THE CONTENT OF BONE METABOLISM MARKERS IN BLOOD AND URINE IN PATIENTS WITH SYSTEMIC OSTEOPOROSIS BEFORE THE SURGICAL STAGE OF DENTAL IMPLANTATION
DOI:
https://doi.org/10.11603/mcch.2410-681X.2023.i2.13973Keywords:
systemic osteoporosis, alkaline phosphatase, tartrate-resistant acid phosphatase, oxyprolineAbstract
Introduction. Systemic osteoporosis is a disease of the skeletal system characterized by a decrease in the mass and quality of skeletal bones. This disease can affect the results of dental implantation, which is currently one of the most effective methods of restoring lost teeth and provides patients with the return of function and aesthetics of their damaged teeth. One of the key factors affecting the success of dental implants is the condition of the bone tissue. Bone metabolism markers can help to establish the exact condition of a patient's bone tissue and predict the success of dental implants in the future.
The aim of the study – to determine and establish the content of bone metabolism markers in patients with systemic osteoporosis who required dental implantation.
Research Methods. The content of bone metabolism markers in blood and urine was determined in 87 patients who needed dental implants. Alkaline phosphatase (ALP) was determined using a heterogeneous enzyme-linked immunosorbent assay (ELISA). The activity of the ELISA was measured using a Spektrum Series 2 autoanalyzer (Abbott, USA). TRACP activity in the blood of patients was determined by enzyme-linked immunosorbent assay using the Bone TRACP Assay kit. The method for determining the content of oxyproline in urine in patients of the study groups was based on the oxidation of hydroxyproline to pyrrole by hydrogen peroxide in an alkaline medium in the presence of copper ions.
Results and Discussion. As a result of the studies, it was found that the most pronounced imbalance of bone remodeling markers was found in women with osteoporosis of group I, and a slightly less pronounced trend in men with osteoporosis in relation to biochemical parameters studied in individuals without bone mineral density disorders. Thus, in women with osteoporosis, an increase in TRACP activity was observed by 11.19 %, urinary oxyproline level by 31.75 %, against a decrease in alkaline phosphatase activity by 3.0 times, p, p1<0.01.
Conclusions. Consequently, metabolic disorders in systemic osteoporosis adversely affect the structures of the oral cavity, which may be the reason for the low efficiency of dental implants and indicate the need to improve orthopedic and surgical treatment by developing adequate gender-specific osteotropic therapy.
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