CHANGES OF INDICATORS OF OXIDATIVE STRESS IN PATIENTS WITH ACID-DEPENDABLE DISEASES IN TREATMENT
Introduction. Gastroesophageal reflux disease (GERD) and peptic ulcer (PU) of the duodenum belonging to the group of acid-dependent diseases (ADD) remain the most common among gastroenterological pathologies. The main pathogenic component of the diseases, leading to the development of abrasions and relapses, is oxidative stress. The search for drugs that can effect the antioxidant defense systems in patients with ADD is actual.
The aim of the study – to investigate the state of oxidative homeostasis systems in patients with acid-dependent diseases during treatment using basic regimens and adding glutargin to the basic therapy.
ResearchMethods. 28 patients with GERD and 23 patients with GERD combined with PU duodenum were examined. Depending on the therapeutic regimens, each group is divided into 2 sub-groups: patients receiving basic treatment, and patients with treatment on traditional scheme with adding glutargin. Before and after the treatment, TBA-active products, activity of superoxide dismutase (SOD), catalase (Cat), glutathione peroxidase (GPO), glutathione reductase (GR), the content of reduced glutathione (GSH) were determined in the blood of the patients.
Result and Discussion. Analysis of the treatment data for patients with ADD indicates that the inclusion of glutargin in the basic therapy in patients with GERD and in patients with GERD combined with PU duodenum led to a significant decrease in TBA-active products both plasma and erythrocytes against the background of activation of SOD, Cat, indicators of the glutathione system. In patients who did not receive glutargin, the imbalance in the oxidative homeostasis system was not eliminated. The pharmacological effect of glutargin is related to the active ingredients that make up its composition, namely, L-arginine and L-glutamate. Antioxidant and membrane stabilizing properties of L-arginine are realized by means of NO-regulating system, L-glutamate activates the synthesis of glutathione.
Conclusions. The use of traditional basic therapy in patients with acid-dependent diseases did not eliminate manifestations of oxidative stress, as evidenced by the lack of reliable changes in the indices of lipid peroxidation systems and antioxidant protection. The inclusion of glutargin in the basic treatment of patients with gastroesophageal reflux disease and patients with gastroesophageal reflux disease combined with peptic ulcer of the duodenal ulcer allowed them to level out the depression of the enzyme antioxidant link, to raise recovered glutathione level and normalize lipoperoxidation processes parameters.
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