CHANGES OF VALUES OF HOMEOSTASIS SYSTEM IN PREGNANT WOMEN AFTER CORONAVIRUS INFECTION

Authors

  • N. V. Adamchuk DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY
  • A. V. Kolesnyk DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY
  • V. G. Korniienko DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY
  • O. P. Myalyuk RIVNE MEDICAL ACADEMY
  • L. R. Korobko RIVNE MEDICAL ACADEMY
  • M. I. Marushchak I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY

DOI:

https://doi.org/10.11603/mcch.2410-681X.2023.i2.13690

Keywords:

hemostasis, pregnancy, post-covid syndrome, hypercoagulation, hypocoagulation, fibrinogen, platelets

Abstract

Introduction. Thrombotic microangiopathy in combination with hypercoagulable syndrome as a result of a previous coronavirus infection can significantly increase the risk of pregnancy complications such as pre-eclampsia, placental insufficiency, fetal hypoxia and, as a result, lead to a delay in intrauterine development of the fetus.

The aim of the study – to investigate the effect of the transmitted coronavirus infection on the parameters of the hemostasis system in different trimesters of pregnancy.

Research Methods. 58 patients aged 20–36 years, who had a desired pregnancy 2–4 months after suffering a coronavirus infection, were examined. Pregnant women were divided into three groups depending on the severity of the disease: mild (n=15), moderate (n=25) and severe (n=18). Determination of hemostasis system indicators was carried out in the department of the clinical and diagnostic laboratory of the Rivne Central City Hospital.

Results and Discussion. One of the directions of the pathological manifestation of coronavirus infection is the effect on the microcirculatory channel and the hemostasis system. The maximum increase in platelets was observed in the third trimester. It should be noted that the sum of active forms of platelets and the index of platelet aggregation during the entire observation period were the highest in the group of women who suffered from severe coronavirus infection. In the control group, the share of patients with disorders of fibrinogen activity was 6.4 %, in the first group – 7.3 %, in the second – 8.8 %, and in the third – 21.4 %. The highest aggregation of platelets, which characterizes the density of the clot and is determined by the level of platelets and fibrinogen, was also observed in pregnant women with a severe course of coronavirus infection and was 14.7 % (р≤0.01) higher compared to the control group. It should be noted that the highest D-dimer level was maintained throughout pregnancy in the group of women who suffered from severe coronavirus infection: in the first trimester it was 11.5 % higher (р≤0.01) compared to the level of women in the control group; in the second trimester – by 17.7 (р≤0.01), in the third – by 67.2 (р≤0.01), respectively.

Conclusions. In women who had a coronavirus infection, disorders in the hemostasis system persist 4 months after recovery in the absence of clinical symptoms. These violations are more pronounced in the case of a severe course of the disease, but no direct relationship between them was found.

References

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Published

2023-07-11

How to Cite

Adamchuk, N. V., Kolesnyk, A. V., Korniienko, V. G., Myalyuk, O. P., Korobko, L. R., & Marushchak, M. I. (2023). CHANGES OF VALUES OF HOMEOSTASIS SYSTEM IN PREGNANT WOMEN AFTER CORONAVIRUS INFECTION. Medical and Clinical Chemistry, (2), 39–43. https://doi.org/10.11603/mcch.2410-681X.2023.i2.13690

Issue

No. 2 (2023)

Section

ORIGINAL INVESTIGATIONS

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