THE ROLE OF MOLECULAR HYDROGEN IN NEURODEGENERATE PROCESSES (LITERATURE REVIEW)
DOI:
https://doi.org/10.11603/mcch.2410-681X.2024.i4.15116Keywords:
molecular hydrogen; oxidative stress; neurodegenerative diseases; hydrogenated water; nitric oxide.Abstract
Introduction. The beneficial effects of molecular hydrogen (H2, hydrogen) have been confirmed in many disease models and human studies over the past decade, and the number of peer-reviewed articles on hydrogen biomedicine has exceeded 800 since 2005. More than two dozen clinical trials have been conducted to assess the therapeutic potential of H2. It has been demonstrated that the use of additional molecular hydrogen improves a number of clinical signs in various diseases. These include neuromuscular, neurodegenerative and mental diseases, cardiovascular diseases, metabolic syndrome and diabetes, acute soft tissue injuries and skin pathologies, kidney disease, inflammatory diseases and cancer. Research is currently underway on the feasibility of using it for Covid-19, as well as for improving the endurance of athletes, and there are even studies claiming that hydrogen water can slow down the aging of the human body. The aim of the study. To highlight the general characteristics and therapeutic properties of molecular hydrogen, the mechanisms of interaction with the body of hydrogen and its compounds, strategies for administration into the body, as well as the feasibility of using it in neurodegenerative disorders on the example of specific diseases (Parkinson’s disease, Alzheimer’s disease, multiple sclerosis and vascular dementia). Conclusions. The analysis of the literature showed that molecular hydrogen and its compounds (hydrogen sulfide and complex therapy in combination with nitric oxide) have a pronounced antioxidant and neuroprotective effect, which makes it advisable to use them in adjuvant therapy for neurodegenerative diseases.
References
Breathing Hydrogen-Oxygen Mixture Decreases Inspiratory Effort in Patients with Tracheal Stenosis / Zi-Qing Zhou et al. Respiration. 2018. Vol. 97. № 1. P. 42–51. https://doi.org/10.1159/000492031.
Роль молекулярного водню та оксиду азоту в патогенезі Covid-19 / О. С. Покотило та ін. Medical and Clinical Chemistry. 2021. № 1. С. 93–100. https://doi. org/10.11603/mcch.2410-681x.2021.i1.12119.
Ostojic S. M. Targeting molecular hydrogen to mitochondria: Barriers and gateways. Pharmacological Research. 2015. Vol. 94. P. 51–53. https://doi.org/10.1016/j.phrs.2015.02.004.
Redox Effects of Molecular Hydrogen and Its Therapeutic Efficacy in the Treatment of Neurodegenerative Diseases / Md Habibur Rahman et al. Processes. 2021. Vol. 9. № 2. P. 308. https://doi. org/10.3390/pr9020308.
Effects of 7-day intake of hydrogen-rich water on physical performance of trained and untrained subjects / Rafael Timón et al. Biology of Sport. 2020. https://doi.org/10.5114/biolsport.2020.98625.
The effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over: A randomized controlled pilot trial / Dragana Zanini et al. Experimental Gerontology. 2021. Vol. 155. P. 111574. https://doi. org/10.1016/j.exger.2021.111574.
Hydrogen Sulphide-Based Therapeutics for Neurological Conditions: Perspectives and Challenges / Amir H. Sharif et al. Neurochemical Research. 2023. https://doi.org/10.1007/s11064-023-03887-y.
Munteanu C. Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis : A Comprehensive One-Year Review / Constantin Munteanu et al. Antioxidants. 2023. Vol. 12. № 9. P. 1737. https://doi.org/10.3390/antiox12091737.
Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis / Yan Tian et al. Frontiers in Physiology. 2021. Vol. 12. https://doi.org/10.3389/fphys.2021.789507.
Effects of hydrogen-rich water prepared by alternating-current-electrolysis on antioxidant activity, DNA oxidative injuries, and diabetes-related markers / R. Asada et al. Medical Gas Research. 2020. Vol. 10. № 3. P. 0. https://doi.org/10.4103/2045-9912.296041.
Oral Administration of Si-Based Agent Attenuates Oxidative Stress and Ischemia-Reperfusion Injury in a Rat Model: A Novel Hydrogen Administration Method / M. Kawamura et al. Frontiers in Medicine. 2020. Vol. 7. https://doi.org/10.3389/fmed.2020.00095.
Estimation of the hydrogen concentration in rat tissue using an airtight tube following the administration of hydrogen via various routes / C. Liu et al. Scientific Reports. 2014. Vol. 4. № 1. https://doi.org/10.1038/ srep05485.
Fu Z., Zhang J. Molecular hydrogen is a promising therapeutic agent for pulmonary disease. Journal of Zhejiang University-SCIENCE B. 2022. Vol. 23. № 2. P. 102–122. https://doi.org/10.1631/jzus.b2100420.
Molecular hydrogen: A potential radioprotective agent / Q. Hu et al. Biomedicine & Pharmacotherapy. 2020. Vol. 130. P. 110589. https://doi.org/10.1016/ j.biopha.2020.110589.
Potential Cytoprotective Activity of Ozone Therapy in SARS-CoV-2/COVID-19 / G. Martinez- Sanchez et al. Antioxidants. 2020. Vol. 9. № 5. P. 389. https://doi.org/10.3390/antiox9050389.
Pharmacokinetics of a single inhalation of hydrogen gas in pigs / M. Sano et al. PLOS ONE. 2020. Vol. 15. № 6. P. e0234626. https://doi.org/10.1371/ journal.pone.0234626.
Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents / S. Sobue et al. Molecular and Cellular Biochemistry. 2015. Vol. 403. № № 1–2. P. 231–241. https://doi.org/10.1007/s11010-015-2353-y.
Beneficial biological effects and the underlying mechanisms of molecular hydrogen – comprehensive review of 321 original articles / M. Ichihara et al. Medical Gas Research. 2015. Vol. 5. № 1. https://doi.org/10.1186/ s13618-015-0035-1.
Redox metabolism: ROS as specific molecular regulators of cell signaling and function / Claudia Lennicke et al. Molecular Cell. 2021. Vol. 81. № 18. P. 3691–3707. https://doi.org/10.1016/j.molcel.2021.08.018.
Analysis of the effect of health insurance on health care utilization in Rwanda: a secondary data analysis of Rwandan integration living condition survey 2016-2017 (EICV 5) / Roger Muremyi et al. PAMJ – One Health. 2021. Vol. 4. https://doi.org/10.11604/ pamj-oh.2021.4.10.25256.
Hydrogen therapy: recent advances and emerging materials / Zheng Jiang et al. Biomaterials Science. 2024. https://doi.org/10.1039/d4bm00446a.
The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Metabolic Disorders Clinical Trials : A Systematic Review and Meta-analysis / Hamid Jamialahmadi et al. International Journal of Endocrinology and Metabolism. 2024. Vol. 22. № 3. https://doi.org/10.5812/ijem-148600.
A Systematic Review of Molecular Hydrogen Therapy in Cancer Management / Muhammad Nooraiman Zufayri Mohd Noor et al. Asian Pacific Journal of Cancer Prevention. 2023. Vol. 24. № 1. P. 37–47. https://doi.org/10.31557/apjcp.2023.24.1.37.
Oxidative Stress and Inflammation: What Polyphenols Can Do for Us? / Tarique Hussain et al. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016. P. 1–9. https://doi.org/10.1155/2016/7432797.
Intake of Molecular Hydrogen in Drinking Water Increases Membrane Transporters, p-Glycoprotein, and Multidrug Resistance-Associated Protein 2 without Affecting Xenobiotic-Metabolizing Enzymes in Rat Liver / Hsien-Tsung Yao et al. Molecules. 2019. Vol. 24. № 14. P. 2627. https://doi.org/10.3390/ molecules24142627.
Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial / Minju Sim et al. Scientific Reports. 2020. Vol. 10. № 1. https://doi.org/10.1038/s41598-020-68930-2.
Molecular hydrogen: a preventive and therapeutic medical gas for various diseases / Li Ge et al. Oncotarget. 2017. Vol. 8. № 60. P. 102653–102673. https://doi.org/10.18632/oncotarget.21130.
The Impact of Hydrogen Inhalation Therapy on Blood Reactive Oxygen Species Levels: A Randomized Controlled Study / Mohamed Chair et al. Free Radical Biology and Medicine. 2024. https://doi.org/10.1016/ j.freeradbiomed.2024.07.010.
Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications / Zewen Liu et al. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017. P. 1–11. https:// doi.org/10.1155/2017/2525967.
Neuroprotective effects of hydrogen inhalation in an experimental rat intracerebral hemorrhage model / Kyu-Sun Choi et al. Brain Research Bulletin. 2018. Vol. 142. P. 122–128. https://doi.org/10.1016/ j.brainresbull.2018.07.006.
Hydrogen protects against chronic intermittent hypoxia induced renal dysfunction by promoting autophagy and alleviating apoptosis / Peng Guan et al. Life Sciences. 2019. Vol. 225. P. 46–54. https://doi.org/10.1016/j.lfs.2019.04.005.
A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress / Tyler W. LeBaron et al. Molecules. 2019. Vol. 24. № 11. P. 2076. https://doi.org/10.3390/molecules24112076.
Cuadrado A. Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy / Antonio Cuadrado et al. Redox Biology. 2018. Vol. 14. P. 522–534. https://doi.org/10.1016/ j.redox.2017.10.010.
Autophagy and Akt/CREB signalling play an important role in the neuroprotective effect of nimodipine in a rat model of vascular dementia / Ming Hu et al. Behavioural Brain Research. 2017. Vol. 325. P. 79–86. https://doi.org/10.1016/j.bbr.2016.11.053.
FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat model of vascular dementia / Xin Jiang et al. Behavioural Brain Research. 2019. Vol. 356. P. 98–106. https://doi.org/10.1016/j.bbr.2018.05.023.
Neuroprotective effects of hydrogen sulfide in Parkinson’s disease / Haitao Shen et al. Medical Gas Research. 2023. P. 0. https://doi.org/10.4103/2045-9912.385945.
Role of Gasotransmitters in Oxidative Stresses, Neuroinflammation, and Neuronal Repair / Ulfuara Shefa et al. BioMed Research International. 2017. Vol. 2017. P. 1–15. https://doi.org/10.1155/2017/1689341.
Oxidative Stress in Neurodegenerative Diseases / Ewa Niedzielska et al. Molecular Neurobiology. 2015. Vol. 53. № 6. P. 4094–4125. https://doi.org/10.1007/ s12035-015-9337-5.
Sustained release of bioactive hydrogen by Pd hydride nanoparticles overcomes Alzheimer’s disease / Lei Zhang et al. Biomaterials. 2019. Vol. 197. P. 393–404. https://doi.org/10.1016/j.biomaterials.2019.01.037.
New Insights in the Mechanisms of Impaired Redox Signaling and its Interplay with Inflammation and Immunity in Multiple Sclerosis / D. Michalickova et al. Physiological Research. 2020. P. 1–19. https://doi. org/10.33549/physiolres.934276.
Diabetic Neuropathy: A Position Statement by the American Diabetes Association / Rodica Pop-Busui et al. Diabetes Care. 2016. Vol. 40. № 1. P. 136–154. https://doi.org/10.2337/dc16-2042.
Hydrogen sulfide is neuroprotective in Alzheimer’s disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation / Daniel Giovinazzo et al. Proceedings of the National Academy of Sciences. 2021. Т. 118. № 4. P. e2017225118. https://doi.org/10.1073/pnas.2017225118.
The Role of Oxidative Stress and Antioxidants in Liver Diseases / Sha Li et al. International Journal of Molecular Sciences. 2015. Vol. 16. № 11. P. 26087–26124. https://doi.org/10.3390/ijms161125942.
Protective effect of hydrogen sulfide on oxidative stress-induced neurodegenerative diseases / NaYoung Jeong et al. Neural Regeneration Research. 2020. Vol. 15. № 2. P. 232. https://doi.org/10.4103/1673-5374.265543.
Kumar Mohit, Sandhir Rajat. Hydrogen Sulfide in Physiological and Pathological Mechanisms in Brain. CNS & Neurological Disorders. Drug Targets. 2018. Vol. 17. № 9. P. 654–670. https://doi.org/10.2174/187152731766 6180605072018.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Medical and Clinical Chemistry
This work is licensed under a Creative Commons Attribution 4.0 International License.
