STRUCTURAL REACTION OF PULMONARY TISSUE AND BLOOD VESSELS OF SMALL CIRCLE OF BLOOD CIRCULATION IN THE TERMINAL STAGE OF ACUTE PERITONITIS
DOI:
https://doi.org/10.11603/1811-2471.2018.v0.i3.9391Keywords:
peritonitis, terminal stage, pulmonary parenchyma, blood vessels of small circle of blood circulation, alveoli, interalveolar septa, endotheliumAbstract
The aim of our investigation was an experimental study of changes in the structure of pulmonary tissue and vessels of the pulmonary circulation at the terminal stage of acute peritonitis.
Materials and Methods. Morphometric (measurement of thickness of interalveolar septa and diameter of alveoli) histological for the studying the structure of lung tissue and vessels with light-optical microscopy, statistical. The experiments were performed on 40 white male rats: 10 animals made up an intact control group; acute peritonitis (terminal stage) was modeled in 30 animals.
Results and Discussion. The character and dynamics of structural changes development, the range of compensatory and adaptive reactions are the fundamental component of the searching for correction of the negative impact of pathological factors to the body. The study of peritonitis remains an urgent problem of modern clinical medicine. Since peritonitis leads to severe organ pathology, the development of multiple organ failure and death. Further narrowing of the lumen of the alveoli and accumulation of the transudate in the pulmonary interstitium were found after 36 hours from the start of the experiment. In the terminal phase, a paralyzed expansion of the arterial lumen and a collapsed state of the veins were observed. The character of the morpho-functional changes in the lung tissue and vessels of the small circulation, established in the process of experiment, their dynamics and depth testify to the pronounced effect of toxic metabolic products in the development of endotoxicosis.
Conclusions. Experimental acute peritonitis in white male rats at the terminal stage caused a significant narrowing of the diameter of the alveoli and the lumen of bronchioles against the background of a significant thickening of the interalveolar septa. Endotoxicosis in the conditions of this pathology caused the development of dystrophic processes and disruption of normal tissue-vascular relationships in the lung tissue.
References
Banul, B.Yu., & Makar, B.H. (2014). Funktsionalni ta strukturni zminy v orhanakh dykhalnoi systemy pid vplyvom riznykh chynnykiv [Functional and structural changes in the organs of the respiratory system under the influence of various factors]. Klinichna anatomiia ta operatyvna khirurhiia – Clinical Anatomy and Operative Surgery, 13 (2), 94-98 [in Ukrainian].
Hantimurov, I.E., Herasymiuk, V.A., Chepesiuk, L.A. & Herasymiuk, L.O. (2009). Osoblyvosti morfo-funktsionalnykh reaktsii sudyn pechinky ta nyrok v dynamitsi rozvytku hostroho rozlytoho perytonitu [Features of morpho-functional reactions of blood vessels of the liver and kidneys in the dynamics of development of acute diffuse peritonitis]. Zdobutky klinichnoi ta eksperymentalnoi medytsyny – Achievements of Clinical and Experimental Medicine, 2, 119 [in Ukrainian].
Kononenko, M.H., Danylenko, I.A., Kashchenko, L.H., Antonenko, O.N., Oliseienko, D.V. & Deineka, V.M. (2014). Perytonit: intestynalna intubatsiia [Peritonitis: intestinal intubation]. Kharkivska khirurhichna shkola – Kharkiv Surgical School, 3 (66), 63-66 [in Ukrainian].
Kryvoruchko, I.A., Boiko, V.V. & Sivozhelizov, A.V. (2012). Rozpovsiudzhenyi hniinyi perytonit [Diffuse purulent peritonitis]. Halytskyi likarskyi visnyk – Halytskyi Doctor Journal, 19, 3 (part 2), 71-73 [in Ukrainian].
Kryshen, V.P., Liashchenko, P.V., Chornyi, V.I., Bondarenko, Yu.M., Hrabchuk, V.M., & Didenko, V.I. (2013). Dynamika pokaznykiv poliorhannoi nedostatnosti u khvorykh z rozpovsiudzhenym perytonitom pry zastosuvanni transmembrannoho dializu [Dynamics of multiorgan failure in patients with diffuse peritonitis in the use of transmembrane dialysis]. Kharkivska khirurhichna shkola – Kharkiv Surgical School, 1 (58), 50-52 [in Ukrainian].
Polianskyi, I.Yu., Hrynchuk, V.F., Andriiets, V.V., Moskaliuk, V.I. & Moroz, V.A. (2011). Alhorytmy likuvalnoi taktyky pry hostromu perytoniti [Algorithms of medical tactics for acute peritonitis]. Suchasni medychni tekhnolohii – Modern Medical Technologies, 3-4, 310-312 [in Ukrainian].
Polianskyi, I.Yu., Hrynchuk, F.V., Andriiets, V.V., Maksymiuk, V.V., Brodovskyi, S.P. & Voitiv, Ya.Yu. (2012). Klasyfikatsiia hostroho perytonitu [Classification of acute peritonitis]. Klinichna anatomiia ta operatyvna khirurhiia – Clinical Anatomy and Surgical Surgery, 11 (2), 78-80 [in Ukrainian].
Pronina, O.M., Koptev, M.M., Danylchenko, S.I. & Polovyk, O.Yu. (2011). Premorbidni zminy lehenevoi tkanyny vnaslidok hostroi stresovoi reaktsii v eksperymenti [Premorbid changes in pulmonary tissue due to acute stress reaction in the experiment]. Visnyk problem biolohii i medytsyny – Bulletin of the Problems of Biology and Medicine, 2 (88), 154-156 [in Ukrainian].
Hvorostov, Ye.D., Zakharchenko, Yu.B., Tomin, M.S. & Morozov, S.O. (2011). Kompleksna diahnostyka hostroho hniinoho perytonitu u khvorykh z atypovoiu klinichnoiu kartynoiu [Complex diagnostics of acute purulent peritonitis in patients with atypical clinical manifistation]. Naukovyi visnyk Uzhhorodskoho universytetu, seriia “Medytsyna” – Scientific Herald of Uzhhorod University, series "Medicine", 41, 265-267 [in Ukrainian].
Strukov, A.I., Petrova, V.I. & Paukova, V.S. (Ed.). (1987). Ostryy razlitoy peritonit [Acute diffuse peritonitis]. Moscow: Meditsina [in Russian].
