OXIDANT AND ANTIOXIDANT SYSTEMS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE OCCUPATIONAL ETIOLOGY
Introduction. The main reason for the failure of the mechanisms of specific and non-specific defense of the body in many diseases and pathological conditions is an imbalance in the system of prooxidants-antioxidants. A significant imbalance in this system is accompanied by the development of oxidative stress with its pathological components. The presence of oxidative stress was observed in a number of physiological and many pathological states. There is no exception and such a common disease among the mining industry workers as chronic obstructive pulmonary disease of occupational etiology.
The aim of the study – to evaluate the features and direction of shifts of individual indicators of the oxidative-antioxidant system in chronic obstructive pulmonary disease of occupational etiology.
Research Methods. The results of venous blood studies of 170 workers in the mining industry in patients with chronic obstructive pulmonary disease with varying degrees of severity are analyzed. Among the patients, 60 people had stage II, 56 people had stage III disease, and 54 practically healthy individuals formed the control group. The state of lipid oxidation in the serum of patients was assessed by the content of TBA-active products of their peroxidation. The state of the antioxidant protection system was assessed by the content or activity of a number of primary protection components – superoxide dismutase, catalase, glutathione peroxidase, ceruloplasmin, and non-enzymatic low molecular weight compounds.
Results and Discussion. An increase in the level of TBA-active products and a decrease in the total antioxidant activity of plasma indicates a deepening of oxidative stress. In chronic obstructive pulmonary disease of occupational etiology, the protective capabilities of the antioxidant defense system are depleted, and the balance between generation and elimination of active oxygen radicals is disturbed. Hence, the lack of antioxidant protection is obviously one of the factors provoking a severe course and progression of chronic obstructive pulmonary disease of occupational etiology.
Conclusions. During the course of chronic obstructive pulmonary disease of occupational etiology of varying degrees of severity, lipid peroxidation processes are enhanced. These violations occur against the background of inhibition of the antioxidant defense system. This is accompanied by a disorder in the glutathione system.
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