD). 2016; Available at: www.goldcopd.org.
Williams B, Mancia G, Spiering W, Rosei EA, Azizi M, Burnier M, Clement DL, et al. ESC/ESH Guidelines for the management of arterial hypertension. European Heart Journal. 2018;39(33): 3021-104. DOI: https://doi.org/10.1093/eurheartj/ehy339
Kostiuk VA, Potapovich AI, Kovaleva Zh. [A simple and sensitive method for the determination of superoxide dismutase based on the quercetin oxidation reaction]. Vopr med khim. 1990;32: 88-91. Russian.
Korolyuk MA, Ivanova AI, Mayorova IG. [Method for determination of catalase activity]. Lab delo. 1988;1: 16-19. Russian.
Harutyunyan AB, Dubinina EE, Zybina NN. Methods for assessing free radical oxidation and the antioxidant system of the body. [Методы оценки свободно-радикального окисления и антиоксидантной системы организма] Saint-Petersburg: Folio; 2000. Russian.
Ivchuk BB, Kovalchuk TA. [Oxidant-antioxidant system in chronic obstructive pulmonary disease of professional etiology]. Med i klin khim. 2019;21(2): 61-7. Ukrainian.
Tuder RM, Petrache I. Pathogenesis of chronic obstructive pulmonary disease. J Clin Invest. 2012;122(8): 2749-55. DOI: https://doi.org/10.1172/JCI60324
Lee JH. Pathogenesis of COPD. COPD Springer, Berlin, Heidelberg. 2017. DOI: https://doi.org/10.1007/978-3-662-47178-4_4
Maksiv CY, Marushchak MI. The role of oxidative stress in the development of chronic obstructive pulmonary diseases. Medical and Clinical Chemistry. 2019;1: 120-25.
Cavalcante AG, de Bruin PF. The role of oxidative stress in COPD: current concepts and perspectives. J Bras Pneumol. 2009; 35(12): 1227-37.
Hudyma AA, Marushchak MI, Habor HH, Kulitska MI. [Pathogenetic role of neutrophil granulocytes in the development of acute lung injury]. Bukov med visn. 2011;3(59): 82-5.
Domej W, Oettl K, Renner W. Oxidative stress and free radicals in COPD-implications and relevance for treatment. International journal of chronic obstructive pulmonary disease. 2014;9: 1207-24. doi :10.2147/COPD.S51226. DOI: https://doi.org/10.2147/COPD.S51226
Nadeem A, Raj HG, Chhabra SK. Increased oxidative stress and altered levels of antioxidants in chronic obstructive pulmonary disease. Inflammation. 2005;29(1): 23-32. DOI: https://doi.org/10.1007/s10753-006-8965-3
Regan EA, Mazur W, Meoni E, Toljamo T, Millar J, Vuopala K, Bowler RP, et al. Smoking and COPD increase sputum levels of extracellular superoxide dismutase. Free Radic Biol Med. 2011;51(3): 726-32. DOI: https://doi.org/10.1016/j.freeradbiomed.2011.05.008
Lemko OI. Some aspects of the etiology, pathogenesis and course of chronic obstructive pulmonary disease (Part II). Nauk visn Uzhhorod un-tu. 2013;1(46): 197-207. Ukrainian.
Menshchikova EB, Lankin VZ, Zenkov NK, Cooper IA, Circular NF, Trufakin VA. Oxidative stress. Prooxidants and antioxidants. [Окислительный стресс. Прооксиданты и антиоксиданты] Moscow: Slovo; 2006. Russian.
Brieger K, Schiavone S, Miller FJ, Krause KH. Reactive oxygen species: from health to disease. Swiss Med Wkly; 2012. DOI: https://doi.org/10.4414/smw.2012.13659
Limon-Pacheco J, Gonsebatt ME. The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stress. Mutation Research. 2009;674: 137-47. DOI: https://doi.org/10.1016/j.mrgentox.2008.09.015
Ahmad A, Shameem M, Husain Q. Relation of oxidant-antioxidant imbalance with disease progression in patients with asthma. Ann Thorac Med. 2012;7: 226-32. DOI: https://doi.org/10.4103/1817-1737.102182
Singh S, Verma SK, Kumar S, Ahmad MK, Nischal A, Singh SK, Dixit RK. Evaluation of oxidative stress and antioxidant status in chronic obstructive pulmonary disease. Scandinavian Journal of Immunology. 2017;85(2): 130-7. DOI: https://doi.org/10.1111/sji.12498
Kovaleva OM, Herasymchuk NM, Safarhalina-Kornilova NA. Level of 8-isoprostane and activity of superoxide dismutase and catalase in patients with hypertension with overweight and obesity against the background of combination antihypertensive therapy. Ekperement i klin med. 2013;2(59): 86-92. Ukrainian.
Pawluk H , Pawluk R, Robaczewska J, Kędziora-Kornatowska K, Kędziora J. Biomarkers of antioxidant status and lipid peroxidation in elderly patients with hypertension. Redox Report. 2017;22(6): 542-46. DOI: https://doi.org/10.1080/13510002.2017.1372072
Downloads
Published
How to Cite
Issue
Section
Accepted 2019-11-14
Published 2019-11-14
