AGE-SPECIFIC FEATURES OF FATTY ACID COMPOSITION OF LIPID SERUM IN RATS WITH OBESITY UNDER THE INFLUENCE OF IODINE
Introduction. The article presents new data on the age-specific features of the fatty acid composition of the total serum lipids of white male rats with experimental alimentary obesity in the comparative effect of intragastric administration of biologically active iodine in the composition of Jodis-concentrate and inorganic iodine as a part of the Iodomarin.
The aim of the study – to investigate the comparative effect of biologically active iodine in the composition of Jodis-concentrate (JC) and inorganic iodine (II) as a part of Iodomarin (IM) on the fatty acid content of total serum lipids of white rats males with experimental alimentary obesity.
Research Methods. Experimental alimentary obesity have been investigated during 45 days on 48 Wistar white male rats of various ages. Animals were divided into 3 age groups, 16 animals in each: the group 1 – age 3 month; the group 2 – age 4 months; the group 3 – age 6.5 months. In each age group there were 4 subgroups: 1 – control, which was on the main diet at vivarium; subgroups 2, 3 and 4 – with experimental alimentary obesity. Besides it, animals of the group 4 received intragastrically intravenous iodine in the form of Iodine-concentrate and group 4 – inorganic iodine in the form of potassium iodide in Iodomarin drug. The fatty acid composition was determined by gas-liquid chromatography on a Hewlett Packard HP-6890 gas chromatograph with a flame-ionization detector equipped with a SP-2380 capillary column of 100 m in length (Supelco).
Results and Discussion. In serum of white rats in all age groups with EAO, an increase in the relative content of the SFA amount was noted, mainly due to stearic acid, compared with intact animals. In animals with EAO, who received Iodomarin and Jodis-concentrate results were better, comparing with animals in the subgroup 2.
Conclusions. Therefore, iodine has a positive effect on the fatty acid composition of lipid serum in rats with obesity.
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