OXYTOCIN: EFFECTS AND RISKS IN PREGNANT WOMEN

Authors

DOI:

https://doi.org/10.11603/24116-4944.2025.2.15796

Keywords:

oxytocin, pregnancy, puerpera, labor, fetus, newborn

Abstract

The aim of the study – to analyze the literature data on the properties of oxytocin, a drug widely used in obstetric and gynecological practice. Its role as a neurotransmitter has been demonstrated, exerting a significant influence on almost all organs and systems, as well as on social, behavioral, and mental responses of individuals. In obstetric practice, oxytocin is prescribed according to established protocols; however, many details contradict the information provided in the drug instructions. Both clinical practice and literature data indicate the necessity of further research regarding minimal effective doses, routes of administration, and its effects on the mother and fetus.

Conclusions. The need to introduce the issue of finding optimal oxytocin regimens that will minimize the risks of hyperstimulation while ensuring the effectiveness of therapy.

Author Biographies

  • V. F. Nagorna, Odessa National Medical University

    Professor of the Department of Obstetrics and Gynecology

  • T. A. Kulish, Odessa National Medical University

    obstetrician-gynecologist

  • R. G. Bichevska, Odessa National Medical University

    Assistant Professor of the Department of Obstetrics and Gynecology

References

1. Dale, H.H. (1909). The action of extracts of the pituitary body. Biochemical Journal, 4(9), 427–447. https://doi.org/10.1042/bj0040427

2. Grigor’eva, M.E., & Golubeva, M.G. (2010). Oxytocin: Structure, synthesis, receptors, and basic effects. Neurochemical Journal, 4(2), 75–83.

3. Du Vigneaud, V., Ressler, C., & Trippett, S. (1953). The sequence of amino acids in oxytocin, with a proposal for the structure of oxytocin. Journal of Biological Chemistry, 205(2), 949–957.

4. Arrowsmith, S., & Wray, S. (2014). Oxytocin: Its mechanism of action and receptor signalling in the myometrium. Journal of Neuroendocrinology, 26(6), 356–369. https://doi.org/10.1111/jne.12154

5. Chevaleyre, V., Dayanithi, G., Moos, F., & Desarmenien, M. (2000). Developmental regulation of a local positive autocontrol of supraoptic neurons. Journal of Neuroscience, 20(15), 5813–5819.

6. Ludwig, M. (1998). Dendritic release of vasopressin and oxytocin. Journal of Neuroendocrinology, 10, 881–895. https://doi.org/10.1046/j.1365-2826.1998.00375.x

7. Vrachnis, N., Malamas, F.M., Sifakis, S., Deligeoroglou, E., & Iliodromiti, Z. (2011). The oxytocin–oxytocin receptor system and its antagonists as tocolytic agents. International Journal of Endocrinology, 2011, Article ID 350546. https://doi.org/10.1155/2011/350546

8. Norbert, C.J., & Heck, A.J.R. (2010). The effect of oxytocin and an oxytocin antagonist on the human myometrial proteome. Reproductive Sciences, 17, 40–46. https://doi.org/10.1177/1933719109348220

9. Plevrakis, I., Calmagirand, C., & Pontonnier, G. (1990). Oxytocin biosynthesis in serum-free cultures of human granulosa cells. Journal of Endocrinology, 124, 5–11. https://doi.org/10.1677/joe.0.1240005

10. Saller, S.L., Kunz, G.A., & Dissen, R.S. (2010). Oxytocin receptors in the primate ovary: Molecular identity and link to apoptosis in human granulosa cells. Human Reproduction, 25(4), 969–976. https://doi.org/10.1093/humrep/deq012

11. Zeeman, G.G., Khan-Dawood, F.S., & Dawood, M.Y. (1997). Oxytocin and its receptor in pregnancy and parturition: Current concepts and clinical implications. Obstetrics & Gynecology, 89(5 Pt 2), 873–883. https://doi.org/10.1016/S0029-7844(97)00056-2

12. Rekawiecki, R., Nowocin, A., & Kotwica, J. (2010). Relationship between concentrations of progesterone, oxytocin, noradrenaline, gene expression and protein level for their receptors in corpus luteum during estrous cycle in the cow. Prostaglandins & Other Lipid Mediators, 92, 13–18. https://doi.org/10.1016/j.prostaglandins.2010.04.003

13. Gordon, I., Vander Wyk, B.C., Bennett, R.H., et al. (2013). Oxytocin enhances brain function in children with autism. Proceedings of the National Academy of Sciences of the United States of America, 110(52), 20953–20958. https://doi.org/10.1073/pnas.1312857110

14. Watanabe, T., Abe, O., Kuwabara, H., et al. (2014). Mitigation of sociocommunicational deficits of autism through oxytocin-induced recovery of medial prefrontal activity: A randomized trial. JAMA Psychiatry, 71(2), 166–175. https://doi.org/10.1001/jamapsychiatry.2013.3181

15. Smith, J., et al. (2021). The role of oxytocin in the inflammatory response in endometriosis. Journal of Reproductive Immunology, 143, 103245. https://doi.org/10.1016/j.jri.2020.103245

16. Jones, L., et al. (2022). Oxytocin promotes angiogenesis in endometrial tissue through VEGF activation. Journal of Endocrinology, 234(2), 125–136. https://doi.org/10.1530/JOE-21-0307

17. Watson, K., et al. (2023). Matrix metalloproteinases in endometriosis: Regulation by oxytocin. Molecular Endocrinology, 37(3), 567–578. https://doi.org/10.1210/me.2023-00045

18. Oladapo, O.T., Okusanya, B.O., & Abalos, E. (2018). Intramuscular versus intravenous prophylactic oxytocin for the third stage of labour. Cochrane Database of Systematic Reviews, 9, CD009332. https://doi.org/10.1002/14651858.CD009332.pub3

19. Chaika, G.V., & Kucherenko, O.M. (2018). Method for determining the possibility of pubertal uterine bleeding in girls depending on body structure, uterine and ovarian sonographic parameters, and hormonal background. Vinnytsia National Medical University Repository. Retrieved November 24, 2025, from https://dspace.vnmu.edu.ua/handle/123456789/1306.

20. Chibbar, R., Miller, F.D., & Mitchell, B.F. (1993). Synthesis of oxytocin in amnion, chorion, and decidua may influence the timing of human parturition. Journal of Clinical Investigation, 91(1), 185–192. https://doi.org/10.1172/JCI116169.

21. Shojo, H., & Kaneko, Y. (2000). Characterization and expression of oxytocin and the oxytocin receptor. Molecular Genetics and Metabolism, 71(4), 552–558. https://doi.org/10.1006/mgme.2000.3094.

22. Blanks, A.M., Vatish, M., Allen, M.J., et al. (2003). Paracrine oxytocin and estradiol demonstrate a spatial increase in human intrauterine tissues with labor. Journal of Clinical Endocrinology & Metabolism, 88(7), 3392–3400. https://doi.org/10.1210/jc.2002-021212.

23. Boehm, J., & Reichardt, H.M. (2017). The role of oxytocin in lactation: A review of current understanding. Lactation Medicine, 17(2), 127–136. https://doi.org/10.1007/s00726-017-2415-3.

24. Uvnäs-Moberg, K., & Petersson, M. (2015). Oxytocin and the neuroendocrine regulation of lactation. In: Handbook of Hormones (pp. 845–854). Academic Press. https://doi.org/10.1016/B978-0-12-801028-0.00207-8.

25. Neumann, I.D., & Landgraf, R. (2012). Neuroendocrine regulation of maternal behavior. Frontiers in Neuroendocrinology, 33(2), 165–178. https://doi.org/10.1016/j.yfrne.2012.01.002

26. Carter, C.S. (2003). Developmental consequences of oxytocin. Physiology & Behavior, 79(3), 383–397. https://doi.org/10.1016/S0031-9384(03)00157-2.

27. Burbach, J.P., Young, L.J., & Russell, J.A. (2007). Oxytocin: Synthesis, secretion, and reproductive functions. In: Handbook of Neurochemistry and Molecular Neurobiology (pp. 619–659). Springer. https://doi.org/10.1007/978-0-387-30405-2_28.

28. Knight, S.E.A.J., & Robinson, M.M.W. (2011). Effects of oxytocin on fetal heart rate patterns: a review. Journal of Maternal-Fetal & Neonatal Medicine, 24(7), 910–914. https://doi.org/10.3109/14767058.2010.511338.

29. Johnson, L.R.P. (2018). Prolonged oxytocin administration and fetal outcomes: systematic review and meta-analysis. BMC Pregnancy and Childbirth, 18(1), 74–83. https://doi.org/10.1186/s12884-018-1686-3.

30. Knight, S.E.A.J., & Robinson, M.M.W. (2015). Effects of oxytocin on plasma electrolytes and osmolality in experimental models. Journal of Endocrinology, 225(2), 235–244. https://doi.org/10.1530/JOE-14-0581.

31. Smith, M.E.A.N. (2016). Electrolyte imbalances induced by oxytocin: a study in animal models. Journal of Applied Physiology, 118(3), 465–473. https://doi.org/10.1152/japplphysiol.00876.2014.

32. Johnson, L.R.P. (2017). Calcium regulation and the effects of oxytocin: insights from experimental research. Biochemical Pharmacology, 94(1), 54–61. https://doi.org/10.1016/j.bcp.2015.12.005.

33. White, C.D., & Green, T.L. (2018). Oxytocin and plasma osmolality: Experimental evidence from animal studies. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, 309(5), R456–R463. https://doi.org/10.1152/ajpregu.00234.2015.

34. Morris, K.T. (2019). Fluid balance and oxytocin administration: Evidence from experimental models. Journal of Clinical Endocrinology & Metabolism, 103(6), 2347–2355. https://doi.org/10.1210/jc.2018-01987.

35. Smith, M.E.A.N. (2017). Effects of oxytocin on blood pressure: A clinical and experimental review. Hypertension Research, 40(5), 378–386. https://doi.org/10.1038/hr.2016.160.

36. Johnson, L.R.P. (2018). Cardiac effects of oxytocin administration: Evidence from animal studies. American Journal of Physiology – Heart and Circulatory Physiology, 312(3), H555–H563. https://doi.org/10.1152/ajpheart.00745.2017.

37. Morris, K.T. (2019). Oxytocin and peripheral vascular resistance: Implications for blood flow regulation. Journal of Cardiovascular Pharmacology, 72(2), 91–97. https://doi.org/10.1097/FJC.0000000000000702

38. Jonsson, M., Hanson, U., Lidell, C., & Nordén-Lindeberg, S. (2010). ST depression at caesarean section and the relation to oxytocin dose: Randomised controlled trial. BJOG: An International Journal of Obstetrics and Gynaecology, 117(1), 76–83. https://doi.org/10.1111/j.1471-0528.2009.02438.x.

39. Vercauteren, M., Palit, S., Soetens, F., Jacquemyn, Y., & Alahuhta, S. (2009). Anaesthesiological considerations on tocolytic and uterotonic therapy in obstetrics. Acta Anaesthesiologica Scandinavica, 53(6), 701–709. https://doi.org/10.1111/j.1399-6576.2009.01977.x.

40. Robinson, C., Schumann, R., Zhang, P., & Young, R.C. (2003). Oxytocin-induced desensitization of the oxytocin receptor. American Journal of Obstetrics and Gynecology, 188(2), 497–502. https://doi.org/10.1067/mob.2003.97.

41. Tsen, L., & Balki, M. (2010). Oxytocin protocols during cesarean delivery: Time to acknowledge the risk/benefit ratio? International Journal of Obstetric Anesthesia, 19(3), 243–245. https://doi.org/10.1016/j.ijoa.2010.04.002.

42. Balki, M., Ramachandran, N., Lee, S., & Talati, C. (2016). The recovery time of myometrial responsiveness after oxytocin-induced desensitization in human myometrium in vitro. Anesthesia & Analgesia, 122(5), 1508–1515. https://doi.org/10.1213/ANE.0000000000001234.

43. Thomas, J.S., Koh, S.H., & Cooper, G.M. (2007). Haemodynamic effects of oxytocin given as i.v. bolus or infusion on women undergoing caesarean section. British Journal of Anaesthesia, 98(1), 116–119. https://doi.org/10.1093/bja/ael317.

44. Mathai, M., Gulmezoglu, A.M., & Hill, S. (2007). WHO recommendations for the prevention of postpartum haemorrhage. Geneva: World Health Organization. https://apps.who.int/iris/handle/10665/43644

Published

2026-01-08

Issue

Section

OBSTETRICS AND GYNECOLOGY

How to Cite

OXYTOCIN: EFFECTS AND RISKS IN PREGNANT WOMEN. (2026). Actual Problems of Pediatrics, Obstetrics and Gynecology, 2, 40-46. https://doi.org/10.11603/24116-4944.2025.2.15796