HORMONAL PROFILE IN WOMEN WITH REPRODUCTIVE FAILS AND METABOLIC DISORDERS
DOI:
https://doi.org/10.11603/mcch.2410-681X.2022.i4.13571Keywords:
infertility, assisted reproductive technologies, in vitro fertilization, polycystic ovary syndrome, hormones, progesterone, estradiol, metabolic syndrome, obesityAbstract
Introduction. Only the full interaction of the hypothalamic-pituitary-gonadal axis provides the normal functioning of the reproductive system. Hormonal regulation disorders are observed in women of reproductive age with polycystic ovary syndrome (PCOS). Infertility and reproductive losses are characteristic of women with PCOS. Key links of pathogenesis, which are directly related to the occurrence of hormonal imbalance, are also important for understanding right treatment approaches. These are the current issues for further research.
The aim of the study – to determine the levels of sex hormones in women with infertility against the background of PCOS and its correlation with the body mass index.
Materials and Methods. The clinical data analysis of patients’ cards was performed and the level of hormones of the reproductive system was determined. Patients were divided into two groups: with normal body weight and with obesity. In this case, 4 subgroups were identified in the group of studied groups based on the BMI.
Results and Discussion. The analysis of associations between the levels of sex hormones and BMI showed that the LH/FSH ratio and the concentration of FSH, prolactin, estradiol and testosterone depended on body mass. It was established that BMI has a weak inverse relationship with the level of FSH, as well as a direct relationship with the ratio of LH/FSH and the concentration of LH, prolactin, estradiol and testosterone.
Conclusions. Women with infertility on the background of PCOS are characterized by hormonal imbalance (increased levels of anti-Müllerian and luteinizing hormones, estradiol and testosterone, decreased level of FSH).
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