FEATURES OF PRO-INFLAMMATORY CYTOKINES (IL-6 AND TNF-α) IN CHILDREN WITH COVID-19
DOI:
https://doi.org/10.11603/24116-4944.2024.1.14755Keywords:
COVID-19, children, interleukin-6, tumor necrosis factor-alfaAbstract
The aim of the study – to evaluate IL-6 and TNF-a levels in children with COVID-19 and their dependence on the severity of the disease
Materials and Methods. 112 children with COVID-19, aged 1 month to 18 years, who were hospitalized at the Department of Infectious Diseases of Ternopil City Children's Hospital were examined. The level of IL-6 and TNF-a in serum samples was determined by enzyme-linked immunosorbent assay using standard kits (BT Lab, China).
Results and Discussion. The average age of children was (7.04±5.75) years (95% CI 5.96−8.12). Regarding disease severity, 57 children (42.23%) had a mild course of the disease, 43 children (31.86%) had a moderate course, and 12 children (8.88%) had a severe course. The concentration of IL-6 in children with a mild course of COVID-19 was 80.36 ng/ml; with a moderate course – 101 ng/ml; with a severe course – 151.90 ng/ml (р<0.001). The level of TNF-a in mild COVID-19 was 56.7 ng/ml; 97.73 ng/ml – in moderate disease severity, and 182.42 ng/ml – in severe cases (р<0.001).
Conclusions. The level of cytokines IL-6 and TNF-a in children with COVID-19 depends on the severity of the disease. Patients with severe COVID-19 have significantly higher levels of IL-6 and TNF-α compared to mild and moderate COVID-19. Correlative relationships between high levels of IL-6, TNF-α and C-reactive protein, ESR, and lymphocytes were found in children with COVID-19. No gender patterns were found in relation to cytokines (IL-6, TNF-α) and age-specific characteristics in relation to TNF-α indicators.
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