INVESTIGATION OF HEPATOPROTECTIVE ACTIVITY OF EXTRACTS OF ERYNGIUM PLANUM L.
DOI:
https://doi.org/10.11603/mcch.2410-681X.2022.i1.13032Keywords:
Eryngium planum, hepatoprotective activity, herbal extractsAbstract
Introduction. The liver is a vital organ that provides many functions in the human body. Alcohol, unhealthy foods, long-term medication, infectious or autoimmune diseases can cause serious diseases of the hepatobiliary system, so it is important to develop and study new phytopreparations with hepatoprotective activity.
The aim of the study – investigation of hepatoprotective activity of Eryngium planum L.
Research Methods. The study of hepatoprotective activity of extracts of Eryngium planum L. was performed on white male rats weighing 180–250 g on the model of acute carbon tetrachloride hepatitis according to the Stefanov's method. “Silibor” is a hepatoprotector which was used as a comparison drug.
Results and Discussion. Administration of carbon tetrachloride to experimental animals resulted in acute liver damage. In the group of untreated animals, liver damage was accompanied by a significant increase in the activity of ALT, AST, alkaline phosphatase and TBA-active products. Biochemical parameters of blood serum and liver homogenate in the group of animals that received extracts of Eryngium planum L. indicate less liver damage compared to the group of animals that did not receive treatment.
Conclusions. Extracts of Eryngium planum L. show hepatoprotective activity in acute liver disease with carbon tetrachloride.
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