SURGICAL CORRECTION OF VAGINAL APLASIA IN PATIENTS WITH MAYER – ROKITANSKY – KÜSTER – HAUSER SYNDROME
DOI:
https://doi.org/10.11603/24116-4944.2026.1.16379Keywords:
vaginal aplasia, congenital anomalies of the female reproductive organs, Mayer – Rokitansky – Küster – Hauser syndrome (MRKH), colpoplasty, surgical treatment, reconstructive gynecology, amenorrhea, sexual dysfunctionAbstract
The aim of the study – to evaluate the effectiveness of laparoscopic methods for surgical correction of vaginal aplasia in patients with Mayer – Rokitansky – Küster – Hauser syndrome by assessing immediate and long-term surgical outcomes and female sexual function.
Materials and Methods. An analysis was conducted of the examination and treatment results of 32 patients with Mayer – Rokitansky – Küster – Hauser (MRKH) syndrome. The control group consisted of 20 healthy women. All patients underwent surgical neovaginal reconstruction using laparoscopic techniques: Group 1 (19 patients) – peritoneal colpoplasty (modified Davidov technique), Group 2 (13 patients) – sigmoid colpoplasty. Preoperative examination included clinical, ultrasound, and, when indicated, magnetic resonance imaging of the pelvic organs. Intraoperative parameters, postoperative complications, anatomical and functional parameters, and the long-term sexual function index were evaluated.
Results and Discussion. In patients from both study groups, a satisfactory anatomical outcome was achieved with the formation of a functionally intact neovagina. There were no significant differences in the number and range of postoperative complications, the amount of blood loss, postoperative fever and low-grade fever, pain syndrome, duration of surgery, or length of hospital stay between the main group and the comparison group. The average length of the formed neovagina after surgery was (8.31±0.14) cm in Group 1 and (8.44±0.18) cm in Group 2 (p>0.05). The sexual function assessment index 12 months after surgery showed comparable results with the control group: (26.66±0.28) points in Group 1 versus (26.78±0.31) points in Group 2 and (27.28±0.24) points in the control group.
Conclusions. Sigmoid and peritoneal colpoplasty ensure the formation of a fully functional neovagina with good early and late postoperative anatomical and functional outcomes, which show no significant differences between the compared groups. An individualized choice of surgical reconstruction method for Mayer – Rokitansky – Küster – Hauser syndrome contributes to the effective elimination of sexual dysfunction.
References
1. Herlin, M. K., Petersen, M. B., & Brännström, M. (2020). Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome: A comprehensive update. Orphanet Journal of Rare Diseases, 15(1), 214. https://doi.org/10.1186/s13023-020-01491-9
2. Novoa, C. C. T., Leite, M. T. C., & Sartori, M. G. F. (2025). Mayer-Rokitansky-Küster-Hauser syndrome. Revista Brasileira de Ginecologia e Obstetrícia, 47, e-FPS4. https://doi.org/10.61622/rbgo/2025FPS4
3. Herlin, M. K. (2024). Genetics of Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome: Advancements and implications. Frontiers in Endocrinology, 15, 1368990. https://doi.org/10.3389/fendo.2024.1368990
4. Zhang, C., Zhang, F., Wang, X., & Zhang, S. (2022). Retrospective comparative cohort study of neovagina creation by modified Vecchietti laparoendoscopic single-site surgery for Mayer-Rokitansky-Küster-Hauser syndrome. Annals of Translational Medicine, 10(19), 1063. https://doi.org/10.21037/atm-22-4360
5. Martens, L., Tannenbaum, L., Van Kuijk, S. M. J., Notten, K. J. B., & Kluivers, K. B. (2024). Laparoscopic Davydov versus laparoscopic Vecchietti neovaginoplasty in women with Mayer-Rokitansky-Küster-Hauser syndrome: A systematic review and meta-analysis. Fertility and Sterility, 121(4), 679–692. https://doi.org/10.1016/j.fertnstert.2023.12.015
6. Wang, Y. Y., Duan, H., Zhang, X. N., & Wang, S. (2021). Neovagina creation: A novel improved laparoscopic Vecchietti procedure in patients with Mayer-Rokitansky-Küster-Hauser syndrome. Journal of Minimally Invasive Gynecology, 28(1), 82–92. https://doi.org/10.1016/j.jmig.2020.04.006
7. Tlais, M., Khalil, L. M., Haddad, K., Obeid, N., El Fawal, K., Hawi, J., ... & Fakih, G. (2025). The role of laparoscopic surgery in gynecological congenital anomalies. Maedica, 20(4), 840–850. https://doi.org/10.26574/maedica.2025.20.4.840
8. Esencan, E., St. Martin, B., Harmanli, O., & Vash-Margita, A. (2023). Surgical correction of vaginal agenesis via modified laparoscopic Vecchietti procedure. Journal of Pediatric and Adolescent Gynecology, 36(6), 556–559. https://doi.org/10.1016/j.jpag.2023.06.004
9. Medvediev, M., Spesyvtsev, D., & Pokrovenko, D. (2021). A case of neovagina surgical creation using the uterine cervix remnant in a patient with Mayer-Rokitansky-Küster-Hauser syndrome. Fertility and Sterility, 116(5), 1420–1422. https://doi.org/10.1016/j.fertnstert.2021.06.030
10. Imaeda, K., Kobayashi, Y., Nakamura, K., Hayashi, S., Morisada, T., Banno, K., & Aoki, D. (2021). Usefulness of endoscopy for female genital plastic surgery: A series of four cases with genital malformations. American Journal of Case Reports, 22, e934363. https://doi.org/10.12659/AJCR.934363
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Igor Gladchuk, Hanna Shytova, Natalia Rozhkovska
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish in this journal agree to the following terms:
1. The authors reserve the right to authorship of the work and pass the journal right of first publication of this work is licensed under a Creative Commons Attribution License, which allows others to freely distribute the work published with reference to the authors of the original work and the first publication of this magazine.
2. Authors are entitled to enter into a separate agreement on additional non-exclusive distribution of work in the form in which it was published in the magazine (eg work place in the electronic repository institution or publish monographs in part), provided that the reference to the first publication of this magazine.
3. Policy magazine allows and encourages authors placement on the Internet (eg, in storage facilities or on personal websites) manuscript of how to submit the manuscript to the editor and during his editorial processing, since it contributes to productive scientific discussion and positive impact on the efficiency and dynamics of citing published work (see. The Effect of Open Access).
