Features of the damaging eff ect of chronic stress on rats’ heart of different sex


  • I. R. Mits
  • O. V. Denefil




We investigated the effect of chronic prenatal, postnatal stress and their combination on changes in lipid peroxidation, Na+,K+-ATPase, AST and ALT, the morphological structure of the rats’ heart of different sex. It was revealed the increase in lipid peroxidation products, increase in the activity of sodium-potassium ATP ase in males and the imbalance of its work in females, an increase of ALT in males. Most increase of necrosis’ amount was observed at postnatal stress in the heart of the males, combined – in females.


Abramov AV STATUS tolerance for Glucose in males, chronic transferred prenatalnыy stress / AV Abramov, M. Kolesnik, // MA Tyhonovskaya Zaporozh. honey. Zh. - 2004. - № 6. - P. 38-41.

Avtandylov G. System cardiomyocyte-capillaries human heart in norm and at Ostrom ynfarkte myocardium (stereometrycheskoe Study) / GG Avtandylov, TA Hevondyan // Cardiology. - 1979 - 19, № 10. - P. 79-83.

Denefil AV Influence on autonomous Inderal Balance heart rate of rats with adrenalinic damage to the heart, depending on the different types of weather / AV // Denefil Halytsia. doctor. Visn. - 2008. - № 3. - S. 20-22.

Ostapchenko L. Biological membranes: Methods studies of the structure and function: teach. guidances. / LI Ostapchenko, IV Mikhailik. - K: Publishing Printing Center "Kyiv University", 2006. - S. 163-165.

Parswani M. J. Mindfulness-based stress reduction program in coronary heart disease: A randomized control trial / M. J. Parswani, M. P. Sharma, S. Iyengar // Int. J. Yoga. - 2013 - 6 (2). - P. 111-117.

Physiological responses to emotional excitement in healthy subjects and patients with coronary artery disease / O. P. Piira, J. A. Miettinen, A. J. Hautala [et al.] / Auton. Neurosci. - 2013 - 177 (2). - P. 280-285.

Prenatal maternal bereavement and congenital heart defects in offspring: a registry-based study / J. L. Zhu, J. Olsen, H. T. Sorensen [et al.] // Pediatrics. - 2013 - 131 (4). - P. 1225-1230.

Sex-specific effects of prenatal stress on glucose homoeostasis and peripheral metabolism in rats / P. J. Brunton, K. M. Sullivan, D. Kerrigan [et al.] // J. Endocrinol. - 2013 - 217 (2). - P. 161-173.

Sex-specific interaction effects of age, occupational status, and workplace stress on psychiatric symptoms and allostatic load among healthy Montreal workers / R. P. Juster, D. S. Moskowitz, J. Lavoie, B. D'Antono / Stress. - 2013 - 16 (6). - P. 616-629.

The relationship of chronic and momentary work stress to cardiac reactivity in female managers: feasibility of a smart phone-assisted assessment system / M. A. Lumley, W. Shi, C. Wiholm [et al.] // Psychosom. Med. - 2014 - 76 (7). - P. 512-518.




How to Cite

Mits, I. R., & Denefil, O. V. (2016). Features of the damaging eff ect of chronic stress on rats’ heart of different sex. Medical and Clinical Chemistry, (1), 80–84. https://doi.org/10.11603/mcch.2410-681X.2016.v0.i1.6277